ENSG00000129422

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381869 ENSG00000129422 HEK293_OSMI2_2hA HEK293_TMG_2hB MTUS1 protein_coding protein_coding 2.712424 1.595173 2.918108 0.04838953 0.03039451 0.8672404 0.17699835 0.21695521 0.10838283 0.12315488 0.10838283 -0.9389478 0.06485833 0.1322333 0.03650000 -0.09573333 0.325149046 0.006380127 FALSE TRUE
ENST00000519263 ENSG00000129422 HEK293_OSMI2_2hA HEK293_TMG_2hB MTUS1 protein_coding protein_coding 2.712424 1.595173 2.918108 0.04838953 0.03039451 0.8672404 0.04539125 0.00000000 0.15202227 0.00000000 0.15202227 4.0181202 0.01274583 0.0000000 0.05203333 0.05203333 0.904806952 0.006380127 FALSE TRUE
ENST00000523471 ENSG00000129422 HEK293_OSMI2_2hA HEK293_TMG_2hB MTUS1 protein_coding retained_intron 2.712424 1.595173 2.918108 0.04838953 0.03039451 0.8672404 0.16765767 0.02831107 0.06954687 0.02831107 0.03518958 1.0540439 0.05555000 0.0168000 0.02360000 0.00680000 0.839054869 0.006380127 FALSE FALSE
ENST00000544260 ENSG00000129422 HEK293_OSMI2_2hA HEK293_TMG_2hB MTUS1 protein_coding protein_coding 2.712424 1.595173 2.918108 0.04838953 0.03039451 0.8672404 0.54484149 0.96526855 0.11757401 0.11569241 0.11757401 -2.9344651 0.27262917 0.6088000 0.04023333 -0.56856667 0.006380127 0.006380127 FALSE TRUE
ENST00000693296 ENSG00000129422 HEK293_OSMI2_2hA HEK293_TMG_2hB MTUS1 protein_coding protein_coding 2.712424 1.595173 2.918108 0.04838953 0.03039451 0.8672404 1.32137843 0.26857658 1.94931427 0.19766145 0.15622455 2.8142030 0.43215833 0.1715333 0.66916667 0.49763333 0.054482574 0.006380127 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129422 E001 0.0000000       8 17643795 17643798 4 -      
ENSG00000129422 E002 0.4031496 0.0248753483 5.815684e-02 1.234663e-01 8 17643799 17643801 3 - 0.000 0.303 12.074
ENSG00000129422 E003 0.4031496 0.0248753483 5.815684e-02 1.234663e-01 8 17643802 17643803 2 - 0.000 0.303 14.576
ENSG00000129422 E004 116.9167996 0.0034842364 1.295187e-24 1.363162e-22 8 17643804 17645560 1757 - 1.874 2.266 1.317
ENSG00000129422 E005 8.6526903 0.0196531495 1.420756e-01 2.508632e-01 8 17645561 17645661 101 - 0.888 1.098 0.776
ENSG00000129422 E006 16.4526059 0.0012845062 9.053204e-01 9.437173e-01 8 17645662 17645868 207 - 1.207 1.246 0.138
ENSG00000129422 E007 10.0261065 0.0017921416 1.885861e-01 3.119532e-01 8 17645869 17645925 57 - 1.053 0.933 -0.444
ENSG00000129422 E008 12.2615810 0.0015087462 3.464599e-01 4.905871e-01 8 17645926 17645975 50 - 1.113 1.045 -0.246
ENSG00000129422 E009 17.5676430 0.0010844977 1.120066e-01 2.084924e-01 8 17645976 17646135 160 - 1.275 1.165 -0.390
ENSG00000129422 E010 6.8949053 0.0048050537 1.289739e-01 2.327421e-01 8 17646136 17646139 4 - 0.922 0.744 -0.694
ENSG00000129422 E011 9.6712306 0.0018207880 8.162517e-02 1.621012e-01 8 17646982 17647003 22 - 1.053 0.878 -0.650
ENSG00000129422 E012 14.8624720 0.0012449587 1.323928e-01 2.374146e-01 8 17647004 17647079 76 - 1.213 1.100 -0.403
ENSG00000129422 E013 0.1515154 0.0429161036 1.000000e+00   8 17647080 17647278 199 - 0.083 0.000 -12.842
ENSG00000129422 E014 11.3517781 0.0016994982 2.123632e-01 3.413186e-01 8 17649846 17649879 34 - 1.106 1.003 -0.375
ENSG00000129422 E015 15.3112628 0.0011975139 7.798798e-01 8.585036e-01 8 17649880 17649962 83 - 1.190 1.194 0.013
ENSG00000129422 E016 0.6653823 0.0172671820 8.075875e-01 8.777486e-01 8 17651603 17651764 162 - 0.212 0.177 -0.320
ENSG00000129422 E017 13.4897334 0.0035866738 9.583237e-01 9.778974e-01 8 17653186 17653281 96 - 1.127 1.150 0.083
ENSG00000129422 E018 12.1895975 0.0014954866 8.938517e-01 9.361250e-01 8 17653425 17653498 74 - 1.076 1.118 0.149
ENSG00000129422 E019 2.6677980 0.0058307551 8.956624e-01 9.373498e-01 8 17653499 17654560 1062 - 0.547 0.547 0.000
ENSG00000129422 E020 6.5773908 0.0025657043 1.734320e-01 2.926505e-01 8 17654561 17654563 3 - 0.899 0.744 -0.610
ENSG00000129422 E021 10.4921778 0.0017710804 3.628559e-01 5.072684e-01 8 17654564 17654666 103 - 1.053 0.981 -0.263
ENSG00000129422 E022 0.6611159 0.0273213772 8.094324e-01 8.789819e-01 8 17654667 17655025 359 - 0.212 0.178 -0.318
ENSG00000129422 E023 5.1444153 0.0033120058 4.032459e-01 5.470327e-01 8 17655863 17655870 8 - 0.796 0.702 -0.380
ENSG00000129422 E024 12.8394455 0.0015167634 3.360100e-02 7.896798e-02 8 17655871 17656018 148 - 1.172 0.981 -0.693
ENSG00000129422 E025 4.1759015 0.0037787972 5.731552e-01 6.991453e-01 8 17656019 17656025 7 - 0.716 0.656 -0.251
ENSG00000129422 E026 6.7128993 0.0025564997 1.220695e-01 2.228918e-01 8 17656026 17656065 40 - 0.922 0.743 -0.696
ENSG00000129422 E027 0.0000000       8 17663980 17664081 102 -      
ENSG00000129422 E028 0.0000000       8 17674668 17674734 67 -      
ENSG00000129422 E029 0.0000000       8 17674735 17674836 102 -      
ENSG00000129422 E030 0.0000000       8 17674837 17675015 179 -      
ENSG00000129422 E031 6.4946738 0.0024876168 3.123018e-01 4.548431e-01 8 17675186 17675216 31 - 0.888 0.781 -0.415
ENSG00000129422 E032 7.1372541 0.0023254879 2.977217e-01 4.390664e-01 8 17675217 17675252 36 - 0.922 0.816 -0.407
ENSG00000129422 E033 0.1472490 0.0435136582 1.000000e+00   8 17675253 17675264 12 - 0.083 0.000 -12.840
ENSG00000129422 E034 0.0000000       8 17675988 17676008 21 -      
ENSG00000129422 E035 0.0000000       8 17676009 17676275 267 -      
ENSG00000129422 E036 0.2214452 0.0401745740 2.160189e-01   8 17676276 17676494 219 - 0.000 0.178 13.575
ENSG00000129422 E037 5.2413144 0.0030886101 3.449843e-01 4.890641e-01 8 17684328 17684334 7 - 0.810 0.702 -0.437
ENSG00000129422 E038 5.3166565 0.0031173750 3.462059e-01 4.903603e-01 8 17684335 17684353 19 - 0.810 0.702 -0.437
ENSG00000129422 E039 11.0838429 0.0021880297 2.738868e-01 4.129883e-01 8 17684354 17684474 121 - 1.091 1.003 -0.322
ENSG00000129422 E040 8.6961705 0.0021063470 7.063057e-01 8.044652e-01 8 17684475 17684542 68 - 0.973 0.957 -0.059
ENSG00000129422 E041 0.0000000       8 17691305 17691364 60 -      
ENSG00000129422 E042 0.1472490 0.0435136582 1.000000e+00   8 17691969 17692141 173 - 0.083 0.000 -12.840
ENSG00000129422 E043 0.1472490 0.0435136582 1.000000e+00   8 17692142 17692226 85 - 0.083 0.000 -12.840
ENSG00000129422 E044 0.0000000       8 17693252 17693338 87 -      
ENSG00000129422 E045 0.0000000       8 17697257 17697670 414 -      
ENSG00000129422 E046 0.0000000       8 17708767 17708968 202 -      
ENSG00000129422 E047 7.1891243 0.0023982869 8.046100e-01 8.756776e-01 8 17713214 17713252 39 - 0.876 0.933 0.216
ENSG00000129422 E048 10.0348999 0.0282857937 9.727055e-01 9.869803e-01 8 17715767 17715901 135 - 1.010 1.045 0.128
ENSG00000129422 E049 0.0000000       8 17716473 17716590 118 -      
ENSG00000129422 E050 0.0000000       8 17721712 17722420 709 -      
ENSG00000129422 E051 0.0000000       8 17722421 17722568 148 -      
ENSG00000129422 E052 0.0000000       8 17722569 17722639 71 -      
ENSG00000129422 E053 0.0000000       8 17723241 17723671 431 -      
ENSG00000129422 E054 5.5390729 0.0074165822 4.451824e-01 5.867514e-01 8 17723672 17723833 162 - 0.824 0.743 -0.323
ENSG00000129422 E055 0.0000000       8 17723834 17724010 177 -      
ENSG00000129422 E056 0.0000000       8 17724102 17724162 61 -      
ENSG00000129422 E057 0.0000000       8 17734203 17734247 45 -      
ENSG00000129422 E058 9.6980185 0.0023193891 7.526014e-01 8.387439e-01 8 17743604 17743799 196 - 0.983 1.045 0.228
ENSG00000129422 E059 60.9659529 0.0007169734 1.415734e-08 1.697509e-07 8 17753717 17755437 1721 - 1.833 1.578 -0.863
ENSG00000129422 E060 11.4966091 0.0137371782 1.943234e-02 5.027189e-02 8 17755438 17755620 183 - 1.140 0.880 -0.960
ENSG00000129422 E061 14.1098158 0.0018506799 5.952436e-02 1.258084e-01 8 17755621 17755961 341 - 1.202 1.045 -0.564
ENSG00000129422 E062 0.0000000       8 17755962 17755981 20 -      
ENSG00000129422 E063 0.5911862 0.0172671820 1.782830e-01 2.989854e-01 8 17758140 17758204 65 - 0.265 0.000 -14.729
ENSG00000129422 E064 0.2987644 0.0273177899 5.236935e-01   8 17770429 17770581 153 - 0.152 0.000 -13.823
ENSG00000129422 E065 0.0000000       8 17780877 17780962 86 -      
ENSG00000129422 E066 0.0000000       8 17800598 17800917 320 -      
ENSG00000129422 E067 2.3700552 0.0064004973 1.563730e-02 4.192823e-02 8 17801061 17801205 145 - 0.618 0.177 -2.644