ENSG00000129636

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320640 ENSG00000129636 HEK293_OSMI2_2hA HEK293_TMG_2hB ITFG1 protein_coding protein_coding 19.93894 7.627106 31.80891 0.8991622 0.9000527 2.058786 4.9767565 2.0774866 8.595268 0.1097744 0.2537507 2.043453 0.25259583 0.2823000 0.2709000 -0.0114000 0.99747074 0.04069257 FALSE TRUE
ENST00000542691 ENSG00000129636 HEK293_OSMI2_2hA HEK293_TMG_2hB ITFG1 protein_coding processed_transcript 19.93894 7.627106 31.80891 0.8991622 0.9000527 2.058786 0.1613586 0.8464453 0.000000 0.4245741 0.0000000 -6.420289 0.02113333 0.1035667 0.0000000 -0.1035667 0.04069257 0.04069257 FALSE TRUE
MSTRG.12573.5 ENSG00000129636 HEK293_OSMI2_2hA HEK293_TMG_2hB ITFG1 protein_coding   19.93894 7.627106 31.80891 0.8991622 0.9000527 2.058786 12.9709047 3.8708700 20.399919 0.8243652 1.3617780 2.394818 0.61927500 0.5051667 0.6400667 0.1349000 0.41495211 0.04069257 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129636 E001 0.0000000       16 47154387 47154390 4 -      
ENSG00000129636 E002 44.3442365 0.0169072076 3.706893e-01 0.5150986553 16 47154391 47155300 910 - 1.621 1.540 -0.279
ENSG00000129636 E003 39.4170159 0.0005518278 6.785886e-02 0.1398159448 16 47155301 47155556 256 - 1.521 1.633 0.381
ENSG00000129636 E004 19.2327356 0.0013660316 3.565463e-05 0.0002080150 16 47155557 47155584 28 - 1.138 1.473 1.175
ENSG00000129636 E005 15.5002472 0.0012209373 1.599303e-04 0.0007915334 16 47155585 47155604 20 - 1.051 1.387 1.187
ENSG00000129636 E006 69.4557325 0.0015462120 2.598480e-04 0.0012162425 16 47155605 47155671 67 - 1.744 1.921 0.598
ENSG00000129636 E007 120.7338911 0.0002560646 7.377798e-05 0.0003982623 16 47155672 47155778 107 - 1.994 2.132 0.464
ENSG00000129636 E008 124.4995454 0.0002341021 4.556803e-04 0.0019892533 16 47158873 47158934 62 - 2.011 2.133 0.406
ENSG00000129636 E009 129.4993078 0.0002272800 6.039225e-03 0.0187136162 16 47158935 47158990 56 - 2.037 2.131 0.314
ENSG00000129636 E010 152.2322655 0.0002642556 1.195459e-02 0.0334217968 16 47161750 47161832 83 - 2.110 2.190 0.267
ENSG00000129636 E011 125.0851163 0.0002543924 1.106586e-01 0.2065005081 16 47162540 47162601 62 - 2.032 2.088 0.189
ENSG00000129636 E012 107.9855815 0.0015455102 5.451606e-02 0.1171468848 16 47162602 47162664 63 - 1.961 2.039 0.262
ENSG00000129636 E013 104.9813885 0.0003266062 2.655112e-01 0.4035776520 16 47218868 47218946 79 - 1.961 2.004 0.146
ENSG00000129636 E014 77.9950295 0.0008085334 4.261181e-01 0.5689753181 16 47237965 47238008 44 - 1.858 1.821 -0.125
ENSG00000129636 E015 0.2998086 0.0283990495 3.722956e-01   16 47238009 47238289 281 - 0.071 0.204 1.757
ENSG00000129636 E016 115.6256775 0.0028253657 2.666876e-02 0.0653007215 16 47258632 47258740 109 - 2.040 1.939 -0.340
ENSG00000129636 E017 110.7243452 0.0004287293 1.157770e-01 0.2139174689 16 47260545 47260659 115 - 2.012 1.949 -0.209
ENSG00000129636 E018 86.5484812 0.0006975811 5.219330e-02 0.1130614894 16 47260660 47260695 36 - 1.913 1.825 -0.297
ENSG00000129636 E019 0.2903454 0.3746981540 1.000000e+00   16 47262767 47263014 248 - 0.131 0.000 -10.101
ENSG00000129636 E020 168.0659668 0.0004114319 3.601728e-03 0.0120157163 16 47311240 47311412 173 - 2.198 2.103 -0.320
ENSG00000129636 E021 0.1472490 0.0437430659 1.000000e+00   16 47311889 47311913 25 - 0.071 0.000 -9.105
ENSG00000129636 E022 0.0000000       16 47311914 47312275 362 -      
ENSG00000129636 E023 133.5947526 0.0002241454 2.149742e-03 0.0076895584 16 47313729 47313823 95 - 2.103 1.991 -0.374
ENSG00000129636 E024 0.0000000       16 47365571 47365787 217 -      
ENSG00000129636 E025 106.8742086 0.0003589634 2.055184e-03 0.0073965784 16 47365788 47365869 82 - 2.011 1.883 -0.428
ENSG00000129636 E026 106.7967663 0.0014280905 8.900105e-02 0.1736026262 16 47375876 47375940 65 - 1.999 1.925 -0.250
ENSG00000129636 E027 0.1482932 0.0411597534 1.318241e-01   16 47396103 47396220 118 - 0.000 0.203 12.346
ENSG00000129636 E028 0.1515154 0.0434654671 1.000000e+00   16 47425784 47426348 565 - 0.071 0.000 -9.106
ENSG00000129636 E029 123.9788637 0.0003016828 1.782834e-02 0.0467703047 16 47428804 47428898 95 - 2.067 1.978 -0.299
ENSG00000129636 E030 47.2286643 0.0198687286 6.057022e-02 0.1275889651 16 47448098 47450346 2249 - 1.579 1.739 0.542
ENSG00000129636 E031 14.9341828 0.0666087871 1.726966e-03 0.0063677489 16 47450347 47450453 107 - 0.961 1.434 1.684
ENSG00000129636 E032 0.1817044 0.0434609360 1.301877e-01   16 47450454 47450461 8 - 0.000 0.204 12.350
ENSG00000129636 E033 129.0647268 0.0002516118 4.551593e-01 0.5957027091 16 47451396 47451470 75 - 2.068 2.041 -0.090
ENSG00000129636 E034 120.5726318 0.0002989271 9.435426e-02 0.1819129691 16 47452733 47452790 58 - 2.049 1.986 -0.211
ENSG00000129636 E035 169.1946375 0.0007678464 4.893986e-02 0.1072706560 16 47454013 47454158 146 - 2.195 2.128 -0.223
ENSG00000129636 E036 110.2174233 0.0002955721 8.513687e-02 0.1676272241 16 47459103 47459175 73 - 2.009 1.941 -0.230
ENSG00000129636 E037 105.3705630 0.0113860119 1.756298e-01 0.2955090458 16 47460838 47461063 226 - 1.995 1.896 -0.335
ENSG00000129636 E038 5.3907259 0.0085494837 6.256061e-01 0.7417045274 16 47461115 47461274 160 - 0.734 0.806 0.288
ENSG00000129636 E039 0.0000000       16 47461464 47461586 123 -      
ENSG00000129636 E040 0.0000000       16 47463952 47464149 198 -