ENSG00000130119

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336470 ENSG00000130119 HEK293_OSMI2_2hA HEK293_TMG_2hB GNL3L protein_coding protein_coding 16.26975 15.1621 16.38369 0.3547871 0.5239059 0.1117197 7.357438 7.932452 6.8082842 0.1225515 0.05571843 -0.2201757 0.4579917 0.52350000 0.41653333 -0.1069667 0.013423097 4.193908e-09 FALSE TRUE
ENST00000360845 ENSG00000130119 HEK293_OSMI2_2hA HEK293_TMG_2hB GNL3L protein_coding protein_coding 16.26975 15.1621 16.38369 0.3547871 0.5239059 0.1117197 2.643836 4.745060 0.1769568 0.3519540 0.17695683 -4.6686865 0.1736000 0.31440000 0.01016667 -0.3042333 0.002723025 4.193908e-09 FALSE TRUE
MSTRG.34315.13 ENSG00000130119 HEK293_OSMI2_2hA HEK293_TMG_2hB GNL3L protein_coding   16.26975 15.1621 16.38369 0.3547871 0.5239059 0.1117197 4.154745 1.376171 6.7563734 0.7501055 0.18460802 2.2872772 0.2405625 0.08853333 0.41250000 0.3239667 0.236155567 4.193908e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000130119 E001 0.0000000       X 54530183 54530202 20 +      
ENSG00000130119 E002 0.0000000       X 54530203 54530203 1 +      
ENSG00000130119 E003 0.4375944 0.0255495108 4.591743e-02 1.018883e-01 X 54530204 54530208 5 + 0.301 0.000 -33.977
ENSG00000130119 E004 0.5891098 0.0182928118 1.700142e-02 4.493553e-02 X 54530209 54530210 2 + 0.368 0.000 -34.396
ENSG00000130119 E005 1.0632359 0.0114602099 1.786904e-02 4.685578e-02 X 54530211 54530218 8 + 0.477 0.120 -2.657
ENSG00000130119 E006 4.1278382 0.0038598239 1.665125e-01 2.836781e-01 X 54530219 54530237 19 + 0.754 0.653 -0.419
ENSG00000130119 E007 8.9793775 0.0208730686 9.838730e-03 2.836798e-02 X 54530238 54530247 10 + 1.103 0.885 -0.805
ENSG00000130119 E008 20.7579420 0.0266871062 7.455512e-04 3.062764e-03 X 54530248 54530259 12 + 1.452 1.200 -0.882
ENSG00000130119 E009 31.9255112 0.0006266014 6.766038e-07 5.827448e-06 X 54530260 54530278 19 + 1.606 1.416 -0.650
ENSG00000130119 E010 43.8924383 0.0005323222 1.527379e-08 1.819285e-07 X 54530279 54530302 24 + 1.738 1.555 -0.621
ENSG00000130119 E011 19.4075932 0.0011123168 8.466202e-03 2.495211e-02 X 54530303 54530312 10 + 1.356 1.266 -0.313
ENSG00000130119 E012 41.3035916 0.0096438177 1.008821e-01 1.918106e-01 X 54530313 54530419 107 + 1.623 1.618 -0.018
ENSG00000130119 E013 1.2147488 0.0113605867 9.655534e-01 9.823540e-01 X 54532447 54532519 73 + 0.301 0.356 0.345
ENSG00000130119 E014 58.7352169 0.0005551092 2.876414e-06 2.160784e-05 X 54532520 54532523 4 + 1.822 1.722 -0.337
ENSG00000130119 E015 79.0507029 0.0018137286 8.666785e-07 7.295372e-06 X 54532524 54532585 62 + 1.950 1.851 -0.333
ENSG00000130119 E016 80.3120338 0.0004404739 5.302430e-04 2.272640e-03 X 54539040 54539101 62 + 1.914 1.893 -0.071
ENSG00000130119 E017 0.4804688 0.0222400708 3.967575e-01 5.405264e-01 X 54539102 54539500 399 + 0.222 0.120 -1.072
ENSG00000130119 E018 102.7448431 0.0013424364 1.408726e-03 5.335869e-03 X 54540135 54540238 104 + 2.013 2.008 -0.018
ENSG00000130119 E019 47.9406063 0.0005002411 6.884644e-05 3.745011e-04 X 54540239 54540242 4 + 1.730 1.645 -0.288
ENSG00000130119 E020 108.5863334 0.0037131020 5.946907e-04 2.513831e-03 X 54541273 54541389 117 + 2.055 2.020 -0.116
ENSG00000130119 E021 96.3631903 0.0094058929 2.823806e-02 6.848385e-02 X 54542955 54543038 84 + 1.991 1.980 -0.037
ENSG00000130119 E022 0.3666179 0.0306178592 8.164948e-01 8.838898e-01 X 54543146 54543206 61 + 0.125 0.120 -0.069
ENSG00000130119 E023 117.7332152 0.0058158935 3.576966e-03 1.194692e-02 X 54543207 54543342 136 + 2.083 2.060 -0.078
ENSG00000130119 E024 0.0000000       X 54544006 54544120 115 +      
ENSG00000130119 E025 111.1908857 0.0002748644 6.206067e-07 5.389259e-06 X 54544223 54544326 104 + 2.074 2.024 -0.165
ENSG00000130119 E026 110.7938005 0.0026842454 8.088530e-04 3.290005e-03 X 54548229 54548373 145 + 2.056 2.035 -0.070
ENSG00000130119 E027 8.0479544 0.0030473279 3.287945e-05 1.936911e-04 X 54548374 54550026 1653 + 1.125 0.760 -1.376
ENSG00000130119 E028 3.4458843 0.0091590459 1.160340e-01 2.142944e-01 X 54550366 54550616 251 + 0.727 0.586 -0.605
ENSG00000130119 E029 73.9868696 0.0031484626 5.302982e-04 2.272774e-03 X 54550963 54551050 88 + 1.896 1.844 -0.175
ENSG00000130119 E030 107.5962289 0.0116491484 1.012184e-02 2.906219e-02 X 54551568 54551742 175 + 2.049 2.012 -0.126
ENSG00000130119 E031 120.1410267 0.0084098224 2.362958e-02 5.904731e-02 X 54551832 54551974 143 + 2.078 2.075 -0.012
ENSG00000130119 E032 151.3126024 0.0043913521 4.150012e-03 1.356348e-02 X 54552292 54552428 137 + 2.178 2.175 -0.008
ENSG00000130119 E033 147.7233700 0.0057393796 2.551710e-02 6.294450e-02 X 54554565 54554692 128 + 2.157 2.173 0.055
ENSG00000130119 E034 182.7827784 0.0015462276 6.755905e-02 1.392952e-01 X 54558436 54558655 220 + 2.224 2.284 0.200
ENSG00000130119 E035 135.1103056 0.0034715675 7.094287e-01 8.068145e-01 X 54560520 54560647 128 + 2.050 2.183 0.446
ENSG00000130119 E036 93.4099064 0.0004780285 7.282640e-01 8.207559e-01 X 54560648 54560809 162 + 1.893 2.023 0.439
ENSG00000130119 E037 1874.3742651 0.0085404932 9.197579e-10 1.372876e-08 X 54560810 54567289 6480 + 3.091 3.372 0.936
ENSG00000130119 E038 3.1726499 0.4540245292 5.706413e-01 6.970677e-01 X 54576501 54576614 114 + 0.367 0.766 1.862
ENSG00000130119 E039 0.3666179 0.0306178592 8.164948e-01 8.838898e-01 X 54587702 54587727 26 + 0.125 0.120 -0.069
ENSG00000130119 E040 11.2162942 0.0156542991 2.239827e-01 3.551728e-01 X 54620845 54621521 677 + 1.103 1.081 -0.080
ENSG00000130119 E041 1.3587781 0.0095682330 3.072533e-02 7.337753e-02 X 54636235 54636305 71 + 0.523 0.213 -1.880
ENSG00000130119 E042 1.0298247 0.0116552857 1.777172e-02 4.664838e-02 X 54636394 54636427 34 + 0.477 0.120 -2.658
ENSG00000130119 E043 0.6633060 0.0225354351 1.885137e-01 3.118634e-01 X 54636428 54636445 18 + 0.301 0.120 -1.655
ENSG00000130119 E044 1.1908034 0.0140895609 6.167069e-02 1.294379e-01 X 54642828 54642938 111 + 0.477 0.213 -1.660