ENSG00000129968

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292577 ENSG00000129968 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD17A protein_coding protein_coding 76.53788 131.1273 41.87131 12.53832 1.327785 -1.646699 61.72740 112.9781 32.950609 10.775939 0.7767979 -1.7773557 0.7762667 0.8616333 0.7873667 -0.07426667 0.0003199935 0.000186057 FALSE  
ENST00000588598 ENSG00000129968 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD17A protein_coding retained_intron 76.53788 131.1273 41.87131 12.53832 1.327785 -1.646699 12.70583 14.4000 7.732664 1.360981 0.5725181 -0.8961679 0.1950750 0.1102667 0.1843333 0.07406667 0.0001860570 0.000186057 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129968 E001 3.641956 7.409773e-03 5.979535e-02 1.262657e-01 19 1876708 1876809 102 - 0.799 0.501 -1.287
ENSG00000129968 E002 3.342159 4.877868e-03 4.422168e-01 5.838705e-01 19 1876810 1876975 166 - 0.656 0.524 -0.588
ENSG00000129968 E003 4.052301 4.125609e-03 6.234474e-02 1.305937e-01 19 1876976 1876976 1 - 0.338 0.680 1.686
ENSG00000129968 E004 4.052301 4.125609e-03 6.234474e-02 1.305937e-01 19 1876977 1876978 2 - 0.338 0.680 1.686
ENSG00000129968 E005 386.059064 8.050305e-04 1.628108e-04 8.039833e-04 19 1876979 1877203 225 - 2.410 2.505 0.315
ENSG00000129968 E006 732.683148 5.491426e-04 1.335704e-05 8.617821e-05 19 1877204 1877425 222 - 2.702 2.781 0.265
ENSG00000129968 E007 890.819960 1.028583e-04 3.165740e-12 7.162785e-11 19 1877508 1877647 140 - 2.770 2.868 0.326
ENSG00000129968 E008 449.063135 1.466743e-03 3.828493e-04 1.708309e-03 19 1877648 1877687 40 - 2.481 2.574 0.312
ENSG00000129968 E009 506.699740 2.864788e-03 8.718769e-04 3.515846e-03 19 1877688 1878663 976 - 2.687 2.586 -0.337
ENSG00000129968 E010 241.146465 3.631994e-03 7.934715e-04 3.236324e-03 19 1878664 1878904 241 - 2.389 2.258 -0.438
ENSG00000129968 E011 375.758172 9.466081e-04 6.915706e-09 8.781820e-08 19 1878905 1879920 1016 - 2.591 2.444 -0.491
ENSG00000129968 E012 1059.784178 8.427434e-05 1.029717e-02 2.949899e-02 19 1879921 1880061 141 - 2.903 2.931 0.092
ENSG00000129968 E013 779.817929 1.130142e-04 8.356904e-01 8.972459e-01 19 1880062 1880115 54 - 2.795 2.792 -0.008
ENSG00000129968 E014 13.881738 3.204742e-03 1.546696e-02 4.155267e-02 19 1880896 1881048 153 - 1.256 1.009 -0.888
ENSG00000129968 E015 555.309435 5.241028e-04 6.941702e-01 7.950550e-01 19 1881235 1881261 27 - 2.645 2.648 0.012
ENSG00000129968 E016 1322.154211 2.163671e-03 2.952481e-01 4.363799e-01 19 1881262 1881804 543 - 3.005 3.030 0.081
ENSG00000129968 E017 187.146315 9.685646e-04 3.480021e-61 3.724743e-58 19 1881805 1883800 1996 - 2.516 2.018 -1.662
ENSG00000129968 E018 22.832330 9.793205e-04 1.195463e-13 3.361189e-12 19 1884469 1884543 75 - 1.648 1.098 -1.914
ENSG00000129968 E019 72.168606 2.998750e-02 7.143637e-01 8.105971e-01 19 1885352 1885534 183 - 1.786 1.762 -0.079