ENSG00000130164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000535915 ENSG00000130164 HEK293_OSMI2_2hA HEK293_TMG_2hB LDLR protein_coding protein_coding 16.8906 17.31407 16.65899 0.9612899 0.1879016 -0.05561084 2.357258 0.06513598 3.006146 0.06513598 1.6515664 5.3270584 0.13515417 0.003866667 0.18240000 0.17853333 3.360286e-01 1.551093e-09 FALSE TRUE
ENST00000558013 ENSG00000130164 HEK293_OSMI2_2hA HEK293_TMG_2hB LDLR protein_coding protein_coding 16.8906 17.31407 16.65899 0.9612899 0.1879016 -0.05561084 1.105728 0.00000000 3.693499 0.00000000 1.3292375 8.5327450 0.06549583 0.000000000 0.22020000 0.22020000 1.551093e-09 1.551093e-09 FALSE TRUE
ENST00000558518 ENSG00000130164 HEK293_OSMI2_2hA HEK293_TMG_2hB LDLR protein_coding protein_coding 16.8906 17.31407 16.65899 0.9612899 0.1879016 -0.05561084 10.133737 13.22698631 7.056145 0.47764840 0.3223160 -0.9055794 0.60850000 0.767700000 0.42323333 -0.34446667 3.428801e-06 1.551093e-09 FALSE TRUE
ENST00000560628 ENSG00000130164 HEK293_OSMI2_2hA HEK293_TMG_2hB LDLR protein_coding processed_transcript 16.8906 17.31407 16.65899 0.9612899 0.1879016 -0.05561084 0.381657 0.88494254 0.000000 0.58352631 0.0000000 -6.4837232 0.02167083 0.053200000 0.00000000 -0.05320000 1.641542e-01 1.551093e-09   FALSE
MSTRG.16438.1 ENSG00000130164 HEK293_OSMI2_2hA HEK293_TMG_2hB LDLR protein_coding   16.8906 17.31407 16.65899 0.9612899 0.1879016 -0.05561084 1.387623 1.63490182 1.264256 0.71043615 0.2862058 -0.3683462 0.08115833 0.090633333 0.07586667 -0.01476667 9.957121e-01 1.551093e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130164 E001 6.3850071 0.0126609818 6.007485e-01 7.219294e-01 19 11089427 11089461 35 + 0.881 0.834 -0.180
ENSG00000130164 E002 6.3850071 0.0126609818 6.007485e-01 7.219294e-01 19 11089462 11089462 1 + 0.881 0.834 -0.180
ENSG00000130164 E003 13.4068299 0.0050415364 4.997262e-01 6.360063e-01 19 11089463 11089477 15 + 1.173 1.131 -0.147
ENSG00000130164 E004 72.1468368 0.0160316536 2.791613e-01 4.188747e-01 19 11089478 11089615 138 + 1.880 1.835 -0.152
ENSG00000130164 E005 0.1817044 0.0396621637 5.734772e-01   19 11090599 11090919 321 + 0.000 0.116 10.452
ENSG00000130164 E006 95.7616918 0.0160910866 4.451126e-02 9.930313e-02 19 11100223 11100345 123 + 2.037 1.927 -0.369
ENSG00000130164 E007 0.3634088 0.3423685587 3.425230e-01   19 11100346 11100578 233 + 0.000 0.208 10.458
ENSG00000130164 E008 80.3709552 0.0197232021 3.156271e-02 7.500013e-02 19 11102664 11102786 123 + 1.977 1.837 -0.472
ENSG00000130164 E009 3.4894357 0.0114247164 8.238021e-01 8.889810e-01 19 11102787 11104268 1482 + 0.615 0.669 0.231
ENSG00000130164 E010 75.3553110 0.0109801007 9.903133e-02 1.889877e-01 19 11105220 11105306 87 + 1.917 1.838 -0.265
ENSG00000130164 E011 147.0909534 0.0016345850 1.615550e-06 1.282361e-05 19 11105307 11105600 294 + 2.237 2.099 -0.463
ENSG00000130164 E012 1.4726265 0.0092195013 9.548048e-01 9.756759e-01 19 11106356 11106564 209 + 0.378 0.402 0.137
ENSG00000130164 E013 115.4620419 0.0004370806 3.045277e-06 2.275237e-05 19 11106565 11106687 123 + 2.129 1.997 -0.441
ENSG00000130164 E014 113.3349853 0.0025357637 3.788745e-04 1.692917e-03 19 11107392 11107514 123 + 2.117 1.999 -0.395
ENSG00000130164 E015 1.2793957 0.1744280751 3.953543e-01 5.391700e-01 19 11107515 11107515 1 + 0.436 0.284 -0.911
ENSG00000130164 E016 82.2646233 0.0003230694 4.116421e-03 1.346950e-02 19 11110652 11110712 61 + 1.960 1.873 -0.294
ENSG00000130164 E017 84.6723004 0.0003217227 1.225151e-03 4.725570e-03 19 11110713 11110771 59 + 1.979 1.880 -0.335
ENSG00000130164 E018 117.1768297 0.0003186381 2.089755e-05 1.290578e-04 19 11111514 11111639 126 + 2.128 2.013 -0.385
ENSG00000130164 E019 104.9954748 0.0002962880 1.810148e-03 6.631482e-03 19 11113278 11113370 93 + 2.065 1.982 -0.279
ENSG00000130164 E020 102.5430427 0.0002997771 2.056652e-02 5.268569e-02 19 11113371 11113449 79 + 2.041 1.985 -0.189
ENSG00000130164 E021 0.3289534 0.0294259144 8.937028e-01   19 11113450 11113473 24 + 0.129 0.116 -0.184
ENSG00000130164 E022 0.8396112 0.6113531061 9.456035e-01 9.698750e-01 19 11113474 11113534 61 + 0.229 0.285 0.420
ENSG00000130164 E023 187.0141025 0.0004138271 1.741438e-05 1.095028e-04 19 11113535 11113762 228 + 2.318 2.228 -0.300
ENSG00000130164 E024 135.9475051 0.0092894943 2.045636e-02 5.245174e-02 19 11116094 11116212 119 + 2.186 2.089 -0.326
ENSG00000130164 E025 138.9899678 0.0005821172 1.118751e-04 5.764359e-04 19 11116859 11116998 140 + 2.194 2.099 -0.320
ENSG00000130164 E026 133.3828535 0.0036529098 9.848514e-02 1.881904e-01 19 11120092 11120233 142 + 2.148 2.105 -0.144
ENSG00000130164 E027 143.2857412 0.0005730595 5.047636e-01 6.406490e-01 19 11120370 11120522 153 + 2.150 2.154 0.013
ENSG00000130164 E028 151.5873403 0.0002570066 6.546320e-01 7.647554e-01 19 11123174 11123344 171 + 2.167 2.179 0.038
ENSG00000130164 E029 1.5016946 0.1548549521 8.632527e-03 2.536733e-02 19 11127547 11127654 108 + 0.000 0.568 12.899
ENSG00000130164 E030 116.4958850 0.0003282126 1.002908e-01 1.909239e-01 19 11128008 11128085 78 + 2.077 2.046 -0.101
ENSG00000130164 E031 1.8454868 0.2213955378 9.935774e-01 1.000000e+00 19 11129451 11129512 62 + 0.436 0.485 0.245
ENSG00000130164 E032 160.0856283 0.0002419323 6.951792e-01 7.958231e-01 19 11129513 11129670 158 + 2.189 2.203 0.045
ENSG00000130164 E033 57.9824132 0.0005011470 4.506454e-01 5.917245e-01 19 11131281 11131286 6 + 1.725 1.784 0.202
ENSG00000130164 E034 614.1898812 0.0011580327 4.257652e-07 3.819126e-06 19 11131287 11132446 1160 + 2.705 2.830 0.416
ENSG00000130164 E035 165.5721679 0.0068802883 4.022592e-07 3.625270e-06 19 11132447 11132922 476 + 2.036 2.312 0.924
ENSG00000130164 E036 151.2286971 0.0043926259 2.028198e-11 4.015005e-10 19 11132923 11133094 172 + 1.963 2.284 1.075
ENSG00000130164 E037 272.1458525 0.0063033931 2.031588e-20 1.366270e-18 19 11133095 11133846 752 + 2.129 2.566 1.459