ENSG00000130204

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000252487 ENSG00000130204 HEK293_OSMI2_2hA HEK293_TMG_2hB TOMM40 protein_coding protein_coding 283.0191 508.4794 179.9303 12.57579 1.455166 -1.498699 13.13983 11.00643 21.32189 4.043364 1.819608 0.9533551 0.0477625 0.0213000 0.1184 0.0971000 3.966766e-03 3.502736e-35 FALSE TRUE
ENST00000405636 ENSG00000130204 HEK293_OSMI2_2hA HEK293_TMG_2hB TOMM40 protein_coding protein_coding 283.0191 508.4794 179.9303 12.57579 1.455166 -1.498699 68.50580 63.12715 97.21654 22.373044 2.962067 0.6228610 0.2413875 0.1225333 0.5404 0.4178667 2.371803e-04 3.502736e-35 FALSE TRUE
ENST00000426677 ENSG00000130204 HEK293_OSMI2_2hA HEK293_TMG_2hB TOMM40 protein_coding protein_coding 283.0191 508.4794 179.9303 12.57579 1.455166 -1.498699 46.75695 62.83166 51.04957 10.920098 1.618649 -0.2995398 0.1699708 0.1228000 0.2836 0.1608000 1.311063e-04 3.502736e-35 FALSE TRUE
MSTRG.17298.6 ENSG00000130204 HEK293_OSMI2_2hA HEK293_TMG_2hB TOMM40 protein_coding   283.0191 508.4794 179.9303 12.57579 1.455166 -1.498699 144.65036 359.86496 0.00000 27.352678 0.000000 -15.1352081 0.4989792 0.7105000 0.0000 -0.7105000 3.502736e-35 3.502736e-35 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130204 E001 0.9556391 1.255889e-02 2.018956e-01 3.285644e-01 19 44890569 44890656 88 + 0.430 0.194 -1.591
ENSG00000130204 E002 0.1817044 4.026770e-02 1.000000e+00   19 44890950 44890960 11 + 0.000 0.075 8.044
ENSG00000130204 E003 0.3299976 2.744240e-02 6.990841e-01   19 44890961 44890995 35 + 0.000 0.138 9.218
ENSG00000130204 E004 0.0000000       19 44891089 44891141 53 +      
ENSG00000130204 E005 0.0000000       19 44891142 44891174 33 +      
ENSG00000130204 E006 0.1817044 4.026770e-02 1.000000e+00   19 44891220 44891223 4 + 0.000 0.075 8.044
ENSG00000130204 E007 2.3552999 9.262001e-02 3.731590e-01 5.176003e-01 19 44891224 44891230 7 + 0.583 0.405 -0.875
ENSG00000130204 E008 8.1644132 2.477330e-02 1.911107e-04 9.259205e-04 19 44891231 44891236 6 + 1.211 0.713 -1.870
ENSG00000130204 E009 35.2778061 3.312319e-02 1.105757e-06 9.094850e-06 19 44891237 44891253 17 + 1.815 1.298 -1.769
ENSG00000130204 E010 265.9390493 4.225460e-02 1.194693e-07 1.196568e-06 19 44891254 44891314 61 + 2.697 2.155 -1.807
ENSG00000130204 E011 200.5052514 1.377563e-02 6.967115e-08 7.293468e-07 19 44891315 44891406 92 + 2.462 2.117 -1.154
ENSG00000130204 E012 289.6954344 2.913955e-02 1.026088e-08 1.262186e-07 19 44891407 44891409 3 + 2.710 2.213 -1.657
ENSG00000130204 E013 2090.0254069 5.521139e-03 3.578676e-09 4.786906e-08 19 44891410 44891689 280 + 3.395 3.179 -0.718
ENSG00000130204 E014 10.0962808 6.567424e-02 4.679690e-01 6.074029e-01 19 44891690 44891807 118 + 0.858 0.990 0.496
ENSG00000130204 E015 2139.7328951 1.068420e-03 7.030055e-08 7.351638e-07 19 44892393 44892460 68 + 3.323 3.220 -0.339
ENSG00000130204 E016 2957.1796778 4.587073e-04 2.031013e-10 3.399923e-09 19 44892837 44892929 93 + 3.450 3.365 -0.284
ENSG00000130204 E017 2489.2343630 3.789305e-04 1.918402e-03 6.972518e-03 19 44893780 44893828 49 + 3.346 3.300 -0.153
ENSG00000130204 E018 2694.3686869 1.996888e-04 2.735358e-01 4.125806e-01 19 44893829 44893881 53 + 3.360 3.339 -0.068
ENSG00000130204 E019 3725.7454888 4.737434e-05 7.038670e-06 4.845403e-05 19 44893961 44894066 106 + 3.467 3.489 0.074
ENSG00000130204 E020 9.4935934 1.891225e-03 5.279200e-02 1.141256e-01 19 44894067 44894067 1 + 0.742 0.992 0.964
ENSG00000130204 E021 4057.7042734 2.515520e-04 1.545041e-09 2.212254e-08 19 44900730 44900852 123 + 3.485 3.533 0.160
ENSG00000130204 E022 3145.8800642 5.620305e-04 1.366065e-06 1.101733e-05 19 44901028 44901104 77 + 3.369 3.424 0.182
ENSG00000130204 E023 3281.5498440 3.079287e-04 2.252537e-20 1.503652e-18 19 44901208 44901310 103 + 3.358 3.449 0.303
ENSG00000130204 E024 55.0173678 5.301569e-04 8.362597e-16 3.192160e-14 19 44901311 44901387 77 + 1.941 1.532 -1.387
ENSG00000130204 E025 59.3594109 6.720463e-04 5.057134e-12 1.105665e-10 19 44901388 44901452 65 + 1.939 1.592 -1.172
ENSG00000130204 E026 324.5919456 3.615392e-03 4.889904e-25 5.370305e-23 19 44901453 44903029 1577 + 2.692 2.314 -1.260
ENSG00000130204 E027 6830.3501271 1.065869e-03 8.538906e-24 8.283002e-22 19 44903030 44903689 660 + 3.640 3.775 0.451