ENSG00000130270

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000526092 ENSG00000130270 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8B3 protein_coding protein_coding 0.5010574 0.6898124 0.4712224 0.0804065 0.04316971 -0.5402643 0.15825790 0.31784737 0.08970898 0.04805915 0.046584570 -1.717229 0.33431667 0.45793333 0.194266667 -0.26366667 0.16249496 0.01902204 FALSE TRUE
ENST00000531925 ENSG00000130270 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8B3 protein_coding nonsense_mediated_decay 0.5010574 0.6898124 0.4712224 0.0804065 0.04316971 -0.5402643 0.02439033 0.03557466 0.00336932 0.02312690 0.003369320 -1.769306 0.06461250 0.04690000 0.006866667 -0.04003333 0.50087643 0.01902204 TRUE TRUE
ENST00000533107 ENSG00000130270 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8B3 protein_coding retained_intron 0.5010574 0.6898124 0.4712224 0.0804065 0.04316971 -0.5402643 0.19939788 0.26603050 0.12173939 0.04076758 0.066861630 -1.067141 0.36857500 0.40910000 0.240600000 -0.16850000 0.68064648 0.01902204 FALSE TRUE
ENST00000533993 ENSG00000130270 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8B3 protein_coding processed_transcript 0.5010574 0.6898124 0.4712224 0.0804065 0.04316971 -0.5402643 0.02480456 0.00000000 0.00000000 0.00000000 0.000000000 0.000000 0.05014167 0.00000000 0.000000000 0.00000000   0.01902204 FALSE FALSE
ENST00000587160 ENSG00000130270 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP8B3 protein_coding protein_coding 0.5010574 0.6898124 0.4712224 0.0804065 0.04316971 -0.5402643 0.08320939 0.06401180 0.24255872 0.06401180 0.005151734 1.770792 0.15453333 0.07676667 0.525100000 0.44833333 0.01902204 0.01902204 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130270 E001 0.0000000       19 1782075 1782076 2 -      
ENSG00000130270 E002 0.8868276 0.016204418 0.16939396 0.28740085 19 1782077 1783027 951 - 0.402 0.152 -1.864
ENSG00000130270 E003 0.0000000       19 1783028 1783270 243 -      
ENSG00000130270 E004 0.1515154 0.042472797 0.20971739   19 1784819 1784946 128 - 0.178 0.000 -13.648
ENSG00000130270 E005 0.1515154 0.042472797 0.20971739   19 1785159 1785297 139 - 0.178 0.000 -13.648
ENSG00000130270 E006 0.1482932 0.042311136 1.00000000   19 1785469 1785557 89 - 0.000 0.082 10.844
ENSG00000130270 E007 0.1482932 0.042311136 1.00000000   19 1785558 1785708 151 - 0.000 0.082 10.844
ENSG00000130270 E008 0.2214452 0.039068290 1.00000000   19 1787103 1787186 84 - 0.000 0.083 10.850
ENSG00000130270 E009 0.3697384 0.027442404 0.54668872 0.67681238 19 1788897 1789120 224 - 0.000 0.151 11.686
ENSG00000130270 E010 0.3268771 0.034344573 0.53920430   19 1789361 1789614 254 - 0.178 0.082 -1.282
ENSG00000130270 E011 0.1451727 0.047927700 0.20871064   19 1789615 1789727 113 - 0.178 0.000 -13.643
ENSG00000130270 E012 0.1817044 0.051188477 1.00000000   19 1789890 1789989 100 - 0.000 0.082 10.843
ENSG00000130270 E013 0.0000000       19 1790757 1790817 61 -      
ENSG00000130270 E014 0.0000000       19 1790818 1790832 15 -      
ENSG00000130270 E015 0.1451727 0.047927700 0.20871064   19 1791750 1791861 112 - 0.178 0.000 -13.643
ENSG00000130270 E016 0.0000000       19 1791971 1792000 30 -      
ENSG00000130270 E017 0.0000000       19 1792001 1792135 135 -      
ENSG00000130270 E018 0.0000000       19 1795875 1795987 113 -      
ENSG00000130270 E019 0.1451727 0.047927700 0.20871064   19 1796077 1796265 189 - 0.178 0.000 -13.643
ENSG00000130270 E020 0.1451727 0.047927700 0.20871064   19 1796711 1796879 169 - 0.178 0.000 -13.643
ENSG00000130270 E021 0.1482932 0.042311136 1.00000000   19 1796974 1797005 32 - 0.000 0.082 10.844
ENSG00000130270 E022 0.3697384 0.027442404 0.54668872 0.67681238 19 1798761 1798763 3 - 0.000 0.151 11.686
ENSG00000130270 E023 14.7954427 0.001516763 0.10494137 0.19800241 19 1798764 1799946 1183 - 1.047 1.175 0.460
ENSG00000130270 E024 4.6143300 0.004620138 0.96037490 0.97903631 19 1799947 1800155 209 - 0.704 0.696 -0.035
ENSG00000130270 E025 4.1265865 0.011733547 0.36320253 0.50763680 19 1800259 1800449 191 - 0.549 0.678 0.570
ENSG00000130270 E026 2.3229329 0.007552994 0.96087692 0.97936009 19 1801956 1802044 89 - 0.482 0.459 -0.111
ENSG00000130270 E027 0.0000000       19 1802045 1802062 18 -      
ENSG00000130270 E028 3.3902317 0.004841797 0.99612193 1.00000000 19 1802487 1802645 159 - 0.607 0.593 -0.061
ENSG00000130270 E029 0.0000000       19 1805190 1805279 90 -      
ENSG00000130270 E030 3.3286312 0.029381282 0.13570320 0.24208587 19 1805374 1805456 83 - 0.402 0.655 1.207
ENSG00000130270 E031 3.6544641 0.005271545 0.43685877 0.57888997 19 1805888 1805958 71 - 0.549 0.657 0.481
ENSG00000130270 E032 1.5875216 0.063603271 0.54309207 0.67375030 19 1805959 1806096 138 - 0.482 0.351 -0.710
ENSG00000130270 E033 2.4430263 0.007061694 0.78062542 0.85903484 19 1806097 1806160 64 - 0.549 0.489 -0.285
ENSG00000130270 E034 0.9995446 0.013696863 0.45533957 0.59586868 19 1806161 1806169 9 - 0.178 0.310 1.037
ENSG00000130270 E035 0.3697384 0.027442404 0.54668872 0.67681238 19 1806170 1806508 339 - 0.000 0.151 11.686
ENSG00000130270 E036 1.8842071 0.008234307 0.36504535 0.50938567 19 1806628 1806689 62 - 0.304 0.459 0.886
ENSG00000130270 E037 2.9473387 0.005608998 0.07114741 0.14524578 19 1807168 1807266 99 - 0.304 0.616 1.623
ENSG00000130270 E038 3.7307236 0.005117639 0.20020358 0.32649092 19 1808222 1808335 114 - 0.482 0.677 0.886
ENSG00000130270 E039 2.4669597 0.007243862 0.90097964 0.94084903 19 1809643 1809734 92 - 0.482 0.490 0.041
ENSG00000130270 E040 2.8357426 0.101372560 0.30380373 0.44578038 19 1810622 1810683 62 - 0.658 0.467 -0.880
ENSG00000130270 E041 2.1756733 0.007243862 0.07350778 0.14913602 19 1811489 1811600 112 - 0.658 0.353 -1.504
ENSG00000130270 E042 2.6175170 0.014753013 0.90514024 0.94362293 19 1811601 1811624 24 - 0.481 0.491 0.047
ENSG00000130270 E043 2.2498695 0.008641561 0.22254977 0.35343901 19 1811625 1811666 42 - 0.607 0.391 -1.058
ENSG00000130270 E044 2.5517545 0.006525951 0.17462014 0.29419687 19 1811667 1811884 218 - 0.658 0.427 -1.089
ENSG00000130270 E045 0.2966881 0.029078516 0.05539676   19 1812068 1812185 118 - 0.304 0.000 -14.437
ENSG00000130270 E046 0.4449813 0.021826439 0.19424035 0.31906368 19 1812186 1812200 15 - 0.304 0.082 -2.285
ENSG00000130270 E047 0.7374030 0.017267182 0.02167089 0.05499349 19 1812201 1812237 37 - 0.481 0.082 -3.284
ENSG00000130270 E048 0.5922303 0.018491238 0.06558199 0.13601523 19 1812238 1812276 39 - 0.402 0.082 -2.869