ENSG00000130338

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367094 ENSG00000130338 HEK293_OSMI2_2hA HEK293_TMG_2hB TULP4 protein_coding protein_coding 3.864037 2.755105 5.557388 0.2066756 0.2322699 1.009667 0.8311343 1.44784780 0.3504000 0.18768365 0.17599396 -2.016169 0.25531250 0.53056667 0.06506667 -0.465500000 2.770909e-02 2.205439e-06 FALSE TRUE
ENST00000367097 ENSG00000130338 HEK293_OSMI2_2hA HEK293_TMG_2hB TULP4 protein_coding protein_coding 3.864037 2.755105 5.557388 0.2066756 0.2322699 1.009667 1.4484645 0.91597301 1.8733904 0.16993352 0.08932906 1.024290 0.37379583 0.33410000 0.33716667 0.003066667 9.690169e-01 2.205439e-06 FALSE TRUE
ENST00000432358 ENSG00000130338 HEK293_OSMI2_2hA HEK293_TMG_2hB TULP4 protein_coding processed_transcript 3.864037 2.755105 5.557388 0.2066756 0.2322699 1.009667 0.6957982 0.12495484 1.6682932 0.06263052 0.17291148 3.636446 0.15992083 0.04366667 0.29876667 0.255100000 2.205439e-06 2.205439e-06   FALSE
ENST00000620026 ENSG00000130338 HEK293_OSMI2_2hA HEK293_TMG_2hB TULP4 protein_coding processed_transcript 3.864037 2.755105 5.557388 0.2066756 0.2322699 1.009667 0.5692413 0.15407966 0.9120659 0.06018333 0.07439612 2.490474 0.13811250 0.05416667 0.16390000 0.109733333 6.862598e-03 2.205439e-06   FALSE
MSTRG.29244.7 ENSG00000130338 HEK293_OSMI2_2hA HEK293_TMG_2hB TULP4 protein_coding   3.864037 2.755105 5.557388 0.2066756 0.2322699 1.009667 0.2201023 0.04654806 0.4519606 0.02709784 0.17612031 3.030221 0.05183333 0.01606667 0.08133333 0.065266667 2.025340e-01 2.205439e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130338 E001 5.0948915 0.0035015362 8.257257e-01 8.902758e-01 6 158232236 158232303 68 + 0.662 0.925 1.043
ENSG00000130338 E002 3.6987436 0.0042537959 5.476577e-04 2.338181e-03 6 158282263 158282378 116 + 0.716 0.413 -1.400
ENSG00000130338 E003 1.0340766 0.0191799189 5.475944e-01 6.776236e-01 6 158310364 158310483 120 + 0.255 0.314 0.411
ENSG00000130338 E004 18.2806016 0.0037298411 4.951452e-12 1.083685e-10 6 158312051 158312464 414 + 1.326 1.001 -1.162
ENSG00000130338 E005 11.9740922 0.0179438750 2.231368e-03 7.940605e-03 6 158312465 158312659 195 + 1.086 1.048 -0.138
ENSG00000130338 E006 32.9333080 0.0030151429 1.052428e-14 3.450065e-13 6 158312660 158313444 785 + 1.551 1.347 -0.706
ENSG00000130338 E007 26.5073649 0.0009998192 1.302717e-13 3.645433e-12 6 158313445 158314058 614 + 1.462 1.254 -0.722
ENSG00000130338 E008 12.0788220 0.0015768637 1.863311e-06 1.459698e-05 6 158314059 158314268 210 + 1.127 0.952 -0.640
ENSG00000130338 E009 9.4002521 0.0023285989 9.276582e-05 4.880504e-04 6 158413065 158413193 129 + 1.025 0.897 -0.478
ENSG00000130338 E010 12.5972356 0.0420830496 6.907495e-05 3.755608e-04 6 158429736 158429897 162 + 1.169 0.924 -0.899
ENSG00000130338 E011 14.6316639 0.0012332328 9.931582e-07 8.244275e-06 6 158448996 158449176 181 + 1.198 1.064 -0.480
ENSG00000130338 E012 13.4096525 0.0013898410 2.099041e-06 1.625412e-05 6 158452134 158452268 135 + 1.164 1.023 -0.510
ENSG00000130338 E013 10.9799589 0.0576583729 5.120396e-03 1.625708e-02 6 158461563 158461649 87 + 1.071 0.962 -0.400
ENSG00000130338 E014 11.0478164 0.0368615836 1.262057e-04 6.421781e-04 6 158461650 158461729 80 + 1.106 0.871 -0.871
ENSG00000130338 E015 2.6820542 0.0232289163 1.972977e-01 3.228568e-01 6 158476434 158476612 179 + 0.531 0.563 0.146
ENSG00000130338 E016 14.1466596 0.0074978086 4.280021e-04 1.882035e-03 6 158479751 158479975 225 + 1.152 1.122 -0.108
ENSG00000130338 E017 14.2610056 0.0017347539 3.593085e-06 2.643389e-05 6 158481055 158481289 235 + 1.182 1.065 -0.420
ENSG00000130338 E018 0.6224193 0.0181472363 8.646535e-01 9.167615e-01 6 158481290 158481538 249 + 0.146 0.314 1.406
ENSG00000130338 E019 10.3996640 0.0021885753 5.843727e-07 5.103852e-06 6 158489588 158489732 145 + 1.086 0.835 -0.941
ENSG00000130338 E020 9.7994645 0.0020772866 4.223750e-05 2.421110e-04 6 158493573 158493717 145 + 1.041 0.897 -0.536
ENSG00000130338 E021 9.3214583 0.0794418815 1.694292e-01 2.874503e-01 6 158494753 158494846 94 + 0.962 1.041 0.291
ENSG00000130338 E022 9.7241053 0.0020988257 4.912264e-03 1.568617e-02 6 158498669 158498812 144 + 0.991 1.001 0.036
ENSG00000130338 E023 91.4720865 0.0108264263 3.529976e-03 1.181254e-02 6 158501678 158504178 2501 + 1.865 2.045 0.603
ENSG00000130338 E024 443.0284919 0.0280607891 4.543244e-15 1.573787e-13 6 158506578 158511828 5251 + 2.295 2.946 2.166