ENSG00000130340

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392185 ENSG00000130340 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX9 protein_coding protein_coding 12.95101 8.489963 17.03216 0.5890794 0.3333549 1.00358 10.0523792 5.66921107 12.999488 1.34002999 0.3699151 1.195802 0.74468750 0.693066667 0.7631000 0.07003333 1.000000e+00 2.57613e-19 FALSE TRUE
ENST00000679691 ENSG00000130340 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX9 protein_coding protein_coding 12.95101 8.489963 17.03216 0.5890794 0.3333549 1.00358 0.6800612 1.98417107 0.000000 1.98417107 0.0000000 -7.639645 0.08353750 0.206133333 0.0000000 -0.20613333 7.269781e-01 2.57613e-19 FALSE TRUE
ENST00000680095 ENSG00000130340 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX9 protein_coding retained_intron 12.95101 8.489963 17.03216 0.5890794 0.3333549 1.00358 0.5458354 0.01018651 2.083768 0.01018651 0.0985899 6.696567 0.03280417 0.001066667 0.1223333 0.12126667 2.576130e-19 2.57613e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130340 E001 0.0000000       6 157700387 157700471 85 +      
ENSG00000130340 E002 0.0000000       6 157716046 157716203 158 +      
ENSG00000130340 E003 0.1482932 0.0410584276 2.826936e-01   6 157766385 157766536 152 + 0.000 0.157 11.729
ENSG00000130340 E004 0.1482932 0.0410584276 2.826936e-01   6 157779824 157779867 44 + 0.000 0.157 11.750
ENSG00000130340 E005 1.9399494 0.0527726641 2.377791e-03 8.391993e-03 6 157823161 157823205 45 + 0.618 0.000 -14.027
ENSG00000130340 E006 2.3797339 0.0249763617 4.550479e-04 1.986713e-03 6 157823206 157823220 15 + 0.688 0.000 -14.326
ENSG00000130340 E007 2.2584075 0.0067954538 7.557371e-03 2.266458e-02 6 157823221 157823221 1 + 0.643 0.158 -2.955
ENSG00000130340 E008 5.5924957 0.0040960852 8.661285e-05 4.592082e-04 6 157823222 157823243 22 + 0.966 0.364 -2.651
ENSG00000130340 E009 6.1010772 0.0032749880 8.118546e-04 3.301424e-03 6 157823244 157823245 2 + 0.977 0.503 -1.955
ENSG00000130340 E010 37.2533455 0.0185234128 4.573351e-05 2.601512e-04 6 157823246 157823389 144 + 1.685 1.311 -1.288
ENSG00000130340 E011 38.2147515 0.0322464141 2.535435e-02 6.260173e-02 6 157823390 157823446 57 + 1.661 1.429 -0.794
ENSG00000130340 E012 0.0000000       6 157829661 157829706 46 +      
ENSG00000130340 E013 65.2790074 0.0047573813 6.569461e-06 4.552175e-05 6 157867547 157867633 87 + 1.895 1.643 -0.850
ENSG00000130340 E014 74.8751424 0.0049929210 7.462460e-03 2.241862e-02 6 157873102 157873176 75 + 1.922 1.787 -0.455
ENSG00000130340 E015 100.9131798 0.0010441783 1.428637e-02 3.887770e-02 6 157875051 157875176 126 + 2.032 1.949 -0.278
ENSG00000130340 E016 2.8743677 0.0053823040 7.939984e-01 8.683590e-01 6 157876169 157876478 310 + 0.592 0.559 -0.148
ENSG00000130340 E017 0.0000000       6 157888571 157888660 90 +      
ENSG00000130340 E018 128.0213724 0.0002755039 3.222814e-03 1.092340e-02 6 157896827 157896998 172 + 2.133 2.049 -0.278
ENSG00000130340 E019 69.0526299 0.0092797220 1.952885e-01 3.203299e-01 6 157901898 157901927 30 + 1.863 1.788 -0.253
ENSG00000130340 E020 109.5170712 0.0004381871 9.527502e-03 2.760548e-02 6 157901928 157902045 118 + 2.064 1.984 -0.268
ENSG00000130340 E021 91.0822432 0.0003420859 1.112362e-02 3.146171e-02 6 157906128 157906212 85 + 1.989 1.904 -0.285
ENSG00000130340 E022 4.0569675 0.0181863616 1.772025e-01 2.975895e-01 6 157906213 157907730 1518 + 0.767 0.559 -0.883
ENSG00000130340 E023 4.4414677 0.0046067549 3.931665e-01 5.370553e-01 6 157907731 157909664 1934 + 0.767 0.653 -0.470
ENSG00000130340 E024 129.4965094 0.0002480195 2.608563e-05 1.574789e-04 6 157909665 157909790 126 + 2.154 2.030 -0.413
ENSG00000130340 E025 132.4037494 0.0002940783 9.886802e-04 3.919856e-03 6 157909908 157910025 118 + 2.152 2.059 -0.311
ENSG00000130340 E026 0.4502799 0.0350308742 2.160055e-01 3.455866e-01 6 157910026 157910347 322 + 0.237 0.000 -11.910
ENSG00000130340 E027 138.2680174 0.0048025922 2.008263e-02 5.166283e-02 6 157921531 157921661 131 + 2.172 2.077 -0.318
ENSG00000130340 E028 114.1909629 0.0009368359 2.885510e-02 6.970990e-02 6 157927111 157927214 104 + 2.081 2.014 -0.224
ENSG00000130340 E029 0.8793520 0.2381979280 3.314106e-01 4.750159e-01 6 157927763 157928598 836 + 0.171 0.369 1.465
ENSG00000130340 E030 110.2362319 0.0002583263 8.168543e-01 8.841628e-01 6 157928599 157928702 104 + 2.032 2.053 0.070
ENSG00000130340 E031 98.3966306 0.0003448208 2.378210e-01 3.716263e-01 6 157932195 157932272 78 + 1.964 2.020 0.186
ENSG00000130340 E032 0.7760110 0.0162466624 8.685940e-01 9.195344e-01 6 157932273 157932672 400 + 0.237 0.273 0.266
ENSG00000130340 E033 119.0670134 0.0002860144 1.995165e-01 3.256270e-01 6 157935964 157936040 77 + 2.047 2.102 0.184
ENSG00000130340 E034 131.9391883 0.0002379275 3.292817e-01 4.727804e-01 6 157937434 157937523 90 + 2.099 2.142 0.145
ENSG00000130340 E035 0.9265960 0.0782069518 3.267268e-01 4.701808e-01 6 157937524 157937946 423 + 0.345 0.158 -1.470
ENSG00000130340 E036 0.6621601 0.0163900791 5.816380e-01 7.061579e-01 6 157937947 157938632 686 + 0.172 0.273 0.852
ENSG00000130340 E037 142.5209188 0.0002465360 4.469658e-01 5.883979e-01 6 157938633 157938747 115 + 2.136 2.172 0.120
ENSG00000130340 E038 12.2530682 0.0023045659 8.527002e-01 9.086993e-01 6 157938748 157940882 2135 + 1.093 1.122 0.106
ENSG00000130340 E039 77.1992076 0.0003452801 2.854971e-01 4.258282e-01 6 157940883 157940904 22 + 1.862 1.918 0.189
ENSG00000130340 E040 99.4943331 0.0002656278 6.539616e-01 7.642831e-01 6 157940905 157940974 70 + 1.983 2.012 0.097
ENSG00000130340 E041 2.5538334 0.0060811243 6.727863e-01 7.786413e-01 6 157940975 157941239 265 + 0.564 0.503 -0.285
ENSG00000130340 E042 1.7349610 0.0081032854 1.926125e-01 3.170387e-01 6 157941240 157941258 19 + 0.502 0.273 -1.317
ENSG00000130340 E043 22.2675782 0.0011238331 4.024073e-05 2.317944e-04 6 157941259 157942790 1532 + 1.205 1.517 1.088
ENSG00000130340 E044 228.9543297 0.0002234371 3.324928e-13 8.776614e-12 6 157942791 157943453 663 + 2.274 2.456 0.609
ENSG00000130340 E045 282.4867078 0.0074641168 3.526597e-04 1.590722e-03 6 157943454 157944027 574 + 2.366 2.542 0.586
ENSG00000130340 E046 187.6445957 0.0058647257 2.337730e-06 1.792077e-05 6 157944028 157945077 1050 + 2.167 2.389 0.744