ENSG00000130224

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317135 ENSG00000130224 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH2 protein_coding protein_coding 6.927274 1.278742 13.07942 0.1398315 0.6784832 3.344365 1.802862 0.3178792 4.4059508 0.09020488 0.7376542 3.7514876 0.3184917 0.26596667 0.33720000 0.07123333 7.736086e-01 6.128225e-07 FALSE TRUE
MSTRG.34739.1 ENSG00000130224 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH2 protein_coding   6.927274 1.278742 13.07942 0.1398315 0.6784832 3.344365 1.190958 0.8911622 0.7864663 0.15965427 0.7864663 -0.1781735 0.3312417 0.68690000 0.06306667 -0.62383333 1.633127e-02 6.128225e-07 FALSE TRUE
MSTRG.34739.4 ENSG00000130224 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH2 protein_coding   6.927274 1.278742 13.07942 0.1398315 0.6784832 3.344365 2.240702 0.0000000 4.5205553 0.00000000 1.1673852 8.8235441 0.1978625 0.00000000 0.33870000 0.33870000 6.128225e-07 6.128225e-07 FALSE TRUE
MSTRG.34739.5 ENSG00000130224 HEK293_OSMI2_2hA HEK293_TMG_2hB LRCH2 protein_coding   6.927274 1.278742 13.07942 0.1398315 0.6784832 3.344365 1.692753 0.0697010 3.3664479 0.05699419 0.3734224 5.4047647 0.1524167 0.04716667 0.26110000 0.21393333 9.215450e-03 6.128225e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130224 E001 0.5900522 0.3904430115 4.721620e-02 0.1042160449 X 115110616 115110625 10 - 0.048 0.552 4.449
ENSG00000130224 E002 202.2030577 0.0409804796 4.932331e-05 0.0002783234 X 115110626 115113199 2574 - 2.056 2.487 1.440
ENSG00000130224 E003 24.6765565 0.0116153539 2.357795e-01 0.3692981668 X 115113200 115113335 136 - 1.257 1.235 -0.075
ENSG00000130224 E004 27.8592762 0.0212655756 7.842145e-01 0.8615630900 X 115122527 115122604 78 - 1.294 1.370 0.263
ENSG00000130224 E005 41.5900858 0.0086157881 7.702885e-01 0.8516419870 X 115122760 115122897 138 - 1.459 1.545 0.296
ENSG00000130224 E006 43.1931375 0.0037041443 2.271553e-02 0.0571620752 X 115123080 115123192 113 - 1.495 1.418 -0.266
ENSG00000130224 E007 31.0218616 0.0189518777 7.012283e-02 0.1435687486 X 115123945 115124002 58 - 1.358 1.260 -0.344
ENSG00000130224 E008 24.3941539 0.0198583687 3.231488e-01 0.4664880980 X 115126843 115126893 51 - 1.249 1.237 -0.043
ENSG00000130224 E009 22.1474654 0.0008190465 1.230904e-01 0.2243603067 X 115130155 115130199 45 - 1.216 1.161 -0.194
ENSG00000130224 E010 1.2910239 0.0102709389 4.416482e-01 0.5832863105 X 115136484 115136543 60 - 0.232 0.447 1.349
ENSG00000130224 E011 3.0646049 0.0052150667 1.742934e-02 0.0458882643 X 115138339 115138442 104 - 0.383 0.863 2.155
ENSG00000130224 E012 34.3568593 0.0158271574 2.229739e-01 0.3539227320 X 115149827 115149943 117 - 1.392 1.372 -0.071
ENSG00000130224 E013 24.7669152 0.0009760195 7.059851e-02 0.1443351984 X 115150022 115150070 49 - 1.263 1.187 -0.267
ENSG00000130224 E014 27.5651001 0.0060419558 5.128631e-02 0.1114454553 X 115156602 115156667 66 - 1.308 1.213 -0.332
ENSG00000130224 E015 39.2202315 0.0655134914 1.541082e-01 0.2672464801 X 115163676 115163783 108 - 1.456 1.376 -0.275
ENSG00000130224 E016 30.2808596 0.0006760906 5.341909e-02 0.1152353765 X 115165405 115165463 59 - 1.346 1.278 -0.237
ENSG00000130224 E017 39.6298869 0.0008829609 1.562294e-02 0.0418944822 X 115165558 115165655 98 - 1.459 1.371 -0.306
ENSG00000130224 E018 41.4988467 0.0007279666 1.202773e-02 0.0335973508 X 115165841 115165952 112 - 1.478 1.387 -0.315
ENSG00000130224 E019 34.3904439 0.0006558839 2.909977e-02 0.0701962668 X 115166255 115166342 88 - 1.398 1.318 -0.280
ENSG00000130224 E020 33.7857806 0.0128094121 1.223275e-01 0.2232640230 X 115170299 115170432 134 - 1.388 1.338 -0.172
ENSG00000130224 E021 28.0712640 0.0892798094 5.519146e-01 0.6813142482 X 115179427 115179563 137 - 1.298 1.337 0.138
ENSG00000130224 E022 24.3284228 0.0008414010 6.465143e-01 0.7583979979 X 115179646 115179751 106 - 1.234 1.299 0.227
ENSG00000130224 E023 30.0327511 0.0008525726 7.540947e-01 0.8398201739 X 115184411 115184537 127 - 1.320 1.403 0.287
ENSG00000130224 E024 27.5071857 0.0014792482 1.010143e-01 0.1920079985 X 115188226 115188370 145 - 1.305 1.257 -0.168
ENSG00000130224 E025 22.5221877 0.0009119525 2.583231e-01 0.3955588829 X 115233693 115233867 175 - 1.219 1.212 -0.025
ENSG00000130224 E026 9.0331738 0.0026535505 2.954325e-01 0.4365605103 X 115233868 115234096 229 - 0.867 0.806 -0.238
ENSG00000130224 E027 0.2987644 0.0272688117 1.000000e+00   X 115234291 115234350 60 - 0.092 0.001 -7.358