ENSG00000130396

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000400825 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding protein_coding 29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 0.6292269 0.0000000 4.0106794 0.0000000 1.19620233 8.651295 0.01685833 0.00000000 0.102700000 0.10270000 2.448409e-12 7.47652e-32 FALSE FALSE
ENST00000485634 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding protein_coding 29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 1.0952252 2.1410341 0.0000000 0.2724055 0.00000000 -7.748887 0.04424167 0.09826667 0.000000000 -0.09826667 7.476520e-32 7.47652e-32 FALSE TRUE
ENST00000486649 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding processed_transcript 29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 1.0078903 1.9167864 0.0000000 1.2974337 0.00000000 -7.590053 0.04174583 0.08880000 0.000000000 -0.08880000 1.185892e-01 7.47652e-32   FALSE
ENST00000507704 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding protein_coding 29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 0.4947702 1.1422408 0.0000000 0.6390809 0.00000000 -6.848298 0.02060417 0.05103333 0.000000000 -0.05103333 1.012597e-01 7.47652e-32 FALSE TRUE
ENST00000511503 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding retained_intron 29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 4.1876853 1.6015187 3.9901554 0.2000422 0.08897544 1.311635 0.13956667 0.07433333 0.103166667 0.02883333 2.283977e-01 7.47652e-32   FALSE
MSTRG.29321.1 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding   29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 0.8717997 0.0000000 2.4259493 0.0000000 0.32040143 7.928340 0.02575417 0.00000000 0.062766667 0.06276667 3.719722e-16 7.47652e-32 FALSE TRUE
MSTRG.29321.13 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding   29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 2.5887409 1.3061098 0.5532779 0.3018537 0.55327786 -1.224361 0.08513750 0.06066667 0.014366667 -0.04630000 1.327045e-01 7.47652e-32 FALSE TRUE
MSTRG.29321.14 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding   29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 1.5465094 0.0000000 2.3090197 0.0000000 0.25296629 7.857371 0.04452083 0.00000000 0.059733333 0.05973333 3.625376e-18 7.47652e-32 FALSE TRUE
MSTRG.29321.16 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding   29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 2.7235397 0.6528554 5.0866522 0.3275156 0.46814589 2.942784 0.08245000 0.03093333 0.131900000 0.10096667 2.383256e-01 7.47652e-32 FALSE TRUE
MSTRG.29321.19 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding   29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 2.8289402 1.9543306 6.9887917 0.1587225 1.23867831 1.833068 0.09427500 0.09080000 0.180433333 0.08963333 7.918655e-02 7.47652e-32 FALSE TRUE
MSTRG.29321.24 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding   29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 1.8466241 0.6763268 3.5398470 0.3390165 1.77631977 2.370789 0.05677083 0.03033333 0.091266667 0.06093333 8.670849e-01 7.47652e-32 FALSE TRUE
MSTRG.29321.37 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding   29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 1.0624892 4.2060497 0.2894505 1.5531356 0.28945046 -3.815503 0.04788333 0.19693333 0.007500000 -0.18943333 2.475021e-02 7.47652e-32 FALSE TRUE
MSTRG.29321.38 ENSG00000130396 HEK293_OSMI2_2hA HEK293_TMG_2hB AFDN protein_coding   29.83095 21.66092 38.68525 0.6621264 0.7699551 0.8363964 1.2036181 2.9748311 0.1214784 1.7652793 0.12147841 -4.504751 0.04718333 0.13456667 0.003166667 -0.13140000 1.611168e-02 7.47652e-32 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130396 E001 1.7820913 0.0080251636 8.651642e-03 2.541207e-02 6 167826878 167826910 33 + 0.511 0.000 -16.911
ENSG00000130396 E002 2.0787794 0.0071452086 4.137288e-03 1.352750e-02 6 167826911 167826921 11 + 0.558 0.000 -17.121
ENSG00000130396 E003 3.8826406 0.0040670364 1.054037e-03 4.146524e-03 6 167826922 167826933 12 + 0.753 0.195 -3.039
ENSG00000130396 E004 6.3969381 0.0025826186 4.538807e-06 3.262743e-05 6 167826934 167826960 27 + 0.946 0.195 -3.788
ENSG00000130396 E005 9.4937752 0.0017296868 4.929938e-09 6.442450e-08 6 167826961 167826990 30 + 1.106 0.195 -4.373
ENSG00000130396 E006 8.8941700 0.0018180887 1.811357e-08 2.128488e-07 6 167826991 167826999 9 + 1.080 0.195 -4.278
ENSG00000130396 E007 19.2153740 0.0009441789 1.990902e-10 3.336611e-09 6 167827000 167827095 96 + 1.369 0.744 -2.302
ENSG00000130396 E008 20.2826713 0.0009379904 3.735898e-07 3.388818e-06 6 167827096 167827132 37 + 1.369 0.952 -1.495
ENSG00000130396 E009 54.2766990 0.0007761663 5.925229e-11 1.085186e-09 6 167827133 167827237 105 + 1.767 1.460 -1.047
ENSG00000130396 E010 1.3641904 0.0122052368 2.077077e-01 3.357200e-01 6 167827635 167827932 298 + 0.397 0.195 -1.395
ENSG00000130396 E011 117.4468162 0.0052156864 6.030769e-11 1.102172e-09 6 167864551 167864746 196 + 2.090 1.825 -0.888
ENSG00000130396 E012 28.3173140 0.0046006417 2.443426e-06 1.865252e-05 6 167870383 167870385 3 + 1.495 1.165 -1.149
ENSG00000130396 E013 115.3521404 0.0161072703 5.931622e-07 5.172273e-06 6 167870386 167870498 113 + 2.085 1.800 -0.957
ENSG00000130396 E014 37.3132753 0.0288415217 2.164818e-04 1.034685e-03 6 167872214 167872216 3 + 1.608 1.286 -1.110
ENSG00000130396 E015 136.8820210 0.0127209294 8.620146e-06 5.813260e-05 6 167872217 167872377 161 + 2.143 1.941 -0.678
ENSG00000130396 E016 136.2552168 0.0028219025 1.742537e-10 2.950647e-09 6 167875335 167875495 161 + 2.140 1.944 -0.657
ENSG00000130396 E017 88.1725189 0.0003266694 2.133362e-13 5.786100e-12 6 167880360 167880434 75 + 1.962 1.712 -0.844
ENSG00000130396 E018 69.1385829 0.0003841073 2.919190e-11 5.633983e-10 6 167880435 167880480 46 + 1.861 1.604 -0.872
ENSG00000130396 E019 75.0367272 0.0003586003 1.137481e-08 1.387856e-07 6 167880481 167880517 37 + 1.882 1.692 -0.640
ENSG00000130396 E020 108.8669107 0.0002701810 8.589075e-15 2.854692e-13 6 167889215 167889326 112 + 2.049 1.818 -0.779
ENSG00000130396 E021 141.5276561 0.0002850746 6.137216e-22 4.852576e-20 6 167890862 167891029 168 + 2.170 1.902 -0.897
ENSG00000130396 E022 0.0000000       6 167893680 167893861 182 +      
ENSG00000130396 E023 0.2966881 0.0271722780 5.855453e-01   6 167893862 167893906 45 + 0.138 0.000 -14.313
ENSG00000130396 E024 96.8654644 0.0008569952 1.012181e-08 1.246374e-07 6 167896878 167896972 95 + 1.986 1.821 -0.556
ENSG00000130396 E025 191.7365763 0.0013022348 2.257568e-10 3.745092e-09 6 167898205 167898467 263 + 2.273 2.143 -0.432
ENSG00000130396 E026 114.2508850 0.0002711192 9.082900e-13 2.246088e-11 6 167902317 167902386 70 + 2.065 1.870 -0.654
ENSG00000130396 E027 135.3843979 0.0002558337 1.426756e-14 4.598262e-13 6 167907171 167907289 119 + 2.138 1.946 -0.643
ENSG00000130396 E028 75.1555784 0.0010880550 3.360243e-04 1.524542e-03 6 167911101 167911162 62 + 1.863 1.778 -0.289
ENSG00000130396 E029 129.4696243 0.0002359971 2.527091e-06 1.923076e-05 6 167911284 167911489 206 + 2.093 2.013 -0.266
ENSG00000130396 E030 12.3220277 0.0169272467 1.483803e-02 4.012477e-02 6 167911490 167912164 675 + 1.130 0.896 -0.865
ENSG00000130396 E031 16.5611154 0.0010639725 1.045749e-01 1.974761e-01 6 167913403 167913423 21 + 1.217 1.148 -0.247
ENSG00000130396 E032 11.8962305 0.0014200429 2.972755e-04 1.368668e-03 6 167913541 167914167 627 + 1.142 0.786 -1.334
ENSG00000130396 E033 53.7102176 0.0047176223 4.687928e-03 1.506350e-02 6 167914168 167914173 6 + 1.717 1.622 -0.322
ENSG00000130396 E034 122.4479223 0.0002812686 1.285151e-04 6.524142e-04 6 167914174 167914313 140 + 2.060 2.009 -0.172
ENSG00000130396 E035 103.0913241 0.0002957316 5.939800e-06 4.158607e-05 6 167914644 167914738 95 + 1.999 1.905 -0.313
ENSG00000130396 E036 155.8898176 0.0023904570 1.696598e-05 1.069414e-04 6 167915168 167915400 233 + 2.173 2.089 -0.282
ENSG00000130396 E037 78.2052177 0.0128065338 2.127531e-01 3.417801e-01 6 167915401 167915433 33 + 1.851 1.855 0.014
ENSG00000130396 E038 136.6604761 0.0035567698 1.694413e-02 4.480695e-02 6 167917089 167917232 144 + 2.098 2.080 -0.060
ENSG00000130396 E039 171.7405562 0.0002744027 5.714151e-02 1.217104e-01 6 167918735 167918933 199 + 2.181 2.212 0.102
ENSG00000130396 E040 134.7597964 0.0002918654 2.646850e-02 6.488499e-02 6 167922856 167922953 98 + 2.082 2.094 0.040
ENSG00000130396 E041 76.0413776 0.0014731354 1.141916e-01 2.116551e-01 6 167922954 167922959 6 + 1.836 1.847 0.038
ENSG00000130396 E042 3.6902438 0.0044177707 3.869112e-02 8.861010e-02 6 167922960 167923207 248 + 0.485 0.860 1.605
ENSG00000130396 E043 132.7215259 0.0007399154 7.492952e-02 1.514168e-01 6 167925005 167925091 87 + 2.074 2.098 0.081
ENSG00000130396 E044 0.1472490 0.0432496249 1.000000e+00   6 167932602 167932760 159 + 0.074 0.000 -13.313
ENSG00000130396 E045 119.0636930 0.0017012360 7.400479e-01 8.295751e-01 6 167943129 167943191 63 + 2.013 2.088 0.251
ENSG00000130396 E046 66.2450268 0.0078097932 4.626647e-01 6.025245e-01 6 167943192 167943194 3 + 1.741 1.877 0.458
ENSG00000130396 E047 123.2358054 0.0011416575 2.004109e-01 3.267293e-01 6 167943402 167943475 74 + 2.038 2.078 0.132
ENSG00000130396 E048 152.7883896 0.0002242105 8.715352e-04 3.514673e-03 6 167943941 167944059 119 + 2.147 2.128 -0.064
ENSG00000130396 E049 179.8037291 0.0002072255 2.010298e-01 3.274564e-01 6 167946707 167946901 195 + 2.197 2.248 0.170
ENSG00000130396 E050 125.0782120 0.0002756354 6.177485e-01 7.354911e-01 6 167947853 167947944 92 + 2.022 2.127 0.351
ENSG00000130396 E051 5.1735376 0.0029785159 4.649076e-03 1.495616e-02 6 167948029 167948292 264 + 0.832 0.432 -1.764
ENSG00000130396 E052 207.1954436 0.0002073654 9.044348e-01 9.431470e-01 6 167948293 167948478 186 + 2.246 2.337 0.305
ENSG00000130396 E053 381.6339244 0.0025514369 1.326467e-01 2.377797e-01 6 167951186 167951903 718 + 2.495 2.629 0.445
ENSG00000130396 E054 83.5504172 0.0003127967 1.498437e-03 5.630754e-03 6 167951904 167951948 45 + 1.809 2.025 0.727
ENSG00000130396 E055 241.4436059 0.0001891376 5.463998e-06 3.855837e-05 6 167951949 167952187 239 + 2.273 2.471 0.661
ENSG00000130396 E056 2.0919227 0.0068270366 1.059482e-03 4.164743e-03 6 167952188 167952262 75 + 0.193 0.786 3.190
ENSG00000130396 E057 0.3268771 0.0294853058 5.063993e-01   6 167954458 167954460 3 + 0.074 0.195 1.605
ENSG00000130396 E058 0.6224193 0.0172671820 3.770446e-01 5.213810e-01 6 167954461 167954493 33 + 0.138 0.329 1.603
ENSG00000130396 E059 81.3210467 0.0003121301 1.288595e-01 2.325688e-01 6 167962433 167962438 6 + 1.823 1.973 0.507
ENSG00000130396 E060 154.5164743 0.0002374957 2.002962e-02 5.155149e-02 6 167962439 167962567 129 + 2.095 2.253 0.531
ENSG00000130396 E061 88.9097962 0.0024420228 2.403859e-08 2.758185e-07 6 167962568 167965029 2462 + 1.783 2.120 1.130
ENSG00000130396 E062 54.7148040 0.0074359850 6.173210e-02 1.295410e-01 6 167965757 167965830 74 + 1.629 1.835 0.698
ENSG00000130396 E063 22.2447107 0.0013678561 8.022574e-04 3.267587e-03 6 167965831 167965853 23 + 1.202 1.537 1.165
ENSG00000130396 E064 45.5407635 0.0005409434 4.276162e-03 1.391743e-02 6 167965854 167965963 110 + 1.541 1.782 0.819
ENSG00000130396 E065 69.1370505 0.0003699008 9.564307e-03 2.769475e-02 6 167965964 167966045 82 + 1.732 1.935 0.684
ENSG00000130396 E066 30.0436310 0.0006871988 7.400196e-01 8.295483e-01 6 167966046 167966270 225 + 1.415 1.523 0.371
ENSG00000130396 E067 8.7990511 0.0019333290 1.060196e-01 1.996391e-01 6 167966271 167966276 6 + 0.982 0.860 -0.460
ENSG00000130396 E068 28.3859493 0.0006769523 5.569219e-02 1.191700e-01 6 167968449 167968802 354 + 1.439 1.385 -0.188
ENSG00000130396 E069 25.3312081 0.0008399486 2.174828e-01 3.473513e-01 6 167968803 167969018 216 + 1.383 1.375 -0.028
ENSG00000130396 E070 15.1439149 0.0011629793 8.977301e-01 9.387112e-01 6 167969019 167969113 95 + 1.142 1.213 0.251
ENSG00000130396 E071 127.7724402 0.0004944916 5.395864e-02 1.161942e-01 6 167969114 167969198 85 + 2.015 2.169 0.515
ENSG00000130396 E072 1495.7768275 0.0109519240 5.049097e-15 1.736631e-13 6 167969782 167972023 2242 + 2.969 3.382 1.373