ENSG00000129353

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407327 ENSG00000129353 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A2 protein_coding protein_coding 27.11168 35.90222 18.09319 1.593999 0.3305573 -0.9882307 17.486484 22.233085 12.019641 2.2733111 0.07999423 -0.886763257 0.64890833 0.62126667 0.66463333 0.04336667 8.571434e-01 2.194947e-08 FALSE TRUE
ENST00000589561 ENSG00000129353 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A2 protein_coding retained_intron 27.11168 35.90222 18.09319 1.593999 0.3305573 -0.9882307 1.318244 1.020756 1.018224 0.3297241 0.14042389 -0.003547418 0.05074583 0.02916667 0.05633333 0.02716667 2.637628e-01 2.194947e-08 FALSE TRUE
ENST00000590382 ENSG00000129353 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A2 protein_coding protein_coding 27.11168 35.90222 18.09319 1.593999 0.3305573 -0.9882307 3.783466 3.483756 2.758019 0.8749949 0.46546479 -0.335925229 0.14688333 0.09536667 0.15196667 0.05660000 3.143080e-01 2.194947e-08 FALSE FALSE
ENST00000590475 ENSG00000129353 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A2 protein_coding retained_intron 27.11168 35.90222 18.09319 1.593999 0.3305573 -0.9882307 2.082843 6.740066 0.000000 2.7574364 0.00000000 -9.398757744 0.05997500 0.18860000 0.00000000 -0.18860000 2.194947e-08 2.194947e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129353 E001 31.6979383 0.0031190210 4.421154e-03 1.432216e-02 19 10602457 10602509 53 + 1.580 1.415 -0.568
ENSG00000129353 E002 46.8875035 0.0082709238 2.936215e-03 1.007586e-02 19 10602510 10602561 52 + 1.751 1.579 -0.583
ENSG00000129353 E003 0.1515154 0.0429908035 2.456977e-01   19 10625520 10625524 5 + 0.160 0.000 -11.414
ENSG00000129353 E004 0.1515154 0.0429908035 2.456977e-01   19 10625525 10625549 25 + 0.160 0.000 -11.414
ENSG00000129353 E005 0.0000000       19 10625550 10625552 3 +      
ENSG00000129353 E006 1.4695060 0.0093023322 1.763724e-01 2.965242e-01 19 10625553 10625593 41 + 0.509 0.290 -1.233
ENSG00000129353 E007 2.7678150 0.0055337409 2.457359e-01 3.809151e-01 19 10625594 10625670 77 + 0.660 0.496 -0.742
ENSG00000129353 E008 57.5762285 0.0030789593 1.201462e-05 7.837120e-05 19 10626253 10626301 49 + 1.860 1.654 -0.697
ENSG00000129353 E009 72.7025481 0.0052058178 6.051197e-06 4.228317e-05 19 10627722 10627795 74 + 1.966 1.750 -0.728
ENSG00000129353 E010 88.8669132 0.0030676055 4.233801e-05 2.426357e-04 19 10627920 10628004 85 + 2.019 1.859 -0.538
ENSG00000129353 E011 100.9007261 0.0050221847 9.293939e-03 2.701966e-02 19 10631057 10631141 85 + 2.032 1.935 -0.326
ENSG00000129353 E012 123.2033755 0.0075077903 8.611774e-03 2.531695e-02 19 10631275 10631385 111 + 2.123 2.019 -0.346
ENSG00000129353 E013 99.9585268 0.0007066869 2.908093e-02 7.016334e-02 19 10631475 10631535 61 + 2.000 1.944 -0.188
ENSG00000129353 E014 120.0763528 0.0003021836 2.296326e-04 1.090415e-03 19 10631626 10631705 80 + 2.109 2.013 -0.323
ENSG00000129353 E015 100.3983495 0.0007307846 2.977504e-04 1.370521e-03 19 10631706 10631749 44 + 2.039 1.930 -0.367
ENSG00000129353 E016 125.0074065 0.0003055723 5.047631e-05 2.842032e-04 19 10631868 10631951 84 + 2.133 2.027 -0.355
ENSG00000129353 E017 129.7879331 0.0004064314 5.960898e-05 3.295034e-04 19 10632044 10632156 113 + 2.146 2.042 -0.349
ENSG00000129353 E018 162.2045920 0.0010531475 3.456110e-02 8.082831e-02 19 10634756 10634887 132 + 2.201 2.162 -0.133
ENSG00000129353 E019 4.6804044 0.0034128823 2.239047e-05 1.372576e-04 19 10634888 10634973 86 + 1.016 0.462 -2.303
ENSG00000129353 E020 150.6377867 0.0002799028 9.436122e-01 9.686298e-01 19 10634974 10635069 96 + 2.121 2.152 0.101
ENSG00000129353 E021 74.2144302 0.0003646506 5.891827e-01 7.122550e-01 19 10635070 10635073 4 + 1.800 1.851 0.175
ENSG00000129353 E022 145.8515603 0.0002280929 5.768363e-01 7.022028e-01 19 10635163 10635255 93 + 2.094 2.140 0.153
ENSG00000129353 E023 7.8888191 0.0253866364 1.299535e-03 4.974902e-03 19 10635256 10635430 175 + 1.144 0.744 -1.510
ENSG00000129353 E024 140.1067513 0.0002194420 9.847737e-01 9.945434e-01 19 10635431 10635515 85 + 2.091 2.118 0.091
ENSG00000129353 E025 13.3175464 0.0318852417 2.857125e-03 9.845279e-03 19 10635804 10636322 519 + 1.324 0.992 -1.189
ENSG00000129353 E026 259.1448239 0.0007988601 5.890054e-01 7.121378e-01 19 10636323 10636585 263 + 2.346 2.390 0.145
ENSG00000129353 E027 157.0980707 0.0002426094 4.188515e-01 5.620974e-01 19 10636662 10636756 95 + 2.123 2.176 0.177
ENSG00000129353 E028 0.0000000       19 10636926 10637142 217 +      
ENSG00000129353 E029 0.0000000       19 10637532 10637561 30 +      
ENSG00000129353 E030 87.0426249 0.0003936051 3.372847e-02 7.921166e-02 19 10637644 10637649 6 + 1.821 1.938 0.395
ENSG00000129353 E031 166.0101232 0.0002138884 2.996112e-01 4.411593e-01 19 10637650 10637743 94 + 2.141 2.200 0.197
ENSG00000129353 E032 89.6022643 0.0002940481 5.607661e-01 6.887072e-01 19 10637744 10637747 4 + 1.915 1.920 0.015
ENSG00000129353 E033 176.0645483 0.0002548951 5.331804e-01 6.654201e-01 19 10637856 10637929 74 + 2.176 2.223 0.155
ENSG00000129353 E034 195.6246908 0.0002378095 2.127082e-01 3.417427e-01 19 10638023 10638093 71 + 2.211 2.274 0.209
ENSG00000129353 E035 220.1508334 0.0002203123 6.967353e-02 1.428233e-01 19 10638227 10638315 89 + 2.250 2.326 0.253
ENSG00000129353 E036 1.0642801 0.0121885815 4.191176e-02 9.456388e-02 19 10642336 10642366 31 + 0.509 0.169 -2.234
ENSG00000129353 E037 210.4471327 0.0023795268 1.381451e-01 2.455013e-01 19 10642367 10642451 85 + 2.225 2.308 0.277
ENSG00000129353 E038 4.5254843 0.0036205623 4.899721e-01 6.273316e-01 19 10642897 10643021 125 + 0.615 0.741 0.530
ENSG00000129353 E039 6.5665638 0.0339612973 1.099344e-01 2.054487e-01 19 10643022 10643278 257 + 0.616 0.902 1.159
ENSG00000129353 E040 854.7668035 0.0065365788 8.141867e-08 8.415825e-07 19 10643279 10644557 1279 + 2.730 2.953 0.742