ENSG00000129680

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316077 ENSG00000129680 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D3 protein_coding protein_coding 16.0915 8.48825 23.84854 0.1690598 0.4122664 1.489268 5.0634062 4.5777495 5.1683036 0.13397920 0.23764153 0.17469293 0.3715583 0.5402333 0.21653333 -0.32370000 5.862429e-16 2.475727e-37 FALSE TRUE
ENST00000370661 ENSG00000129680 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D3 protein_coding protein_coding 16.0915 8.48825 23.84854 0.1690598 0.4122664 1.489268 0.6681821 0.6194742 0.6260479 0.07862846 0.03542776 0.01498799 0.0514875 0.0727000 0.02623333 -0.04646667 6.195304e-04 2.475727e-37 FALSE TRUE
MSTRG.34954.2 ENSG00000129680 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D3 protein_coding   16.0915 8.48825 23.84854 0.1690598 0.4122664 1.489268 3.8468843 0.0000000 8.9439792 0.00000000 0.40978744 9.80638516 0.1765792 0.0000000 0.37580000 0.37580000 2.475727e-37 2.475727e-37 FALSE TRUE
MSTRG.34954.6 ENSG00000129680 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D3 protein_coding   16.0915 8.48825 23.84854 0.1690598 0.4122664 1.489268 5.8232781 2.7908908 8.2899940 0.25858544 0.63905079 1.56722457 0.3499500 0.3287000 0.34703333 0.01833333 8.974829e-01 2.475727e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129680 E001 33.3628595 0.0006463465 1.286065e-10 2.228086e-09 X 136213220 136214982 1763 - 1.323 1.732 1.401
ENSG00000129680 E002 3.9534216 0.0040319248 4.317883e-01 5.743041e-01 X 136214983 136215013 31 - 0.634 0.764 0.541
ENSG00000129680 E003 0.6997360 0.0166503527 5.369283e-03 1.693292e-02 X 136216814 136216819 6 - 0.000 0.466 12.096
ENSG00000129680 E004 74.4646477 0.0132129309 8.326923e-08 8.589766e-07 X 136216820 136217258 439 - 1.681 2.073 1.323
ENSG00000129680 E005 114.2604127 0.0003776760 5.704819e-19 3.233874e-17 X 136217259 136218130 872 - 1.901 2.219 1.065
ENSG00000129680 E006 178.1935458 0.0096407117 3.768823e-08 4.162734e-07 X 136218131 136218493 363 - 2.098 2.412 1.050
ENSG00000129680 E007 156.6420862 0.0084375754 1.439350e-04 7.206334e-04 X 136219398 136219495 98 - 2.091 2.310 0.732
ENSG00000129680 E008 122.4965195 0.0061819192 3.057972e-03 1.043638e-02 X 136219593 136219626 34 - 2.010 2.176 0.556
ENSG00000129680 E009 117.4482537 0.0042436989 5.310419e-02 1.146671e-01 X 136219627 136219671 45 - 2.017 2.122 0.352
ENSG00000129680 E010 199.5247372 0.0003450084 1.043049e-02 2.981823e-02 X 136220765 136220963 199 - 2.251 2.337 0.288
ENSG00000129680 E011 0.3729606 0.0320252090 5.881129e-01 7.113475e-01 X 136221779 136221877 99 - 0.086 0.171 1.130
ENSG00000129680 E012 120.2873101 0.0002618692 7.043105e-03 2.133507e-02 X 136222393 136222486 94 - 2.023 2.131 0.362
ENSG00000129680 E013 91.5628885 0.0006763365 1.224378e-01 2.234179e-01 X 136224827 136224880 54 - 1.915 1.994 0.266
ENSG00000129680 E014 125.1951667 0.0002461736 5.590445e-01 6.872185e-01 X 136225909 136226013 105 - 2.082 2.082 -0.001
ENSG00000129680 E015 143.0172450 0.0002294967 8.664828e-01 9.180536e-01 X 136227284 136227431 148 - 2.135 2.149 0.047
ENSG00000129680 E016 0.2924217 0.0272394520 4.899247e-01   X 136227432 136227433 2 - 0.158 0.000 -9.118
ENSG00000129680 E017 134.1700301 0.0002369817 6.865193e-01 7.890288e-01 X 136228623 136228758 136 - 2.110 2.117 0.021
ENSG00000129680 E018 1.0445865 0.0975995602 3.106959e-01 4.531244e-01 X 136228759 136228995 237 - 0.366 0.170 -1.469
ENSG00000129680 E019 151.2234733 0.0030989081 6.655157e-02 1.376419e-01 X 136230385 136230590 206 - 2.182 2.128 -0.182
ENSG00000129680 E020 54.6496995 0.0018041902 1.723828e-01 2.913056e-01 X 136230591 136230593 3 - 1.745 1.691 -0.183
ENSG00000129680 E021 112.1767586 0.0020227457 1.247966e-02 3.468711e-02 X 136230839 136230966 128 - 2.063 1.979 -0.280
ENSG00000129680 E022 0.6696487 0.0253475653 7.626765e-01 8.462435e-01 X 136230967 136231155 189 - 0.220 0.171 -0.456
ENSG00000129680 E023 225.2262080 0.0049042842 8.431060e-05 4.484485e-04 X 136231544 136232097 554 - 2.381 2.238 -0.476
ENSG00000129680 E024 97.2773688 0.0007591073 3.224314e-06 2.395908e-05 X 136232098 136232220 123 - 2.025 1.853 -0.577
ENSG00000129680 E025 97.8598654 0.0022434121 1.944715e-06 1.516820e-05 X 136236244 136236339 96 - 2.034 1.836 -0.667
ENSG00000129680 E026 104.3287505 0.0002997373 2.731524e-11 5.296613e-10 X 136240382 136240486 105 - 2.075 1.835 -0.807
ENSG00000129680 E027 110.3881361 0.0025002857 6.773121e-10 1.037138e-08 X 136241160 136241277 118 - 2.103 1.844 -0.871
ENSG00000129680 E028 113.4270032 0.0002925796 4.223906e-16 1.673950e-14 X 136244632 136244795 164 - 2.122 1.832 -0.976
ENSG00000129680 E029 78.5180424 0.0031860667 6.505343e-07 5.624140e-06 X 136246065 136246148 84 - 1.951 1.709 -0.816
ENSG00000129680 E030 70.0641614 0.0210264492 1.350623e-03 5.145212e-03 X 136246243 136246341 99 - 1.906 1.654 -0.851
ENSG00000129680 E031 49.4690040 0.0027847933 4.804036e-07 4.263613e-06 X 136251289 136251454 166 - 1.765 1.469 -1.010
ENSG00000129680 E032 0.0000000       X 136256304 136256482 179 -