ENSG00000130202

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000252483 ENSG00000130202 HEK293_OSMI2_2hA HEK293_TMG_2hB NECTIN2 protein_coding protein_coding 43.67127 67.1482 33.17245 1.561733 1.173321 -1.017143 24.35517 32.62111 21.25631 3.754425 0.5881714 -0.6176786 0.5769958 0.4864333 0.6411333 0.15470000 0.121077223 0.000244617 FALSE  
ENST00000252485 ENSG00000130202 HEK293_OSMI2_2hA HEK293_TMG_2hB NECTIN2 protein_coding protein_coding 43.67127 67.1482 33.17245 1.561733 1.173321 -1.017143 15.57089 26.75517 10.27209 1.066061 0.2076875 -1.3802233 0.3433875 0.3981333 0.3100667 -0.08806667 0.000244617 0.000244617 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130202 E001 4.724885 0.1149250786 1.860051e-01 3.087488e-01 19 44846175 44846294 120 + 0.886 0.620 -1.079
ENSG00000130202 E002 6.706192 0.1271857773 3.672524e-01 5.116317e-01 19 44846295 44846296 2 + 0.960 0.780 -0.691
ENSG00000130202 E003 231.230784 0.0093098886 2.131356e-01 3.422448e-01 19 44846297 44846613 317 + 2.358 2.298 -0.198
ENSG00000130202 E004 681.251832 0.0021666896 4.037675e-02 9.170777e-02 19 44865271 44865660 390 + 2.818 2.769 -0.161
ENSG00000130202 E005 834.190920 0.0001258317 3.104812e-02 7.400882e-02 19 44871853 44872149 297 + 2.892 2.863 -0.094
ENSG00000130202 E006 332.522758 0.0020819370 6.547024e-01 7.648091e-01 19 44873916 44873941 26 + 2.483 2.471 -0.038
ENSG00000130202 E007 503.577513 0.0001474104 4.740749e-01 6.129364e-01 19 44873942 44874033 92 + 2.662 2.650 -0.041
ENSG00000130202 E008 422.149771 0.0001504192 6.329784e-01 7.477683e-01 19 44874330 44874378 49 + 2.583 2.573 -0.030
ENSG00000130202 E009 441.133806 0.0002547967 1.680906e-01 2.857089e-01 19 44874379 44874462 84 + 2.576 2.603 0.090
ENSG00000130202 E010 273.961635 0.0001769553 1.099523e-02 3.114981e-02 19 44874463 44874478 16 + 2.344 2.405 0.204
ENSG00000130202 E011 3.351622 0.0051176390 6.220498e-01 7.389079e-01 19 44874479 44874689 211 + 0.531 0.612 0.367
ENSG00000130202 E012 247.918999 0.0032743977 2.702973e-07 2.523880e-06 19 44878223 44878372 150 + 2.194 2.393 0.665
ENSG00000130202 E013 232.768815 0.0069088209 1.440629e-04 7.211784e-04 19 44878373 44878552 180 + 2.176 2.364 0.628
ENSG00000130202 E014 234.730580 0.0048669584 4.358523e-08 4.757866e-07 19 44878553 44878941 389 + 2.136 2.379 0.810
ENSG00000130202 E015 236.508118 0.0025833568 5.770168e-02 1.226842e-01 19 44882211 44882337 127 + 2.369 2.305 -0.214
ENSG00000130202 E016 144.132203 0.0029397155 2.809038e-01 4.207648e-01 19 44882338 44882364 27 + 2.142 2.098 -0.146
ENSG00000130202 E017 172.930903 0.0033625002 1.644582e-01 2.809793e-01 19 44885937 44886000 64 + 2.228 2.173 -0.182
ENSG00000130202 E018 186.166788 0.0016544544 2.143507e-01 3.436763e-01 19 44886133 44886219 87 + 2.249 2.208 -0.138
ENSG00000130202 E019 912.200067 0.0009727965 8.371230e-02 1.653586e-01 19 44888110 44889223 1114 + 2.932 2.903 -0.096