ENSG00000130413

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358872 ENSG00000130413 HEK293_OSMI2_2hA HEK293_TMG_2hB STK33 protein_coding protein_coding 4.232374 4.78316 5.792362 0.1066811 0.3307099 0.2756632 0.1779059 0.70155221 0.3192401 0.43050963 0.3192401 -1.1118296 0.03878333 0.15000000 0.04980000 -0.10020000 0.57498075 0.01339476 FALSE TRUE
ENST00000473980 ENSG00000130413 HEK293_OSMI2_2hA HEK293_TMG_2hB STK33 protein_coding processed_transcript 4.232374 4.78316 5.792362 0.1066811 0.3307099 0.2756632 0.3942037 0.42847287 0.3599518 0.42847287 0.2116970 -0.2451504 0.09451250 0.08576667 0.05843333 -0.02733333 0.75887494 0.01339476 FALSE TRUE
ENST00000534493 ENSG00000130413 HEK293_OSMI2_2hA HEK293_TMG_2hB STK33 protein_coding protein_coding 4.232374 4.78316 5.792362 0.1066811 0.3307099 0.2756632 0.1428000 0.10291278 0.7811623 0.10291278 0.4271708 2.8087648 0.02670000 0.02200000 0.14133333 0.11933333 0.53063710 0.01339476 FALSE TRUE
ENST00000687296 ENSG00000130413 HEK293_OSMI2_2hA HEK293_TMG_2hB STK33 protein_coding protein_coding 4.232374 4.78316 5.792362 0.1066811 0.3307099 0.2756632 0.5394472 0.14698356 0.9669677 0.07484444 0.1772877 2.6376973 0.12529583 0.03030000 0.17146667 0.14116667 0.04017061 0.01339476 FALSE TRUE
MSTRG.5105.12 ENSG00000130413 HEK293_OSMI2_2hA HEK293_TMG_2hB STK33 protein_coding   4.232374 4.78316 5.792362 0.1066811 0.3307099 0.2756632 0.9805170 0.64979861 0.8432067 0.10646283 0.4226409 0.3708695 0.23886250 0.13696667 0.14616667 0.00920000 0.91937768 0.01339476 FALSE TRUE
MSTRG.5105.22 ENSG00000130413 HEK293_OSMI2_2hA HEK293_TMG_2hB STK33 protein_coding   4.232374 4.78316 5.792362 0.1066811 0.3307099 0.2756632 0.7159667 2.16757598 0.6677373 0.09154883 0.3338859 -1.6839251 0.16292083 0.45333333 0.11520000 -0.33813333 0.21345256 0.01339476   FALSE
MSTRG.5105.3 ENSG00000130413 HEK293_OSMI2_2hA HEK293_TMG_2hB STK33 protein_coding   4.232374 4.78316 5.792362 0.1066811 0.3307099 0.2756632 0.2716475 0.08217365 0.3578044 0.08217365 0.3031538 1.9965126 0.07025833 0.01643333 0.06220000 0.04576667 0.78663946 0.01339476 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130413 E001 0.0000000       11 8391868 8391869 2 -      
ENSG00000130413 E002 0.1472490 0.0429709483 8.543958e-01   11 8391870 8391870 1 - 0.093 0.000 -9.733
ENSG00000130413 E003 0.1472490 0.0429709483 8.543958e-01   11 8391871 8391878 8 - 0.093 0.000 -9.731
ENSG00000130413 E004 16.0178849 0.0117711317 1.127526e-02 3.181935e-02 11 8391879 8392186 308 - 1.112 1.362 0.884
ENSG00000130413 E005 22.8709748 0.0143435487 7.454382e-03 2.239684e-02 11 8392187 8392369 183 - 1.260 1.503 0.846
ENSG00000130413 E006 46.3241046 0.0102060182 4.032385e-03 1.323248e-02 11 8392370 8392710 341 - 1.579 1.776 0.668
ENSG00000130413 E007 40.2575653 0.0009218119 1.660500e-01 2.830685e-01 11 8413495 8413692 198 - 1.569 1.652 0.285
ENSG00000130413 E008 3.1441037 0.0049317516 3.082969e-02 7.358504e-02 11 8433860 8434243 384 - 0.724 0.367 -1.693
ENSG00000130413 E009 21.6174836 0.0271919209 8.646632e-01 9.167615e-01 11 8435494 8435579 86 - 1.352 1.337 -0.052
ENSG00000130413 E010 20.2828848 0.0479840992 8.547467e-01 9.101492e-01 11 8436027 8436139 113 - 1.293 1.335 0.146
ENSG00000130413 E011 14.9023425 0.0105112593 6.428074e-01 7.555213e-01 11 8440678 8440725 48 - 1.165 1.219 0.193
ENSG00000130413 E012 13.3854974 0.0019492377 6.260074e-01 7.420225e-01 11 8440726 8440753 28 - 1.165 1.128 -0.133
ENSG00000130413 E013 20.6766691 0.0010897808 2.101496e-01 3.387120e-01 11 8452822 8452906 85 - 1.361 1.273 -0.308
ENSG00000130413 E014 12.7771096 0.0023927315 2.746949e-01 4.138873e-01 11 8454744 8454759 16 - 1.165 1.066 -0.354
ENSG00000130413 E015 17.7789788 0.0038260545 2.762259e-01 4.156552e-01 11 8454760 8454832 73 - 1.293 1.207 -0.302
ENSG00000130413 E016 28.2774055 0.0012963430 5.922432e-01 7.148264e-01 11 8457341 8457479 139 - 1.461 1.434 -0.093
ENSG00000130413 E017 19.0066624 0.0013243527 8.710239e-01 9.210723e-01 11 8461805 8461848 44 - 1.288 1.283 -0.015
ENSG00000130413 E018 20.0009850 0.0011738674 8.554476e-01 9.106044e-01 11 8461849 8461909 61 - 1.308 1.303 -0.019
ENSG00000130413 E019 25.9243461 0.0008038938 7.014113e-02 1.436031e-01 11 8464709 8464822 114 - 1.458 1.340 -0.409
ENSG00000130413 E020 3.8803342 0.0128072656 3.641271e-02 8.436616e-02 11 8464823 8467654 2832 - 0.779 0.443 -1.497
ENSG00000130413 E021 18.1600775 0.0186644164 6.021916e-01 7.232048e-01 11 8473163 8473276 114 - 1.287 1.243 -0.155
ENSG00000130413 E022 0.0000000       11 8474648 8474680 33 -      
ENSG00000130413 E023 10.1304629 0.0123236616 5.844510e-01 7.083792e-01 11 8474681 8474714 34 - 1.052 0.996 -0.204
ENSG00000130413 E024 11.7683501 0.0014360343 4.287045e-01 5.714260e-01 11 8474715 8474792 78 - 1.120 1.049 -0.255
ENSG00000130413 E025 7.8725793 0.0021785505 1.546090e-01 2.678845e-01 11 8474793 8474816 24 - 0.993 0.830 -0.615
ENSG00000130413 E026 5.7826166 0.0450978168 6.571165e-02 1.362245e-01 11 8474817 8474818 2 - 0.912 0.615 -1.201
ENSG00000130413 E027 17.6102899 0.0013784520 1.758804e-02 4.624182e-02 11 8474819 8475066 248 - 1.323 1.128 -0.691
ENSG00000130413 E028 4.2406239 0.0038348808 1.262299e-02 3.502068e-02 11 8475067 8475824 758 - 0.828 0.443 -1.692
ENSG00000130413 E029 3.3559839 0.0046246797 2.011642e-01 3.276415e-01 11 8476687 8476751 65 - 0.704 0.507 -0.873
ENSG00000130413 E030 2.9264429 0.1606689020 5.659153e-01 6.929488e-01 11 8477250 8477283 34 - 0.636 0.507 -0.588
ENSG00000130413 E031 2.1402015 0.0069711627 2.586430e-01 3.959494e-01 11 8480410 8480482 73 - 0.560 0.367 -0.982
ENSG00000130413 E032 2.6207590 0.0057583390 2.744337e-02 6.689137e-02 11 8480483 8480533 51 - 0.661 0.276 -2.013
ENSG00000130413 E033 4.4745027 0.1046581445 1.191600e-01 2.187410e-01 11 8480534 8480614 81 - 0.827 0.511 -1.349
ENSG00000130413 E034 0.0000000       11 8533348 8533496 149 -      
ENSG00000130413 E035 0.0000000       11 8565710 8565911 202 -      
ENSG00000130413 E036 0.0000000       11 8567251 8567293 43 -      
ENSG00000130413 E037 5.5690361 0.0030903574 6.341821e-06 4.411379e-05 11 8572674 8572719 46 - 0.464 1.066 2.479
ENSG00000130413 E038 0.2903454 0.2558864486 4.944855e-01   11 8580814 8580960 147 - 0.169 0.000 -10.727
ENSG00000130413 E039 4.7084127 0.0035775560 1.186076e-01 2.179529e-01 11 8593744 8594082 339 - 0.638 0.858 0.895
ENSG00000130413 E040 13.8851486 0.0013563755 2.748981e-01 4.141276e-01 11 8594083 8594289 207 - 1.112 1.218 0.380