ENSG00000129810

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263753 ENSG00000129810 HEK293_OSMI2_2hA HEK293_TMG_2hB SGO1 protein_coding protein_coding 14.04805 6.36584 21.10638 0.4954457 0.2184795 1.727675 1.3817955 0.4683500 2.797844 0.46835002 0.37385632 2.553324 0.10647500 0.08693333 0.13260000 0.04566667 2.853771e-01 8.966092e-17 FALSE TRUE
ENST00000306698 ENSG00000129810 HEK293_OSMI2_2hA HEK293_TMG_2hB SGO1 protein_coding protein_coding 14.04805 6.36584 21.10638 0.4954457 0.2184795 1.727675 0.4185524 0.9257484 0.000000 0.49620749 0.00000000 -6.548049 0.05927917 0.13450000 0.00000000 -0.13450000 5.486400e-02 8.966092e-17 FALSE TRUE
ENST00000412997 ENSG00000129810 HEK293_OSMI2_2hA HEK293_TMG_2hB SGO1 protein_coding protein_coding 14.04805 6.36584 21.10638 0.4954457 0.2184795 1.727675 3.5642662 1.9156148 4.888625 0.47646059 0.55581774 1.347058 0.27012500 0.29220000 0.23120000 -0.06100000 7.002132e-01 8.966092e-17 FALSE TRUE
ENST00000421451 ENSG00000129810 HEK293_OSMI2_2hA HEK293_TMG_2hB SGO1 protein_coding protein_coding 14.04805 6.36584 21.10638 0.4954457 0.2184795 1.727675 0.5935604 0.0000000 2.252366 0.00000000 0.03702568 7.821689 0.03132917 0.00000000 0.10673333 0.10673333 8.966092e-17 8.966092e-17 FALSE TRUE
ENST00000437051 ENSG00000129810 HEK293_OSMI2_2hA HEK293_TMG_2hB SGO1 protein_coding protein_coding 14.04805 6.36584 21.10638 0.4954457 0.2184795 1.727675 3.7239116 1.0695155 5.248676 0.28982159 0.34134639 2.284316 0.24063333 0.16790000 0.24843333 0.08053333 3.654528e-01 8.966092e-17 FALSE TRUE
ENST00000442720 ENSG00000129810 HEK293_OSMI2_2hA HEK293_TMG_2hB SGO1 protein_coding protein_coding 14.04805 6.36584 21.10638 0.4954457 0.2184795 1.727675 2.0718932 1.5130019 3.604690 0.21982639 0.02643407 1.246954 0.16350417 0.24430000 0.17083333 -0.07346667 4.670093e-01 8.966092e-17 FALSE TRUE
MSTRG.22574.12 ENSG00000129810 HEK293_OSMI2_2hA HEK293_TMG_2hB SGO1 protein_coding   14.04805 6.36584 21.10638 0.4954457 0.2184795 1.727675 0.9203207 0.1273595 1.722268 0.09646306 0.14542645 3.656634 0.05649583 0.02286667 0.08163333 0.05876667 1.366196e-01 8.966092e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129810 E001 0.0000000       3 20142027 20142161 135 -      
ENSG00000129810 E002 20.4233813 0.0071317792 5.135302e-06 3.645200e-05 3 20160593 20160945 353 - 1.141 1.532 1.364
ENSG00000129810 E003 17.1054595 0.0084776052 4.914049e-03 1.569135e-02 3 20160946 20161008 63 - 1.123 1.388 0.932
ENSG00000129810 E004 12.3780186 0.0214801626 9.269974e-02 1.793473e-01 3 20161009 20161039 31 - 1.023 1.224 0.722
ENSG00000129810 E005 14.5806849 0.0149203285 1.179577e-02 3.304506e-02 3 20161040 20161108 69 - 1.061 1.324 0.936
ENSG00000129810 E006 17.0624354 0.0112741803 2.668973e-03 9.279299e-03 3 20161109 20161226 118 - 1.116 1.405 1.015
ENSG00000129810 E007 3.5250028 0.0345835248 9.883414e-01 9.967767e-01 3 20169481 20169483 3 - 0.634 0.629 -0.022
ENSG00000129810 E008 85.3292417 0.0004635671 7.367009e-05 3.977712e-04 3 20169484 20170060 577 - 1.848 2.009 0.541
ENSG00000129810 E009 77.2699951 0.0003483937 1.894519e-09 2.664917e-08 3 20170061 20170478 418 - 1.768 2.016 0.835
ENSG00000129810 E010 11.1733999 0.0431695406 2.466232e-01 3.819937e-01 3 20170479 20170484 6 - 0.997 1.174 0.638
ENSG00000129810 E011 62.2322224 0.0031490364 1.478030e-01 2.586969e-01 3 20170485 20170643 159 - 1.738 1.821 0.279
ENSG00000129810 E012 50.3327360 0.0143549954 7.329143e-01 8.242674e-01 3 20170644 20170723 80 - 1.663 1.701 0.130
ENSG00000129810 E013 62.1075764 0.0086351372 3.254178e-02 7.688495e-02 3 20170724 20170815 92 - 1.715 1.849 0.455
ENSG00000129810 E014 130.9495646 0.0002718810 1.197046e-01 2.195534e-01 3 20171043 20171232 190 - 2.065 2.119 0.181
ENSG00000129810 E015 0.7427016 0.0156446629 1.669406e-01 2.842234e-01 3 20171233 20171267 35 - 0.295 0.001 -9.262
ENSG00000129810 E016 132.8777669 0.0005273822 1.918971e-06 1.498283e-05 3 20174249 20174721 473 - 2.134 1.966 -0.563
ENSG00000129810 E017 66.7079081 0.0034954963 1.050458e-05 6.949993e-05 3 20174722 20174878 157 - 1.856 1.598 -0.874
ENSG00000129810 E018 52.6047577 0.0011646062 2.055155e-06 1.594426e-05 3 20174879 20175004 126 - 1.759 1.475 -0.968
ENSG00000129810 E019 57.3541703 0.0004081266 4.149035e-04 1.831536e-03 3 20175005 20175055 51 - 1.779 1.592 -0.636
ENSG00000129810 E020 90.4276820 0.0016624194 3.628854e-02 8.413705e-02 3 20176601 20176659 59 - 1.951 1.859 -0.310
ENSG00000129810 E021 115.0326305 0.0015599158 8.002568e-02 1.595994e-01 3 20178271 20178347 77 - 2.048 1.981 -0.227
ENSG00000129810 E022 132.5863646 0.0002569234 2.648419e-02 6.491927e-02 3 20183608 20183758 151 - 2.110 2.038 -0.240
ENSG00000129810 E023 80.9963813 0.0003446144 5.007282e-01 6.369533e-01 3 20183759 20183804 46 - 1.885 1.859 -0.087
ENSG00000129810 E024 109.9508794 0.0003305503 7.361949e-01 8.267480e-01 3 20183886 20184034 149 - 2.012 2.002 -0.032
ENSG00000129810 E025 26.6417543 0.0007113252 4.970505e-01 6.336152e-01 3 20185948 20185959 12 - 1.390 1.442 0.179
ENSG00000129810 E026 48.5662139 0.0004553486 8.299440e-01 8.932327e-01 3 20185960 20186058 99 - 1.662 1.654 -0.029
ENSG00000129810 E027 77.5175246 0.0058860826 9.279253e-01 9.586388e-01 3 20186059 20186326 268 - 1.856 1.865 0.031