ENSG00000129667

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000590168 ENSG00000129667 HEK293_OSMI2_2hA HEK293_TMG_2hB RHBDF2 protein_coding retained_intron 9.333695 10.98543 7.681741 1.057337 0.2787094 -0.5155212 1.1419813 1.8648534 0.6505540 0.1532478 0.04020194 -1.5050295 0.11842500 0.17173333 0.08510000 -0.08663333 0.007624245 0.007624245 TRUE  
ENST00000590288 ENSG00000129667 HEK293_OSMI2_2hA HEK293_TMG_2hB RHBDF2 protein_coding protein_coding 9.333695 10.98543 7.681741 1.057337 0.2787094 -0.5155212 0.5766926 0.5122732 0.9550190 0.2581233 0.17334430 0.8857527 0.06243750 0.04383333 0.12353333 0.07970000 0.411824330 0.007624245 TRUE  
ENST00000591697 ENSG00000129667 HEK293_OSMI2_2hA HEK293_TMG_2hB RHBDF2 protein_coding protein_coding 9.333695 10.98543 7.681741 1.057337 0.2787094 -0.5155212 0.4926696 0.2791739 0.5553436 0.2791739 0.27935063 0.9671906 0.05474583 0.02163333 0.07026667 0.04863333 0.553553436 0.007624245    
ENST00000675367 ENSG00000129667 HEK293_OSMI2_2hA HEK293_TMG_2hB RHBDF2 protein_coding protein_coding 9.333695 10.98543 7.681741 1.057337 0.2787094 -0.5155212 4.8717338 5.9270016 3.4508609 0.4922814 0.36922953 -0.7786036 0.51680833 0.54106667 0.44786667 -0.09320000 0.259908543 0.007624245 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129667 E001 0.1817044 0.0392013221 0.8383486791   17 76470891 76470895 5 - 0.000 0.096 8.906
ENSG00000129667 E002 43.1516988 0.0009809677 0.0077764814 0.023218406 17 76470896 76471068 173 - 1.493 1.661 0.573
ENSG00000129667 E003 155.6113018 0.0102514072 0.0021235598 0.007606679 17 76471069 76471617 549 - 2.032 2.216 0.616
ENSG00000129667 E004 83.2309980 0.0003307748 0.0080865033 0.023999934 17 76471618 76471812 195 - 1.805 1.926 0.406
ENSG00000129667 E005 28.0882695 0.0007676439 0.8084456707 0.878323075 17 76471813 76471813 1 - 1.435 1.429 -0.022
ENSG00000129667 E006 92.5768273 0.0046288959 0.0391143906 0.089397917 17 76471814 76472052 239 - 1.855 1.972 0.394
ENSG00000129667 E007 3.8988026 0.0040454418 0.3215645737 0.464822031 17 76472053 76472170 118 - 0.758 0.623 -0.565
ENSG00000129667 E008 61.8362125 0.0175521622 0.1590774536 0.273885766 17 76472686 76472839 154 - 1.672 1.804 0.448
ENSG00000129667 E009 7.1492594 0.0023184629 0.9873508777 0.996163741 17 76472840 76473004 165 - 0.872 0.884 0.043
ENSG00000129667 E010 52.8673721 0.0091983355 0.2781739144 0.417806709 17 76473005 76473105 101 - 1.631 1.723 0.313
ENSG00000129667 E011 43.9328342 0.0007304569 0.2961158195 0.437300762 17 76473252 76473327 76 - 1.565 1.635 0.239
ENSG00000129667 E012 50.1949280 0.0004690080 0.3498049032 0.494002871 17 76473648 76473742 95 - 1.631 1.691 0.203
ENSG00000129667 E013 39.7274205 0.0006780928 0.1658006507 0.282747645 17 76473839 76473902 64 - 1.511 1.604 0.318
ENSG00000129667 E014 50.8186797 0.0100302475 0.6417050756 0.754684463 17 76474033 76474142 110 - 1.695 1.677 -0.061
ENSG00000129667 E015 0.6192988 0.0201494956 0.1158557336 0.214029597 17 76474204 76474372 169 - 0.360 0.096 -2.390
ENSG00000129667 E016 59.4158292 0.0232499436 0.6244179846 0.740727075 17 76474373 76474534 162 - 1.710 1.769 0.200
ENSG00000129667 E017 2.1025318 0.0068127543 0.4263719132 0.569209035 17 76474660 76474729 70 - 0.360 0.507 0.780
ENSG00000129667 E018 43.3236105 0.0249119818 0.8026523119 0.874295364 17 76474730 76474804 75 - 1.593 1.626 0.112
ENSG00000129667 E019 39.0972156 0.0024966798 0.9532927180 0.974781455 17 76475030 76475141 112 - 1.560 1.574 0.050
ENSG00000129667 E020 1.4810575 0.0359891792 0.4029142593 0.546708568 17 76475792 76475922 131 - 0.270 0.434 0.994
ENSG00000129667 E021 5.1678400 0.0549682872 0.4296739136 0.572367818 17 76475923 76476829 907 - 0.846 0.731 -0.458
ENSG00000129667 E022 51.3867577 0.0140799710 0.6181425144 0.735856698 17 76476830 76477024 195 - 1.703 1.680 -0.078
ENSG00000129667 E023 44.0601938 0.0005267900 0.0302667449 0.072488894 17 76477180 76477287 108 - 1.688 1.582 -0.361
ENSG00000129667 E024 21.2200253 0.0073818648 0.0351566558 0.081945975 17 76477288 76477298 11 - 1.421 1.256 -0.577
ENSG00000129667 E025 0.5212538 0.0212989652 0.9496912751 0.972512018 17 76477646 76477656 11 - 0.155 0.174 0.195
ENSG00000129667 E026 37.8601635 0.0006837799 0.2519779412 0.388299880 17 76477657 76477785 129 - 1.594 1.538 -0.193
ENSG00000129667 E027 46.9478397 0.0004836948 0.4287443167 0.571471059 17 76478806 76479009 204 - 1.668 1.637 -0.107
ENSG00000129667 E028 0.9048261 0.4508048623 0.0256822119 0.063282582 17 76479010 76479081 72 - 0.557 0.000 -15.056
ENSG00000129667 E029 29.7144069 0.0008067424 0.7123985306 0.809152394 17 76479082 76479145 64 - 1.428 1.464 0.121
ENSG00000129667 E030 23.2270296 0.0008027394 0.3044476218 0.446452009 17 76479146 76479211 66 - 1.290 1.378 0.308
ENSG00000129667 E031 24.0182345 0.0009149463 0.7981542085 0.871180041 17 76479212 76479277 66 - 1.369 1.360 -0.029
ENSG00000129667 E032 13.5926949 0.0161403508 0.5064814562 0.642141774 17 76479733 76479735 3 - 1.169 1.110 -0.212
ENSG00000129667 E033 23.2678590 0.0019891787 0.9239083356 0.956090372 17 76479736 76479782 47 - 1.352 1.356 0.011
ENSG00000129667 E034 15.8918071 0.0020226180 0.2503381055 0.386338890 17 76479783 76479785 3 - 1.260 1.170 -0.320
ENSG00000129667 E035 32.4902464 0.0008096791 0.1394152896 0.247236758 17 76479786 76479854 69 - 1.549 1.467 -0.282
ENSG00000129667 E036 0.8868421 0.0733776401 0.0248966477 0.061660481 17 76479855 76479941 87 - 0.498 0.095 -3.133
ENSG00000129667 E037 24.7836256 0.0113790025 0.2812931399 0.421189361 17 76481375 76481382 8 - 1.435 1.352 -0.290
ENSG00000129667 E038 24.0441463 0.0091901873 0.4085438414 0.552156301 17 76481383 76481383 1 - 1.407 1.347 -0.209
ENSG00000129667 E039 37.2839027 0.0040876518 0.1451121080 0.254995395 17 76481384 76481438 55 - 1.604 1.520 -0.287
ENSG00000129667 E040 24.6972404 0.0070191194 0.0546719139 0.117423192 17 76481439 76481445 7 - 1.468 1.327 -0.489
ENSG00000129667 E041 30.0995520 0.0140174697 0.0731026371 0.148491667 17 76481446 76481484 39 - 1.550 1.411 -0.476
ENSG00000129667 E042 34.9364908 0.0054768692 0.0013183921 0.005038641 17 76481485 76481545 61 - 1.648 1.443 -0.701
ENSG00000129667 E043 1.4705356 0.0158429165 0.5158464146 0.650458635 17 76481546 76481894 349 - 0.270 0.395 0.784
ENSG00000129667 E044 0.5880631 0.2048668731 0.9964238705 1.000000000 17 76487411 76487711 301 - 0.155 0.178 0.235
ENSG00000129667 E045 47.7952004 0.0012126819 0.0002523627 0.001185160 17 76487712 76487851 140 - 1.765 1.583 -0.619
ENSG00000129667 E046 22.5017043 0.0010540952 0.0304939934 0.072937259 17 76487852 76487909 58 - 1.428 1.278 -0.521
ENSG00000129667 E047 2.4346944 0.0060512715 0.9927655755 0.999566641 17 76487910 76487973 64 - 0.498 0.507 0.044
ENSG00000129667 E048 4.7030240 0.0037845038 0.7864996019 0.863280854 17 76487974 76488014 41 - 0.688 0.735 0.196
ENSG00000129667 E049 9.3217080 0.0018961738 0.5057861361 0.641526400 17 76488015 76488132 118 - 0.920 1.005 0.317
ENSG00000129667 E050 0.5931727 0.8180549870 0.4830658703 0.621146971 17 76488133 76488178 46 - 0.000 0.278 12.261
ENSG00000129667 E051 3.9365649 0.0048941871 0.6948236829 0.795552388 17 76493062 76493202 141 - 0.603 0.672 0.297
ENSG00000129667 E052 13.5402091 0.0121032143 0.0104198896 0.029796930 17 76500936 76501352 417 - 1.280 1.028 -0.901
ENSG00000129667 E053 17.0131330 0.0011275107 0.0039239404 0.012928775 17 76501353 76501423 71 - 1.361 1.132 -0.804
ENSG00000129667 E054 0.0000000       17 76501459 76501790 332 -