ENSG00000130150

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380492 ENSG00000130150 HEK293_OSMI2_2hA HEK293_TMG_2hB MOSPD2 protein_coding protein_coding 4.065538 1.001094 6.168713 0.1271153 0.3211177 2.611389 3.0775143 0.8082132 4.6473435 0.09160238 0.0854808 2.508959 0.77595417 0.8237000 0.75720000 -0.06650000 0.77723923 0.03340325 FALSE  
ENST00000461777 ENSG00000130150 HEK293_OSMI2_2hA HEK293_TMG_2hB MOSPD2 protein_coding retained_intron 4.065538 1.001094 6.168713 0.1271153 0.3211177 2.611389 0.3676211 0.0000000 0.4269248 0.00000000 0.1125710 5.449313 0.05884167 0.0000000 0.06966667 0.06966667 0.03340325 0.03340325 FALSE  
ENST00000482354 ENSG00000130150 HEK293_OSMI2_2hA HEK293_TMG_2hB MOSPD2 protein_coding protein_coding 4.065538 1.001094 6.168713 0.1271153 0.3211177 2.611389 0.1789537 0.1718148 0.5442393 0.08939913 0.1230041 1.608039 0.05531667 0.1560667 0.08726667 -0.06880000 0.69849291 0.03340325 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130150 E001 4.7477233 0.0129582487 6.884359e-01 0.7905664691 X 14873421 14873454 34 + 0.671 0.613 -0.249
ENSG00000130150 E002 12.6846973 0.0014256729 5.398124e-01 0.6710401114 X 14873455 14873490 36 + 1.012 1.101 0.325
ENSG00000130150 E003 17.9710522 0.0010392834 6.533638e-01 0.7638671944 X 14873491 14873528 38 + 1.154 1.218 0.228
ENSG00000130150 E004 17.1476954 0.0015197443 2.331164e-01 0.3661167390 X 14873529 14873537 9 + 1.119 1.257 0.489
ENSG00000130150 E005 26.9018103 0.0046048590 3.559827e-01 0.5003586947 X 14873689 14873758 70 + 1.312 1.412 0.345
ENSG00000130150 E006 0.9694574 0.0153037373 2.869046e-01 0.4273536197 X 14873759 14874454 696 + 0.189 0.407 1.505
ENSG00000130150 E007 0.0000000       X 14885291 14885457 167 +      
ENSG00000130150 E008 31.5262642 0.0057008525 3.105395e-02 0.0740202307 X 14892723 14892878 156 + 1.422 1.238 -0.639
ENSG00000130150 E009 2.9772628 0.0146193437 1.918406e-02 0.0497379493 X 14892879 14893353 475 + 0.572 0.001 -9.940
ENSG00000130150 E010 25.9373174 0.0007809294 6.050340e-02 0.1274794585 X 14895308 14895394 87 + 1.335 1.175 -0.562
ENSG00000130150 E011 30.6351953 0.0033645515 1.583819e-01 0.2729660381 X 14897084 14897238 155 + 1.399 1.293 -0.368
ENSG00000130150 E012 16.5024671 0.0139010624 6.897135e-01 0.7915538089 X 14900575 14900635 61 + 1.133 1.103 -0.108
ENSG00000130150 E013 14.2775741 0.0167456398 3.482318e-01 0.4924566454 X 14902966 14903004 39 + 1.087 0.980 -0.389
ENSG00000130150 E014 19.0611131 0.0009979578 4.477335e-02 0.0997938304 X 14908860 14908921 62 + 1.219 1.013 -0.742
ENSG00000130150 E015 23.8050926 0.0008027609 2.349528e-01 0.3682925966 X 14908922 14908984 63 + 1.292 1.197 -0.333
ENSG00000130150 E016 34.5393138 0.0068044152 1.062501e-01 0.2000026169 X 14911237 14911413 177 + 1.454 1.327 -0.441
ENSG00000130150 E017 23.2375048 0.0091211334 9.501394e-02 0.1829068763 X 14912249 14912361 113 + 1.294 1.128 -0.588
ENSG00000130150 E018 20.9974841 0.0010783759 3.984705e-01 0.5422205906 X 14914503 14914599 97 + 1.240 1.175 -0.231
ENSG00000130150 E019 1.4737619 0.0087775403 6.135483e-01 0.7322186358 X 14915434 14915667 234 + 0.348 0.249 -0.665
ENSG00000130150 E020 15.7240872 0.0014514472 1.492650e-01 0.2606632071 X 14915668 14915764 97 + 1.132 0.979 -0.558
ENSG00000130150 E021 25.2336632 0.0008005175 1.298535e-01 0.2339548298 X 14916197 14916326 130 + 1.321 1.197 -0.436
ENSG00000130150 E022 22.0656221 0.0010895592 5.902008e-01 0.7131120983 X 14918680 14918782 103 + 1.250 1.218 -0.114
ENSG00000130150 E023 29.4711317 0.0240716131 1.625002e-02 0.0432746731 X 14919672 14920030 359 + 1.407 1.129 -0.979
ENSG00000130150 E024 99.6917423 0.0003838033 1.320440e-03 0.0050452452 X 14920031 14921379 1349 + 1.852 2.001 0.504
ENSG00000130150 E025 64.1128263 0.0190961782 4.521691e-06 0.0000325192 X 14921380 14922327 948 + 1.610 1.970 1.215