ENSG00000129625

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379638 ENSG00000129625 HEK293_OSMI2_2hA HEK293_TMG_2hB REEP5 protein_coding protein_coding 161.8531 185.1207 143.8069 9.963406 6.59857 -0.3643107 18.67940 9.836964 28.333449 0.4046285 0.6020218 1.5252644 0.11859167 0.05370000 0.19820000 0.14450000 1.594786e-15 1.594786e-15 FALSE TRUE
ENST00000504247 ENSG00000129625 HEK293_OSMI2_2hA HEK293_TMG_2hB REEP5 protein_coding protein_coding 161.8531 185.1207 143.8069 9.963406 6.59857 -0.3643107 37.52213 38.644660 34.620127 3.8833291 3.1161348 -0.1586147 0.23207083 0.20956667 0.23986667 0.03030000 6.483278e-01 1.594786e-15 FALSE FALSE
ENST00000513339 ENSG00000129625 HEK293_OSMI2_2hA HEK293_TMG_2hB REEP5 protein_coding protein_coding 161.8531 185.1207 143.8069 9.963406 6.59857 -0.3643107 8.35618 10.449851 5.689916 0.7168116 0.6575094 -0.8758497 0.05137083 0.05636667 0.04013333 -0.01623333 2.690194e-01 1.594786e-15 FALSE FALSE
MSTRG.26755.4 ENSG00000129625 HEK293_OSMI2_2hA HEK293_TMG_2hB REEP5 protein_coding   161.8531 185.1207 143.8069 9.963406 6.59857 -0.3643107 63.11575 76.638791 53.821133 8.5412762 2.1378443 -0.5098222 0.38985833 0.41180000 0.37456667 -0.03723333 6.255295e-01 1.594786e-15 FALSE FALSE
MSTRG.26755.8 ENSG00000129625 HEK293_OSMI2_2hA HEK293_TMG_2hB REEP5 protein_coding   161.8531 185.1207 143.8069 9.963406 6.59857 -0.3643107 27.31092 37.865601 18.297750 0.4149270 3.8515251 -1.0488143 0.16612083 0.20606667 0.12580000 -0.08026667 8.640103e-02 1.594786e-15 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129625 E001 638.2189498 0.0072595484 1.163962e-32 2.378739e-30 5 112876385 112878084 1700 - 3.041 2.504 -1.786
ENSG00000129625 E002 209.5397220 0.0053279425 6.314051e-34 1.429125e-31 5 112878085 112878576 492 - 2.570 2.001 -1.901
ENSG00000129625 E003 1140.5684148 0.0006294600 1.747890e-02 4.599830e-02 5 112878577 112878832 256 - 3.047 3.052 0.015
ENSG00000129625 E004 693.9438225 0.0017864622 1.416672e-01 2.503234e-01 5 112878833 112878835 3 - 2.831 2.836 0.018
ENSG00000129625 E005 1581.4714575 0.0005670813 5.193771e-06 3.682150e-05 5 112887015 112887183 169 - 3.175 3.201 0.087
ENSG00000129625 E006 11.3156054 0.0015844045 5.191000e-01 6.532264e-01 5 112892450 112892817 368 - 1.056 1.094 0.136
ENSG00000129625 E007 0.4418608 0.0275249940 6.000154e-02 1.266037e-01 5 112892818 112893382 565 - 0.325 0.000 -10.113
ENSG00000129625 E008 1383.6957208 0.0003347593 9.226413e-14 2.636375e-12 5 112902380 112902518 139 - 3.098 3.154 0.185
ENSG00000129625 E009 1089.0262329 0.0012631932 3.267202e-08 3.652769e-07 5 112921163 112921256 94 - 2.985 3.052 0.224
ENSG00000129625 E010 4.5412797 0.0037670322 4.020965e-01 5.458022e-01 5 112921257 112921479 223 - 0.673 0.767 0.387
ENSG00000129625 E011 3.3129997 0.0618911716 7.072604e-02 1.445460e-01 5 112921480 112921672 193 - 0.395 0.705 1.456
ENSG00000129625 E012 1.4372407 0.0090635308 1.994497e-01 3.255516e-01 5 112921720 112922045 326 - 0.509 0.269 -1.378
ENSG00000129625 E013 2.6258515 0.0056703706 6.988293e-01 7.987060e-01 5 112922046 112922072 27 - 0.599 0.516 -0.379
ENSG00000129625 E014 1058.8155833 0.0016142792 1.446111e-02 3.927143e-02 5 112922073 112922289 217 - 3.006 3.020 0.047