ENSG00000130177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000252458 ENSG00000130177 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC16 protein_coding protein_coding 22.79176 16.01125 31.53276 1.174655 0.8227538 0.9773226 1.822698 1.1121548 2.618220 0.18717358 0.5510147 1.2278143 0.07605000 0.06893333 0.08243333 0.013500000 8.206862e-01 7.962401e-06 FALSE TRUE
ENST00000356221 ENSG00000130177 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC16 protein_coding protein_coding 22.79176 16.01125 31.53276 1.174655 0.8227538 0.9773226 11.225908 10.1753302 14.039248 0.69522797 1.0226415 0.4640002 0.51137500 0.63630000 0.44543333 -0.190866667 1.086963e-03 7.962401e-06 FALSE TRUE
ENST00000375308 ENSG00000130177 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC16 protein_coding protein_coding 22.79176 16.01125 31.53276 1.174655 0.8227538 0.9773226 1.790385 1.1561934 1.748005 1.15619344 1.2074337 0.5921321 0.07518750 0.06313333 0.05676667 -0.006366667 6.970063e-01 7.962401e-06 FALSE TRUE
ENST00000494766 ENSG00000130177 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC16 protein_coding retained_intron 22.79176 16.01125 31.53276 1.174655 0.8227538 0.9773226 1.565280 0.3232516 2.282393 0.04665864 0.1812520 2.7821710 0.06530833 0.02000000 0.07270000 0.052700000 7.962401e-06 7.962401e-06 FALSE TRUE
MSTRG.9115.5 ENSG00000130177 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC16 protein_coding   22.79176 16.01125 31.53276 1.174655 0.8227538 0.9773226 3.906048 1.5075571 7.175722 0.75942985 0.9302422 2.2433824 0.16086667 0.10133333 0.22670000 0.125366667 6.187951e-01 7.962401e-06 FALSE TRUE
MSTRG.9115.7 ENSG00000130177 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC16 protein_coding   22.79176 16.01125 31.53276 1.174655 0.8227538 0.9773226 1.279647 1.3326721 1.702615 0.07881872 0.4570495 0.3510937 0.05880833 0.08350000 0.05346667 -0.030033333 3.156658e-01 7.962401e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130177 E001 0.0000000       13 114234887 114234896 10 +      
ENSG00000130177 E002 0.4502799 0.0294206576 1.821708e-01 3.039260e-01 13 114234897 114234933 37 + 0.250 0.000 -10.181
ENSG00000130177 E003 1.2973666 0.0105807324 4.083872e-01 5.519800e-01 13 114234934 114234954 21 + 0.408 0.259 -0.930
ENSG00000130177 E004 4.7857251 0.0890098181 4.003109e-02 9.109196e-02 13 114234955 114234978 24 + 0.889 0.486 -1.710
ENSG00000130177 E005 11.7379373 0.0435001776 3.926302e-02 8.964907e-02 13 114234979 114235017 39 + 1.206 0.903 -1.106
ENSG00000130177 E006 27.9252692 0.0142115540 1.609203e-03 5.990661e-03 13 114235018 114235060 43 + 1.560 1.270 -1.003
ENSG00000130177 E007 33.6893380 0.0183966388 8.449305e-02 1.665896e-01 13 114235061 114235080 20 + 1.598 1.436 -0.556
ENSG00000130177 E008 54.5465419 0.0092896160 1.214138e-02 3.387103e-02 13 114235081 114235132 52 + 1.808 1.634 -0.587
ENSG00000130177 E009 54.6895633 0.0046099546 2.515043e-01 3.877533e-01 13 114236645 114236699 55 + 1.770 1.703 -0.227
ENSG00000130177 E010 43.4619146 0.0038193469 2.056719e-01 3.332671e-01 13 114236799 114236801 3 + 1.676 1.600 -0.260
ENSG00000130177 E011 103.9484629 0.0003121320 9.576318e-04 3.813678e-03 13 114236802 114236896 95 + 2.064 1.950 -0.383
ENSG00000130177 E012 77.0990271 0.0003405136 1.192756e-01 2.189066e-01 13 114238990 114239028 39 + 1.915 1.855 -0.202
ENSG00000130177 E013 0.3686942 0.0311054228 7.427495e-01 8.315702e-01 13 114239310 114239349 40 + 0.100 0.149 0.657
ENSG00000130177 E014 136.8934840 0.0006318740 5.648844e-03 1.768341e-02 13 114239350 114239490 141 + 2.171 2.084 -0.289
ENSG00000130177 E015 162.8417293 0.0004457169 5.182145e-05 2.908089e-04 13 114242121 114242280 160 + 2.257 2.142 -0.387
ENSG00000130177 E016 19.0621722 0.0022698593 5.088274e-06 3.615476e-05 13 114242281 114242675 395 + 1.430 1.033 -1.406
ENSG00000130177 E017 134.1611207 0.0050490655 9.129023e-02 1.771395e-01 13 114243257 114243348 92 + 2.161 2.080 -0.271
ENSG00000130177 E018 154.1580935 0.0014548338 1.499053e-02 4.046689e-02 13 114243856 114243989 134 + 2.221 2.140 -0.270
ENSG00000130177 E019 3.2320175 0.0082087794 1.465331e-02 3.971253e-02 13 114244562 114244889 328 + 0.754 0.347 -1.932
ENSG00000130177 E020 122.8756210 0.0012987921 9.203045e-02 1.782800e-01 13 114244890 114244969 80 + 2.115 2.057 -0.197
ENSG00000130177 E021 0.7770552 0.0147003686 3.541300e-01 4.984054e-01 13 114245743 114245999 257 + 0.182 0.347 1.236
ENSG00000130177 E022 131.2214139 0.0002693871 1.070762e-01 2.012188e-01 13 114246000 114246049 50 + 2.138 2.091 -0.157
ENSG00000130177 E023 159.4023839 0.0002037989 2.763502e-01 4.158042e-01 13 114246931 114247004 74 + 2.215 2.189 -0.089
ENSG00000130177 E024 0.4418608 0.0263434802 1.819715e-01 3.036844e-01 13 114247005 114247237 233 + 0.250 0.000 -10.178
ENSG00000130177 E025 195.0252813 0.0002684580 8.407476e-01 9.006085e-01 13 114250549 114250674 126 + 2.287 2.297 0.031
ENSG00000130177 E026 188.3315715 0.0003008826 2.668463e-01 4.051036e-01 13 114257078 114257230 153 + 2.262 2.295 0.111
ENSG00000130177 E027 155.4387389 0.0003305068 5.616723e-01 6.894344e-01 13 114259335 114259398 64 + 2.197 2.184 -0.044
ENSG00000130177 E028 160.5408580 0.0002061431 5.855933e-01 7.092645e-01 13 114261887 114261948 62 + 2.199 2.219 0.064
ENSG00000130177 E029 247.7811123 0.0002327945 4.058484e-02 9.209354e-02 13 114262879 114263014 136 + 2.374 2.424 0.167
ENSG00000130177 E030 0.0000000       13 114264212 114264261 50 +      
ENSG00000130177 E031 1.6125878 0.1760074968 3.841305e-01 5.283026e-01 13 114264893 114265149 257 + 0.309 0.493 1.027
ENSG00000130177 E032 209.0546577 0.0002193207 1.462824e-02 3.965764e-02 13 114265150 114265240 91 + 2.294 2.357 0.213
ENSG00000130177 E033 3.7172026 0.0041488963 3.172065e-01 4.600590e-01 13 114269563 114269620 58 + 0.733 0.586 -0.627
ENSG00000130177 E034 203.9936931 0.0003354293 7.904937e-04 3.225429e-03 13 114272184 114272277 94 + 2.273 2.362 0.298
ENSG00000130177 E035 267.1779556 0.0035558947 1.798419e-05 1.127230e-04 13 114272278 114272481 204 + 2.355 2.509 0.511
ENSG00000130177 E036 91.1646781 0.0012126995 3.340325e-11 6.382397e-10 13 114272482 114272563 82 + 1.830 2.099 0.900
ENSG00000130177 E037 93.0272647 0.0036965705 9.325812e-06 6.241600e-05 13 114272564 114272723 160 + 1.870 2.082 0.711