ENSG00000130158

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000294618	ENSG00000130158	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DOCK6	protein_coding	protein_coding	9.060392	13.21047	7.521628	0.7194322	0.7350137	-0.8117399	0.3501415	0.7336959	0.0000000	0.4231028	0.00000000	-6.2166408	0.03636667	0.05443333	0.00000000	-0.05443333	0.216337903	0.004697933	FALSE	TRUE
ENST00000586702	ENSG00000130158	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DOCK6	protein_coding	processed_transcript	9.060392	13.21047	7.521628	0.7194322	0.7350137	-0.8117399	2.0858884	4.6145588	0.8573829	0.6672038	0.28327506	-2.4145748	0.19741250	0.34830000	0.10823333	-0.24006667	0.004697933	0.004697933	FALSE	TRUE
ENST00000587656	ENSG00000130158	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DOCK6	protein_coding	protein_coding	9.060392	13.21047	7.521628	0.7194322	0.7350137	-0.8117399	2.2197842	3.6913138	1.5238182	0.2289377	0.10797236	-1.2709100	0.23627917	0.27923333	0.20753333	-0.07170000	0.233551644	0.004697933	FALSE	TRUE
ENST00000592550	ENSG00000130158	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DOCK6	protein_coding	retained_intron	9.060392	13.21047	7.521628	0.7194322	0.7350137	-0.8117399	0.5613407	0.2668888	0.1766216	0.2668888	0.17662164	-0.5691902	0.06952500	0.02053333	0.02123333	0.00070000	0.989213710	0.004697933		FALSE
MSTRG.16445.4	ENSG00000130158	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DOCK6	protein_coding		9.060392	13.21047	7.521628	0.7194322	0.7350137	-0.8117399	2.7862639	2.9495775	3.6807563	1.0764110	0.04453372	0.3185253	0.33206250	0.22543333	0.49926667	0.27383333	0.155931313	0.004697933	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
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width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000130158	E001	2.1013859	0.0071072410	1.014138e-01	1.926146e-01	19	11199295	11199302	8	-	0.259	0.556	1.676
ENSG00000130158	E002	1.9530928	0.0075086285	1.467537e-01	2.572644e-01	19	11199303	11199305	3	-	0.259	0.524	1.524
ENSG00000130158	E003	12.1439332	0.0141552525	2.605614e-02	6.406148e-02	19	11199306	11199350	45	-	0.899	1.171	0.996
ENSG00000130158	E004	43.2145208	0.0148754806	1.025291e-05	6.798682e-05	19	11199351	11199496	146	-	1.330	1.723	1.348
ENSG00000130158	E005	41.0851589	0.0034686044	7.742620e-09	9.743697e-08	19	11199497	11199539	43	-	1.295	1.705	1.408
ENSG00000130158	E006	92.8642817	0.0047377779	3.929920e-12	8.740450e-11	19	11200308	11200469	162	-	1.665	2.049	1.295
ENSG00000130158	E007	70.9951924	0.0004748073	1.659126e-12	3.919157e-11	19	11200716	11200822	107	-	1.576	1.924	1.180
ENSG00000130158	E008	101.3958489	0.0027065340	6.542036e-09	8.348731e-08	19	11200909	11201052	144	-	1.787	2.063	0.928
ENSG00000130158	E009	136.8303669	0.0141797427	2.646559e-02	6.487954e-02	19	11201889	11202081	193	-	2.006	2.164	0.530
ENSG00000130158	E010	75.9365675	0.0123044804	1.572709e-01	2.714662e-01	19	11202082	11202125	44	-	1.788	1.897	0.368
ENSG00000130158	E011	92.6494360	0.0020140095	7.876520e-03	2.346938e-02	19	11202394	11202483	90	-	1.856	1.983	0.425
ENSG00000130158	E012	5.3453042	0.0391208982	7.074272e-01	8.053504e-01	19	11202484	11202583	100	-	0.826	0.771	-0.217
ENSG00000130158	E013	98.8280371	0.0003380012	6.969187e-04	2.887849e-03	19	11202584	11202709	126	-	1.873	2.011	0.463
ENSG00000130158	E014	3.7934882	0.0044144168	6.249622e-03	1.926912e-02	19	11202710	11202715	6	-	0.876	0.489	-1.646
ENSG00000130158	E015	3.7976408	0.0256470540	1.133443e-02	3.196441e-02	19	11203282	11203313	32	-	0.876	0.489	-1.646
ENSG00000130158	E016	45.8258381	0.0100387641	1.825932e-01	3.044640e-01	19	11204081	11204095	15	-	1.566	1.677	0.377
ENSG00000130158	E017	77.1242263	0.0045941477	2.052605e-02	5.259628e-02	19	11204200	11204331	132	-	1.770	1.906	0.460
ENSG00000130158	E018	0.5911862	0.0183550231	1.159053e-02	3.256110e-02	19	11206181	11206387	207	-	0.420	0.000	-14.841
ENSG00000130158	E019	63.5659899	0.0003914044	1.230172e-01	2.242614e-01	19	11208686	11208829	144	-	1.729	1.808	0.268
ENSG00000130158	E020	65.6852055	0.0003675933	9.933746e-01	1.000000e+00	19	11208911	11209103	193	-	1.793	1.801	0.026
ENSG00000130158	E021	48.9168274	0.0013827902	7.431809e-01	8.319058e-01	19	11211776	11211876	101	-	1.657	1.682	0.086
ENSG00000130158	E022	69.1157471	0.0018628840	8.460038e-01	9.042608e-01	19	11211993	11212151	159	-	1.823	1.822	-0.004
ENSG00000130158	E023	71.8475097	0.0004466860	6.341425e-01	7.487000e-01	19	11213176	11213328	153	-	1.815	1.843	0.095
ENSG00000130158	E024	63.8817622	0.0003826812	7.972889e-01	8.706659e-01	19	11214275	11214409	135	-	1.772	1.792	0.065
ENSG00000130158	E025	69.5781106	0.0057529734	9.607873e-01	9.793136e-01	19	11214553	11214649	97	-	1.818	1.830	0.039
ENSG00000130158	E026	62.1261770	0.0064878531	7.066678e-01	8.047857e-01	19	11215387	11215471	85	-	1.787	1.773	-0.047
ENSG00000130158	E027	0.1515154	0.0426850386	3.128771e-01		19	11215611	11215800	190	-	0.148	0.000	-12.841
ENSG00000130158	E028	61.3808041	0.0020626302	9.807670e-01	9.919618e-01	19	11215801	11215927	127	-	1.766	1.773	0.024
ENSG00000130158	E029	0.1451727	0.0432661463	3.128552e-01		19	11216676	11216913	238	-	0.148	0.000	-12.840
ENSG00000130158	E030	59.2399973	0.0005413236	9.373598e-01	9.646317e-01	19	11216914	11217096	183	-	1.748	1.752	0.013
ENSG00000130158	E031	58.1228665	0.0005091202	4.178752e-01	5.611887e-01	19	11217231	11217391	161	-	1.760	1.729	-0.105
ENSG00000130158	E032	47.8092190	0.0004983212	2.798926e-02	6.799011e-02	19	11221851	11221985	135	-	1.725	1.619	-0.360
ENSG00000130158	E033	27.1947722	0.0014829948	8.162766e-02	1.621027e-01	19	11221986	11222020	35	-	1.499	1.388	-0.384
ENSG00000130158	E034	49.8091662	0.0005576110	6.926514e-02	1.421477e-01	19	11222109	11222248	140	-	1.735	1.650	-0.287
ENSG00000130158	E035	1.3274538	0.0099468612	9.502146e-01	9.728445e-01	19	11222249	11222324	76	-	0.347	0.362	0.090
ENSG00000130158	E036	52.4990103	0.0004502347	9.501836e-03	2.754223e-02	19	11222735	11222905	171	-	1.775	1.656	-0.406
ENSG00000130158	E037	32.9715114	0.0006288070	4.521299e-02	1.005820e-01	19	11222993	11223106	114	-	1.576	1.460	-0.396
ENSG00000130158	E038	42.8322524	0.0028097087	1.542951e-01	2.674898e-01	19	11227337	11227477	141	-	1.657	1.582	-0.256
ENSG00000130158	E039	0.4804688	0.0209747692	3.321073e-01	4.757409e-01	19	11228840	11228939	100	-	0.259	0.100	-1.646
ENSG00000130158	E040	27.7322137	0.0023795232	1.068795e-01	2.009388e-01	19	11228940	11229000	61	-	1.493	1.389	-0.360
ENSG00000130158	E041	22.1652765	0.0024684612	1.087794e-01	2.037363e-01	19	11229001	11229035	35	-	1.405	1.290	-0.400
ENSG00000130158	E042	7.9608822	0.0021184924	2.549646e-01	3.917396e-01	19	11229298	11229390	93	-	0.826	0.970	0.547
ENSG00000130158	E043	30.3295138	0.0051603180	4.441853e-02	9.914646e-02	19	11232185	11232289	105	-	1.551	1.417	-0.463
ENSG00000130158	E044	50.3179058	0.0004722596	8.845082e-03	2.589474e-02	19	11233203	11233366	164	-	1.763	1.640	-0.418
ENSG00000130158	E045	47.3603722	0.0006396442	6.470237e-01	7.587821e-01	19	11235598	11235759	162	-	1.672	1.655	-0.057
ENSG00000130158	E046	0.2955422	0.0301004399	7.350230e-01		19	11235899	11236345	447	-	0.148	0.100	-0.649
ENSG00000130158	E047	50.5615447	0.0004562959	3.224191e-02	7.631637e-02	19	11236346	11236577	232	-	1.748	1.648	-0.339
ENSG00000130158	E048	0.0000000				19	11236578	11236792	215	-
ENSG00000130158	E049	24.5648116	0.0013661632	4.041023e-01	5.478105e-01	19	11236793	11236879	87	-	1.412	1.359	-0.183
ENSG00000130158	E050	3.2086291	0.0048862054	7.568519e-01	8.418763e-01	19	11236880	11237455	576	-	0.629	0.587	-0.186
ENSG00000130158	E051	28.8092744	0.0061367124	3.989621e-01	5.427181e-01	19	11237456	11237557	102	-	1.476	1.422	-0.184
ENSG00000130158	E052	0.6621601	0.0164619671	6.468798e-01	7.586744e-01	19	11237558	11237640	83	-	0.259	0.182	-0.646
ENSG00000130158	E053	35.6229029	0.0237222987	4.435531e-01	5.851291e-01	19	11237641	11237779	139	-	1.567	1.517	-0.170
ENSG00000130158	E054	2.1475764	0.0108319388	3.604472e-04	1.620639e-03	19	11237780	11238044	265	-	0.770	0.182	-3.231
ENSG00000130158	E055	30.6823492	0.0187133287	2.275818e-02	5.724602e-02	19	11238045	11238115	71	-	1.590	1.395	-0.672
ENSG00000130158	E056	0.1817044	0.0395813264	7.402631e-01		19	11238116	11238186	71	-	0.000	0.100	11.274
ENSG00000130158	E057	40.7573645	0.0032701608	2.830697e-02	6.861916e-02	19	11238187	11238304	118	-	1.668	1.544	-0.425
ENSG00000130158	E058	0.0000000				19	11238305	11238921	617	-
ENSG00000130158	E059	45.2864857	0.0005614075	2.158038e-02	5.480933e-02	19	11242045	11242207	163	-	1.708	1.594	-0.388
ENSG00000130158	E060	28.6098676	0.0159874345	7.916792e-02	1.581814e-01	19	11243059	11243152	94	-	1.526	1.387	-0.478
ENSG00000130158	E061	25.6754456	0.0151108479	9.484606e-03	2.749885e-02	19	11243258	11243385	128	-	1.531	1.311	-0.761
ENSG00000130158	E062	33.2032230	0.0118945116	1.993760e-03	7.207140e-03	19	11243557	11243710	154	-	1.645	1.414	-0.791
ENSG00000130158	E063	32.3864612	0.0006393684	1.391117e-03	5.277617e-03	19	11243802	11243882	81	-	1.612	1.423	-0.646
ENSG00000130158	E064	42.7441659	0.0005580397	9.303894e-04	3.720674e-03	19	11245563	11245712	150	-	1.722	1.551	-0.580
ENSG00000130158	E065	25.6493424	0.0010787351	5.102474e-02	1.109916e-01	19	11245812	11245878	67	-	1.482	1.354	-0.441
ENSG00000130158	E066	0.1817044	0.0395813264	7.402631e-01		19	11247258	11248065	808	-	0.000	0.100	11.274
ENSG00000130158	E067	29.8020322	0.0128467184	4.612943e-02	1.022772e-01	19	11248066	11248151	86	-	1.556	1.402	-0.532
ENSG00000130158	E068	39.1266258	0.0108715818	7.266762e-02	1.477839e-01	19	11250874	11251086	213	-	1.649	1.528	-0.412
ENSG00000130158	E069	1.8800570	0.1051527830	4.979540e-01	6.344766e-01	19	11251087	11252118	1032	-	0.537	0.405	-0.665
ENSG00000130158	E070	30.7312135	0.0274389688	2.266157e-01	3.583522e-01	19	11252119	11252248	130	-	1.531	1.437	-0.323
ENSG00000130158	E071	1.9071996	0.0885456509	3.571577e-01	5.015637e-01	19	11252249	11252403	155	-	0.537	0.367	-0.880
ENSG00000130158	E072	1.9617168	0.0079926364	5.292897e-02	1.143500e-01	19	11252404	11252481	78	-	0.629	0.310	-1.645
ENSG00000130158	E073	27.1949552	0.0013158613	7.798372e-02	1.562322e-01	19	11252482	11252550	69	-	1.487	1.374	-0.391
ENSG00000130158	E074	7.5820424	0.0030374707	2.804673e-03	9.688797e-03	19	11252551	11252782	232	-	1.108	0.774	-1.258
ENSG00000130158	E075	29.7688831	0.0008751853	4.640713e-05	2.635241e-04	19	11252783	11252881	99	-	1.607	1.354	-0.870
ENSG00000130158	E076	20.7954896	0.0008780205	6.820531e-05	3.715043e-04	19	11252882	11252958	77	-	1.482	1.192	-1.009
ENSG00000130158	E077	13.9604035	0.0016363621	3.301384e-04	1.501362e-03	19	11253639	11253726	88	-	1.330	1.016	-1.120
ENSG00000130158	E078	0.2214452	0.0371998204	7.399565e-01		19	11253727	11254048	322	-	0.000	0.101	11.277
ENSG00000130158	E079	7.1495593	0.0022752001	3.175523e-06	2.362339e-05	19	11262397	11262524	128	-	1.159	0.615	-2.105

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000130158

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3