ENSG00000129515

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000556303 ENSG00000129515 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX6 protein_coding retained_intron 38.01522 9.747815 67.78698 0.6646261 2.661508 2.796591 6.039047 0.1090525 14.55025 0.1090525 1.573988 6.934294 0.0897625 0.01250000 0.2136 0.2011000 7.506075e-03 3.763451e-15 FALSE TRUE
ENST00000557265 ENSG00000129515 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX6 protein_coding protein_coding 38.01522 9.747815 67.78698 0.6646261 2.661508 2.796591 7.828933 0.2586711 17.11822 0.2586711 0.530703 5.994390 0.1181667 0.02713333 0.2527 0.2255667 3.761058e-02 3.763451e-15 FALSE FALSE
ENST00000652385 ENSG00000129515 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX6 protein_coding protein_coding 38.01522 9.747815 67.78698 0.6646261 2.661508 2.796591 20.551619 8.3446306 31.47663 0.7990889 1.100236 1.914092 0.6907083 0.85286667 0.4646 -0.3882667 3.763451e-15 3.763451e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129515 E001 0.0000000       14 34561093 34561093 1 -      
ENSG00000129515 E002 0.0000000       14 34561094 34561411 318 -      
ENSG00000129515 E003 2.8648409 0.0920063239 1.484007e-02 4.012913e-02 14 34561412 34561945 534 - 0.364 0.874 2.306
ENSG00000129515 E004 238.0749616 0.0174883130 5.485179e-07 4.814672e-06 14 34561946 34562639 694 - 2.170 2.565 1.318
ENSG00000129515 E005 69.5810482 0.0164351104 3.568701e-15 1.254555e-13 14 34562640 34562659 20 - 1.527 2.185 2.220
ENSG00000129515 E006 338.8574418 0.0022961201 1.085138e-19 6.668055e-18 14 34562660 34563175 516 - 2.350 2.669 1.062
ENSG00000129515 E007 149.2076087 0.0031342360 2.896642e-02 6.994228e-02 14 34567686 34567762 77 - 2.045 2.188 0.477
ENSG00000129515 E008 86.0829420 0.0022229343 8.343317e-02 1.649368e-01 14 34567763 34567771 9 - 1.812 1.948 0.459
ENSG00000129515 E009 109.3105567 0.0003097949 2.619472e-01 3.996625e-01 14 34567854 34567891 38 - 1.924 2.020 0.324
ENSG00000129515 E010 191.4994241 0.0001805768 7.640309e-02 1.537484e-01 14 34567892 34568013 122 - 2.163 2.268 0.350
ENSG00000129515 E011 0.1515154 0.0426484427 1.000000e+00   14 34575591 34575755 165 - 0.059 0.000 -7.888
ENSG00000129515 E012 143.8748253 0.0002555577 8.923452e-01 9.352245e-01 14 34575756 34575842 87 - 2.050 2.105 0.186
ENSG00000129515 E013 97.2528991 0.0003524889 4.130863e-02 9.344792e-02 14 34581561 34581600 40 - 1.902 1.858 -0.149
ENSG00000129515 E014 149.3796723 0.0004581763 1.790317e-02 4.692709e-02 14 34586230 34586305 76 - 2.086 2.047 -0.132
ENSG00000129515 E015 0.1451727 0.0427773461 1.000000e+00   14 34586306 34586316 11 - 0.059 0.000 -7.887
ENSG00000129515 E016 208.4215332 0.0016926339 1.692006e-02 4.475703e-02 14 34593045 34593150 106 - 2.228 2.190 -0.128
ENSG00000129515 E017 223.6230551 0.0003543190 1.897900e-03 6.907808e-03 14 34597550 34597645 96 - 2.260 2.214 -0.154
ENSG00000129515 E018 129.1114618 0.0024266529 8.550488e-03 2.516685e-02 14 34603348 34603364 17 - 2.029 1.952 -0.256
ENSG00000129515 E019 230.2940823 0.0050076505 5.524151e-03 1.734999e-02 14 34603365 34603471 107 - 2.278 2.196 -0.272
ENSG00000129515 E020 1.3578477 0.0118510312 5.609443e-01 6.888566e-01 14 34604135 34604174 40 - 0.336 0.237 -0.683
ENSG00000129515 E021 1.6608786 0.0170223155 4.002572e-01 5.439550e-01 14 34604175 34604268 94 - 0.391 0.237 -1.005
ENSG00000129515 E022 0.1817044 0.0408420614 9.181822e-02   14 34605487 34605595 109 - 0.000 0.237 12.246
ENSG00000129515 E023 279.7258980 0.0001876500 1.668246e-10 2.835748e-09 14 34605596 34605681 86 - 2.371 2.240 -0.435
ENSG00000129515 E024 222.2695664 0.0003970909 6.876441e-09 8.737817e-08 14 34605682 34605717 36 - 2.272 2.132 -0.468
ENSG00000129515 E025 265.6944748 0.0001800308 1.759177e-06 1.385380e-05 14 34608030 34608140 111 - 2.341 2.256 -0.284
ENSG00000129515 E026 216.4045911 0.0001951204 1.119100e-07 1.126994e-06 14 34609638 34609742 105 - 2.258 2.138 -0.401
ENSG00000129515 E027 0.5922303 0.0179784653 7.376222e-01 8.277329e-01 14 34629458 34629906 449 - 0.158 0.237 0.730
ENSG00000129515 E028 127.9349749 0.0002529948 4.418372e-06 3.183537e-05 14 34629907 34629950 44 - 2.036 1.892 -0.483
ENSG00000129515 E029 82.7701450 0.0022080374 7.685278e-08 7.979573e-07 14 34629951 34629954 4 - 1.867 1.588 -0.943
ENSG00000129515 E030 4.8089961 0.0058802971 4.784164e-02 1.053413e-01 14 34629955 34630109 155 - 0.730 0.390 -1.591
ENSG00000129515 E031 79.0080273 0.0032544065 2.732526e-07 2.549089e-06 14 34630111 34630188 78 - 1.847 1.563 -0.963