ENSG00000129534

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310806 ENSG00000129534 HEK293_OSMI2_2hA HEK293_TMG_2hB MIS18BP1 protein_coding protein_coding 9.255958 1.826074 15.59042 0.2541933 0.3151103 3.086889 1.6750245 0.29137322 2.7809155 0.11587695 0.4440692 3.2111153 0.1464958 0.17553333 0.17883333 0.00330000 0.9504560729 0.0001713592 FALSE TRUE
ENST00000469020 ENSG00000129534 HEK293_OSMI2_2hA HEK293_TMG_2hB MIS18BP1 protein_coding retained_intron 9.255958 1.826074 15.59042 0.2541933 0.3151103 3.086889 1.7258321 0.08311265 3.0823130 0.08311265 0.1326699 5.0535654 0.1428958 0.03600000 0.19810000 0.16210000 0.0721389613 0.0001713592 FALSE TRUE
ENST00000470424 ENSG00000129534 HEK293_OSMI2_2hA HEK293_TMG_2hB MIS18BP1 protein_coding retained_intron 9.255958 1.826074 15.59042 0.2541933 0.3151103 3.086889 0.4349997 0.15666198 0.2268884 0.04094090 0.2268884 0.5072825 0.0928875 0.09446667 0.01470000 -0.07976667 0.1232244143 0.0001713592   FALSE
ENST00000496413 ENSG00000129534 HEK293_OSMI2_2hA HEK293_TMG_2hB MIS18BP1 protein_coding retained_intron 9.255958 1.826074 15.59042 0.2541933 0.3151103 3.086889 0.6883564 0.00000000 1.1764721 0.00000000 0.5916974 6.8905344 0.0737750 0.00000000 0.07500000 0.07500000 0.4988230491 0.0001713592   FALSE
MSTRG.9468.2 ENSG00000129534 HEK293_OSMI2_2hA HEK293_TMG_2hB MIS18BP1 protein_coding   9.255958 1.826074 15.59042 0.2541933 0.3151103 3.086889 0.5056004 1.10318959 0.1663002 0.10728144 0.1663002 -2.6585931 0.1763208 0.61096667 0.01076667 -0.60020000 0.0001713592 0.0001713592 FALSE TRUE
MSTRG.9468.4 ENSG00000129534 HEK293_OSMI2_2hA HEK293_TMG_2hB MIS18BP1 protein_coding   9.255958 1.826074 15.59042 0.2541933 0.3151103 3.086889 2.8772121 0.13298247 5.3596723 0.13298247 0.5132343 5.2309239 0.2540292 0.05760000 0.34513333 0.28753333 0.0602670079 0.0001713592 FALSE TRUE
MSTRG.9468.5 ENSG00000129534 HEK293_OSMI2_2hA HEK293_TMG_2hB MIS18BP1 protein_coding   9.255958 1.826074 15.59042 0.2541933 0.3151103 3.086889 0.2969594 0.00000000 0.7911466 0.00000000 0.4270350 6.3239943 0.0318625 0.00000000 0.05016667 0.05016667 0.5501769248 0.0001713592 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129534 E001 0.0000000       14 45203119 45203159 41 -      
ENSG00000129534 E002 0.0000000       14 45203160 45203189 30 -      
ENSG00000129534 E003 0.6298062 0.0254270124 3.519534e-03 1.178322e-02 14 45203190 45203197 8 - 0.047 0.574 4.580
ENSG00000129534 E004 20.2245047 0.0088358431 9.356593e-27 1.181116e-24 14 45203198 45203441 244 - 0.858 1.809 3.352
ENSG00000129534 E005 46.3922120 0.0176324145 4.633356e-13 1.200459e-11 14 45203442 45203836 395 - 1.364 1.974 2.077
ENSG00000129534 E006 61.1197136 0.0005593895 3.089397e-09 4.180550e-08 14 45203837 45204212 376 - 1.560 1.909 1.181
ENSG00000129534 E007 0.9598037 0.0797902337 1.421584e-04 7.127936e-04 14 45204380 45204398 19 - 0.047 0.744 5.305
ENSG00000129534 E008 41.3137441 0.0066702151 2.493948e-02 6.174557e-02 14 45204399 45204453 55 - 1.429 1.628 0.679
ENSG00000129534 E009 47.6336211 0.0005006431 6.586163e-01 7.676776e-01 14 45206083 45206170 88 - 1.514 1.567 0.182
ENSG00000129534 E010 5.2989281 0.0249138624 9.759883e-01 9.890135e-01 14 45206171 45206444 274 - 0.660 0.670 0.043
ENSG00000129534 E011 6.6634347 0.0037669845 2.893632e-01 4.300439e-01 14 45210111 45210379 269 - 0.757 0.575 -0.773
ENSG00000129534 E012 51.3921739 0.0004370549 1.834709e-01 3.055541e-01 14 45210380 45210462 83 - 1.535 1.646 0.379
ENSG00000129534 E013 49.3676095 0.0004836233 4.420880e-01 5.837451e-01 14 45210463 45210528 66 - 1.523 1.598 0.258
ENSG00000129534 E014 71.5142306 0.0004013926 7.045194e-01 8.030535e-01 14 45217019 45217179 161 - 1.684 1.728 0.150
ENSG00000129534 E015 67.7362263 0.0003982074 3.353868e-01 4.791706e-01 14 45218282 45218432 151 - 1.656 1.736 0.269
ENSG00000129534 E016 28.2114021 0.0007308816 9.099303e-01 9.467348e-01 14 45218433 45218454 22 - 1.296 1.327 0.111
ENSG00000129534 E017 193.4313819 0.0002347252 4.244744e-01 5.674405e-01 14 45223918 45224746 829 - 2.117 2.111 -0.023
ENSG00000129534 E018 40.1237520 0.0095749233 3.352569e-01 4.790320e-01 14 45226743 45226825 83 - 1.428 1.536 0.373
ENSG00000129534 E019 22.3528174 0.0086703961 5.758274e-02 1.224726e-01 14 45226826 45226836 11 - 1.164 1.383 0.771
ENSG00000129534 E020 32.4259777 0.0006622566 7.534774e-01 8.393971e-01 14 45227663 45227686 24 - 1.348 1.397 0.169
ENSG00000129534 E021 52.8258313 0.0013972339 1.667310e-02 4.421861e-02 14 45227687 45227802 116 - 1.582 1.413 -0.581
ENSG00000129534 E022 29.6368999 0.0026439883 9.530913e-03 2.761466e-02 14 45227803 45227814 12 - 1.348 1.081 -0.946
ENSG00000129534 E023 58.9206713 0.0051852942 6.494466e-02 1.349431e-01 14 45231141 45231298 158 - 1.622 1.498 -0.421
ENSG00000129534 E024 0.2924217 0.0272014484 1.000000e+00   14 45231299 45231441 143 - 0.090 0.000 -8.531
ENSG00000129534 E025 0.7384352 0.0182023069 6.861749e-01 7.887588e-01 14 45232509 45232572 64 - 0.197 0.000 -9.848
ENSG00000129534 E026 1.0308569 0.0200309626 4.320279e-01 5.744882e-01 14 45232573 45232627 55 - 0.257 0.000 -10.278
ENSG00000129534 E027 32.7742398 0.0014162400 7.088548e-02 1.448125e-01 14 45232733 45232820 88 - 1.378 1.222 -0.548
ENSG00000129534 E028 49.2271427 0.0004321679 2.901822e-02 7.004503e-02 14 45235814 45235944 131 - 1.550 1.397 -0.529
ENSG00000129534 E029 0.4386386 0.1914773305 2.998711e-01 4.414631e-01 14 45237172 45237280 109 - 0.090 0.281 1.987
ENSG00000129534 E030 29.9878521 0.0006345217 1.432319e-02 3.896391e-02 14 45237648 45237696 49 - 1.353 1.113 -0.847
ENSG00000129534 E031 23.7038371 0.0007988452 3.881493e-03 1.281098e-02 14 45237697 45237721 25 - 1.264 0.922 -1.239
ENSG00000129534 E032 0.1451727 0.0428675090 7.278955e-01   14 45241468 45241870 403 - 0.047 0.000 -7.445
ENSG00000129534 E033 96.6474627 0.0016868398 1.955284e-08 2.285149e-07 14 45242034 45242518 485 - 1.855 1.497 -1.216
ENSG00000129534 E034 42.4827149 0.0007826793 3.337511e-06 2.474199e-05 14 45242761 45242874 114 - 1.509 1.046 -1.628
ENSG00000129534 E035 32.3993309 0.0006697152 4.285926e-09 5.647995e-08 14 45246743 45246820 78 - 1.411 0.575 -3.164
ENSG00000129534 E036 79.2831001 0.0004126205 6.636715e-10 1.017897e-08 14 45246821 45247377 557 - 1.774 1.327 -1.529
ENSG00000129534 E037 5.5338154 0.0030599022 4.632017e-02 1.026125e-01 14 45250031 45250138 108 - 0.711 0.283 -2.170
ENSG00000129534 E038 1.3402305 0.0224067570 2.957675e-01 4.369192e-01 14 45252818 45253034 217 - 0.309 0.000 -10.587
ENSG00000129534 E039 15.3362667 0.0139526346 1.370292e-01 2.439554e-01 14 45253035 45253540 506 - 1.076 0.872 -0.759