ENSG00000129484

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250416 ENSG00000129484 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP2 protein_coding protein_coding 45.39778 33.52286 49.11621 2.932632 0.4371939 0.5509175 17.588024 15.164781 20.071153 0.9142445 1.0688292 0.404166381 0.38750000 0.45513333 0.40903333 -0.04610000 0.603934450 0.000245831 FALSE  
ENST00000429687 ENSG00000129484 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP2 protein_coding protein_coding 45.39778 33.52286 49.11621 2.932632 0.4371939 0.5509175 9.962195 10.166020 10.097626 0.5061516 0.4136244 -0.009729181 0.22800000 0.30530000 0.20553333 -0.09976667 0.000245831 0.000245831 FALSE  
ENST00000527915 ENSG00000129484 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP2 protein_coding protein_coding 45.39778 33.52286 49.11621 2.932632 0.4371939 0.5509175 6.000064 2.816864 6.167983 0.5044681 0.7640092 1.127933364 0.13055000 0.08293333 0.12550000 0.04256667 0.227354628 0.000245831 FALSE  
ENST00000530598 ENSG00000129484 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP2 protein_coding retained_intron 45.39778 33.52286 49.11621 2.932632 0.4371939 0.5509175 2.804517 1.414255 2.687182 0.2706737 0.2772465 0.921245633 0.06120417 0.04150000 0.05463333 0.01313333 0.466932293 0.000245831 FALSE  
MSTRG.9147.1 ENSG00000129484 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP2 protein_coding   45.39778 33.52286 49.11621 2.932632 0.4371939 0.5509175 2.378440 1.046945 2.449244 0.1633611 0.3821833 1.218313882 0.05026667 0.03123333 0.04990000 0.01866667 0.299709768 0.000245831 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129484 E001 3.0871929 0.0229120518 5.854760e-01 7.091723e-01 14 20343554 20343614 61 + 0.663 0.581 -0.355
ENSG00000129484 E002 9.7766047 0.0628949287 3.985957e-01 5.423287e-01 14 20343615 20343627 13 + 1.103 0.969 -0.489
ENSG00000129484 E003 13.0387068 0.0040416939 2.481770e-01 3.837821e-01 14 20343628 20343634 7 + 1.204 1.101 -0.367
ENSG00000129484 E004 13.3352931 0.0059806585 3.647094e-01 5.090481e-01 14 20343635 20343636 2 + 1.204 1.124 -0.284
ENSG00000129484 E005 83.7882770 0.0006403631 9.845584e-09 1.215837e-07 14 20343637 20343687 51 + 2.028 1.803 -0.757
ENSG00000129484 E006 215.9473305 0.0006089490 6.540373e-08 6.886694e-07 14 20344932 20345087 156 + 2.401 2.265 -0.454
ENSG00000129484 E007 109.2831779 0.0002941847 2.899710e-03 9.968271e-03 14 20345088 20345126 39 + 2.089 1.995 -0.317
ENSG00000129484 E008 195.6795028 0.0009552335 7.148821e-04 2.951945e-03 14 20345394 20345464 71 + 2.338 2.246 -0.307
ENSG00000129484 E009 186.0728253 0.0024944552 6.170671e-02 1.295006e-01 14 20346863 20346913 51 + 2.302 2.239 -0.212
ENSG00000129484 E010 261.2847384 0.0035336072 4.754204e-02 1.048046e-01 14 20350526 20350622 97 + 2.452 2.382 -0.232
ENSG00000129484 E011 1.8069817 0.0076724903 3.223122e-02 7.629965e-02 14 20350699 20351046 348 + 0.602 0.232 -2.087
ENSG00000129484 E012 214.0944115 0.0033834872 2.531943e-02 6.252692e-02 14 20351047 20351122 76 + 2.372 2.291 -0.271
ENSG00000129484 E013 260.4973493 0.0002281191 4.490985e-02 1.000345e-01 14 20352245 20352347 103 + 2.438 2.400 -0.128
ENSG00000129484 E014 0.9212829 0.0202431803 5.398948e-01 6.711073e-01 14 20352513 20353003 491 + 0.204 0.314 0.824
ENSG00000129484 E015 303.4116343 0.0001691228 4.875715e-02 1.069556e-01 14 20354085 20354247 163 + 2.501 2.468 -0.112
ENSG00000129484 E016 14.8337896 0.0590568059 9.601418e-03 2.778183e-02 14 20354642 20354808 167 + 1.354 0.972 -1.367
ENSG00000129484 E017 146.3520939 0.0002200034 8.652011e-01 9.171572e-01 14 20354809 20354834 26 + 2.166 2.178 0.040
ENSG00000129484 E018 244.8582295 0.0002407512 5.153837e-01 6.500635e-01 14 20354835 20354947 113 + 2.380 2.402 0.072
ENSG00000129484 E019 23.2514554 0.0008138001 3.715564e-05 2.158085e-04 14 20355161 20355751 591 + 1.512 1.218 -1.020
ENSG00000129484 E020 178.1920352 0.0002614444 3.063785e-01 4.485405e-01 14 20355752 20355781 30 + 2.236 2.270 0.113
ENSG00000129484 E021 152.9534276 0.0002591282 5.995995e-01 7.209602e-01 14 20355782 20355795 14 + 2.176 2.198 0.072
ENSG00000129484 E022 143.2144754 0.0002247154 1.304382e-01 2.347672e-01 14 20355796 20355815 20 + 2.134 2.186 0.172
ENSG00000129484 E023 143.0978843 0.0002400849 9.522968e-02 1.832167e-01 14 20355897 20355909 13 + 2.134 2.190 0.188
ENSG00000129484 E024 291.6475115 0.0006364456 5.637112e-02 1.203753e-01 14 20355910 20356031 122 + 2.442 2.492 0.168
ENSG00000129484 E025 338.6796098 0.0001606373 3.022037e-03 1.033161e-02 14 20356307 20356434 128 + 2.501 2.565 0.213
ENSG00000129484 E026 13.4665654 0.0013267672 1.278017e-03 4.904024e-03 14 20356435 20356589 155 + 1.286 0.992 -1.052
ENSG00000129484 E027 251.2411844 0.0005209801 6.324570e-05 3.473160e-04 14 20356590 20356689 100 + 2.351 2.455 0.346
ENSG00000129484 E028 2.4712181 0.0060491183 8.281951e-02 1.639643e-01 14 20356690 20356750 61 + 0.663 0.382 -1.350
ENSG00000129484 E029 267.7426657 0.0017604526 5.881879e-05 3.255820e-04 14 20357051 20357149 99 + 2.366 2.490 0.413
ENSG00000129484 E030 22.3764523 0.0010351409 1.354738e-02 3.719149e-02 14 20357150 20357395 246 + 1.452 1.279 -0.601
ENSG00000129484 E031 272.9196199 0.0041122063 2.512759e-04 1.180612e-03 14 20357396 20357520 125 + 2.362 2.506 0.482
ENSG00000129484 E032 36.6776277 0.0057999791 5.500243e-02 1.180006e-01 14 20357521 20357637 117 + 1.637 1.518 -0.405
ENSG00000129484 E033 254.1262212 0.0056383014 3.509975e-03 1.175454e-02 14 20357638 20357904 267 + 2.338 2.471 0.445