ENSG00000130511

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000270061 ENSG00000130511 HEK293_OSMI2_2hA HEK293_TMG_2hB SSBP4 protein_coding protein_coding 52.70537 92.43245 28.0338 8.995494 3.596881 -1.720874 5.051705 3.266513 3.983615 3.266513 0.04153399 0.2855341 0.10741250 0.03840000 0.14633333 0.107933333 9.347529e-02 5.156603e-08 FALSE TRUE
ENST00000601444 ENSG00000130511 HEK293_OSMI2_2hA HEK293_TMG_2hB SSBP4 protein_coding retained_intron 52.70537 92.43245 28.0338 8.995494 3.596881 -1.720874 7.835487 9.605246 4.430158 4.957676 2.30036165 -1.1147128 0.16590000 0.09993333 0.14483333 0.044900000 9.711640e-01 5.156603e-08 FALSE FALSE
ENST00000602088 ENSG00000130511 HEK293_OSMI2_2hA HEK293_TMG_2hB SSBP4 protein_coding protein_coding 52.70537 92.43245 28.0338 8.995494 3.596881 -1.720874 3.210770 5.368050 1.582090 2.937825 1.58209009 -1.7561613 0.06108333 0.05400000 0.04516667 -0.008833333 6.053485e-01 5.156603e-08 FALSE TRUE
MSTRG.16733.15 ENSG00000130511 HEK293_OSMI2_2hA HEK293_TMG_2hB SSBP4 protein_coding   52.70537 92.43245 28.0338 8.995494 3.596881 -1.720874 15.010267 39.038309 5.426201 2.927683 1.51184791 -2.8445894 0.24730417 0.42673333 0.20293333 -0.223800000 9.098745e-02 5.156603e-08 FALSE TRUE
MSTRG.16733.3 ENSG00000130511 HEK293_OSMI2_2hA HEK293_TMG_2hB SSBP4 protein_coding   52.70537 92.43245 28.0338 8.995494 3.596881 -1.720874 9.783499 7.895554 8.850879 5.762520 1.25369201 0.1645833 0.20660417 0.09110000 0.33336667 0.242266667 7.606430e-02 5.156603e-08 FALSE TRUE
MSTRG.16733.5 ENSG00000130511 HEK293_OSMI2_2hA HEK293_TMG_2hB SSBP4 protein_coding   52.70537 92.43245 28.0338 8.995494 3.596881 -1.720874 2.341593 10.406888 0.000000 4.044081 0.00000000 -10.0247086 0.02968750 0.10903333 0.00000000 -0.109033333 5.156603e-08 5.156603e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130511 E001 0.1451727 0.0427938877 1.209266e-01   19 18418864 18419149 286 + 0.212 0.000 -11.264
ENSG00000130511 E002 1.6866953 0.0174277308 4.233187e-01 5.663760e-01 19 18419336 18419343 8 + 0.212 0.371 1.100
ENSG00000130511 E003 5.5177411 0.0031185274 8.810273e-01 9.277370e-01 19 18419344 18419394 51 + 0.733 0.702 -0.126
ENSG00000130511 E004 6.8139738 0.0024957989 5.372005e-01 6.688158e-01 19 18419395 18419397 3 + 0.863 0.769 -0.369
ENSG00000130511 E005 7.6965495 0.0022570646 6.919892e-02 1.420425e-01 19 18419398 18419404 7 + 1.019 0.781 -0.905
ENSG00000130511 E006 12.2316915 0.0014589825 7.141494e-05 3.870615e-04 19 18419405 18419413 9 + 1.312 0.907 -1.467
ENSG00000130511 E007 15.4488454 0.0013131245 2.007036e-09 2.808383e-08 19 18419414 18419425 12 + 1.486 0.950 -1.905
ENSG00000130511 E008 15.4488731 0.0046708819 1.203424e-09 1.755758e-08 19 18419426 18419429 4 + 1.503 0.941 -1.997
ENSG00000130511 E009 99.9498626 0.0226696839 8.846277e-05 4.677889e-04 19 18419430 18419605 176 + 2.129 1.812 -1.067
ENSG00000130511 E010 73.0455285 0.0150037928 9.016673e-03 2.631980e-02 19 18419606 18419615 10 + 1.905 1.711 -0.655
ENSG00000130511 E011 73.1350441 0.0120023696 4.517347e-03 1.459310e-02 19 18419616 18419623 8 + 1.912 1.710 -0.680
ENSG00000130511 E012 95.5861706 0.0205303621 2.516156e-03 8.812198e-03 19 18419624 18419648 25 + 2.054 1.817 -0.796
ENSG00000130511 E013 167.6086171 0.0049173708 1.255502e-03 4.828090e-03 19 18419649 18419707 59 + 2.232 2.079 -0.511
ENSG00000130511 E014 1.1230491 0.1982633913 2.392331e-02 5.964468e-02 19 18420063 18420069 7 + 0.620 0.126 -3.231
ENSG00000130511 E015 3.7748231 0.0049252668 1.468534e-03 5.535072e-03 19 18420070 18420102 33 + 0.932 0.455 -2.031
ENSG00000130511 E016 4.0714095 0.0106332845 4.512333e-03 1.457790e-02 19 18420103 18420124 22 + 0.932 0.503 -1.792
ENSG00000130511 E017 5.1572451 0.0971568529 1.661725e-02 4.409534e-02 19 18425909 18426039 131 + 1.044 0.565 -1.916
ENSG00000130511 E018 2.7613611 0.1308394853 2.642214e-03 9.197403e-03 19 18426040 18426083 44 + 0.932 0.300 -2.926
ENSG00000130511 E019 274.1831286 0.0007361785 1.008788e-02 2.897742e-02 19 18427351 18427423 73 + 2.385 2.305 -0.270
ENSG00000130511 E020 285.7862424 0.0001835912 6.675934e-02 1.380053e-01 19 18427752 18427813 62 + 2.384 2.328 -0.189
ENSG00000130511 E021 362.4645983 0.0001860640 3.811239e-01 5.254244e-01 19 18427898 18427982 85 + 2.432 2.444 0.038
ENSG00000130511 E022 373.0604971 0.0089767059 1.325259e-01 2.375879e-01 19 18430841 18430930 90 + 2.403 2.470 0.223
ENSG00000130511 E023 63.4455792 0.0004657599 3.477086e-02 8.120659e-02 19 18431353 18431418 66 + 1.596 1.710 0.389
ENSG00000130511 E024 1.4037409 0.0116073082 1.285828e-01 2.321811e-01 19 18431645 18431646 2 + 0.547 0.265 -1.586
ENSG00000130511 E025 260.4567916 0.0002767805 1.434563e-01 2.527139e-01 19 18431647 18431671 25 + 2.273 2.305 0.109
ENSG00000130511 E026 291.1548928 0.0002170709 1.120715e-02 3.166394e-02 19 18431672 18431706 35 + 2.297 2.357 0.199
ENSG00000130511 E027 4.8481200 0.0041376885 9.975861e-01 1.000000e+00 19 18431707 18431792 86 + 0.679 0.672 -0.031
ENSG00000130511 E028 290.0244467 0.0001568427 2.925765e-02 7.050185e-02 19 18431793 18431812 20 + 2.304 2.353 0.164
ENSG00000130511 E029 382.1723451 0.0001462024 1.981654e-02 5.109680e-02 19 18431813 18431862 50 + 2.426 2.471 0.150
ENSG00000130511 E030 389.9388654 0.0002765460 3.728194e-01 5.172390e-01 19 18432000 18432066 67 + 2.463 2.475 0.040
ENSG00000130511 E031 237.8555319 0.0002404627 4.078453e-01 5.514364e-01 19 18432067 18432070 4 + 2.246 2.261 0.051
ENSG00000130511 E032 389.5129442 0.0008862674 1.294856e-01 2.334408e-01 19 18432147 18432199 53 + 2.447 2.480 0.109
ENSG00000130511 E033 310.0117248 0.0043524630 1.828117e-01 3.047268e-01 19 18432200 18432214 15 + 2.338 2.386 0.163
ENSG00000130511 E034 387.1147161 0.0039725237 4.547880e-01 5.953813e-01 19 18432559 18432604 46 + 2.456 2.478 0.076
ENSG00000130511 E035 7.1846703 0.0024258104 4.693578e-01 6.085979e-01 19 18432605 18432699 95 + 0.899 0.793 -0.411
ENSG00000130511 E036 355.6626874 0.0028126028 8.152240e-01 8.829733e-01 19 18432700 18432735 36 + 2.435 2.438 0.009
ENSG00000130511 E037 410.1785572 0.0009113717 3.952229e-01 5.390443e-01 19 18432829 18432883 55 + 2.486 2.501 0.048
ENSG00000130511 E038 411.8710009 0.0005598091 3.662911e-02 8.476486e-02 19 18432973 18433043 71 + 2.463 2.506 0.144
ENSG00000130511 E039 4.1738226 0.0037959322 1.356732e-05 8.740987e-05 19 18433044 18433100 57 + 1.044 0.428 -2.584
ENSG00000130511 E040 318.9496573 0.0004197436 1.345766e-02 3.698324e-02 19 18433135 18433213 79 + 2.337 2.395 0.194
ENSG00000130511 E041 39.5230120 0.0607849257 3.138828e-01 4.565246e-01 19 18433275 18433584 310 + 1.625 1.461 -0.559
ENSG00000130511 E042 240.9081535 0.0005067709 8.613618e-01 9.145715e-01 19 18433585 18433613 29 + 2.274 2.261 -0.046
ENSG00000130511 E043 2.7283507 0.2427298515 1.837065e-02 4.794347e-02 19 18433614 18433652 39 + 0.863 0.314 -2.565
ENSG00000130511 E044 331.6271006 0.0036449146 4.499539e-01 5.911420e-01 19 18433710 18433817 108 + 2.388 2.411 0.076
ENSG00000130511 E045 107.7964909 0.0228226896 4.628934e-02 1.025598e-01 19 18433818 18433932 115 + 2.052 1.888 -0.550
ENSG00000130511 E046 443.0894945 0.0006290308 1.566615e-02 4.199311e-02 19 18434217 18434562 346 + 2.490 2.540 0.167