ENSG00000129351

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407004 ENSG00000129351 HEK293_OSMI2_2hA HEK293_TMG_2hB ILF3 protein_coding protein_coding 289.4473 326.1545 267.9372 11.86516 2.480711 -0.2836513 121.19809 160.28867 98.06955 6.3385425 2.657827 -0.7087381 0.41434583 0.49170000 0.3659000 -0.125800000 9.996408e-07 1.878079e-143 FALSE TRUE
ENST00000587928 ENSG00000129351 HEK293_OSMI2_2hA HEK293_TMG_2hB ILF3 protein_coding retained_intron 289.4473 326.1545 267.9372 11.86516 2.480711 -0.2836513 18.07780 12.84996 22.05067 0.7692156 1.383151 0.7785907 0.06454167 0.03963333 0.0823000 0.042666667 2.373413e-05 1.878079e-143 TRUE TRUE
ENST00000589998 ENSG00000129351 HEK293_OSMI2_2hA HEK293_TMG_2hB ILF3 protein_coding protein_coding 289.4473 326.1545 267.9372 11.86516 2.480711 -0.2836513 37.40006 0.00000 60.50825 0.0000000 2.457581 12.5631546 0.13587917 0.00000000 0.2260000 0.226000000 1.878079e-143 1.878079e-143 FALSE TRUE
ENST00000590261 ENSG00000129351 HEK293_OSMI2_2hA HEK293_TMG_2hB ILF3 protein_coding protein_coding 289.4473 326.1545 267.9372 11.86516 2.480711 -0.2836513 15.33163 42.22439 0.00000 15.4712777 0.000000 -12.0442025 0.04896250 0.12763333 0.0000000 -0.127633333 1.515978e-18 1.878079e-143 FALSE TRUE
MSTRG.16424.8 ENSG00000129351 HEK293_OSMI2_2hA HEK293_TMG_2hB ILF3 protein_coding   289.4473 326.1545 267.9372 11.86516 2.480711 -0.2836513 31.46163 33.99896 27.39764 17.9512040 1.686574 -0.3113367 0.10822083 0.10723333 0.1021667 -0.005066667 9.225877e-01 1.878079e-143 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129351 E001 15.823038 4.304664e-02 7.102473e-01 8.074594e-01 19 10654261 10654303 43 + 1.229 1.203 -0.094
ENSG00000129351 E002 67.279385 1.258129e-02 6.620205e-02 1.370507e-01 19 10654304 10654327 24 + 1.873 1.782 -0.308
ENSG00000129351 E003 164.648491 1.024534e-02 1.420472e-01 2.508359e-01 19 10654328 10654360 33 + 2.234 2.188 -0.153
ENSG00000129351 E004 320.871185 6.608187e-03 1.874159e-03 6.835957e-03 19 10654361 10654381 21 + 2.554 2.453 -0.338
ENSG00000129351 E005 930.487527 6.507327e-03 1.739798e-05 1.094106e-04 19 10654382 10654487 106 + 3.037 2.898 -0.462
ENSG00000129351 E006 12.343281 1.430029e-03 3.076695e-01 4.498953e-01 19 10654938 10655023 86 + 1.156 1.095 -0.219
ENSG00000129351 E007 25.496931 7.395651e-03 1.261564e-02 3.500439e-02 19 10655024 10655123 100 + 1.506 1.346 -0.554
ENSG00000129351 E008 6.574187 2.878113e-02 3.106953e-01 4.531244e-01 19 10655124 10655147 24 + 0.925 0.812 -0.432
ENSG00000129351 E009 4.928662 7.919426e-03 2.616538e-01 3.993260e-01 19 10655496 10655585 90 + 0.637 0.828 0.782
ENSG00000129351 E010 17.700261 1.229272e-03 2.381117e-01 3.719455e-01 19 10666492 10666649 158 + 1.298 1.238 -0.210
ENSG00000129351 E011 2.773126 5.763197e-03 9.823991e-01 9.930431e-01 19 10670512 10670515 4 + 0.555 0.587 0.143
ENSG00000129351 E012 777.752574 4.347883e-03 1.756103e-07 1.701992e-06 19 10670516 10670536 21 + 2.963 2.818 -0.481
ENSG00000129351 E013 1256.351051 3.525436e-03 8.272443e-07 6.993260e-06 19 10670537 10670605 69 + 3.155 3.040 -0.380
ENSG00000129351 E014 831.103712 3.172197e-03 2.382770e-04 1.126129e-03 19 10670606 10670608 3 + 2.953 2.878 -0.249
ENSG00000129351 E015 2.950462 5.283374e-03 2.356712e-01 3.691621e-01 19 10670815 10670973 159 + 0.455 0.674 1.007
ENSG00000129351 E016 1367.323685 2.144718e-03 2.715848e-06 2.052946e-05 19 10670974 10671036 63 + 3.171 3.093 -0.260
ENSG00000129351 E017 1831.540992 1.400735e-03 1.131801e-10 1.980202e-09 19 10671037 10671133 97 + 3.306 3.214 -0.303
ENSG00000129351 E018 1375.752780 9.148238e-05 4.528565e-40 1.571288e-37 19 10671134 10671169 36 + 3.187 3.086 -0.337
ENSG00000129351 E019 1379.359036 9.667546e-05 2.098636e-37 6.126044e-35 19 10671170 10671203 34 + 3.186 3.089 -0.323
ENSG00000129351 E020 1959.518133 1.002418e-04 3.157003e-32 6.191354e-30 19 10671358 10671480 123 + 3.324 3.252 -0.239
ENSG00000129351 E021 1425.838777 5.887798e-05 9.382004e-16 3.554785e-14 19 10671481 10671535 55 + 3.170 3.127 -0.142
ENSG00000129351 E022 1373.590029 1.805856e-04 5.042935e-13 1.297174e-11 19 10677163 10677204 42 + 3.155 3.109 -0.152
ENSG00000129351 E023 1956.270082 5.513445e-04 5.120125e-08 5.508816e-07 19 10677205 10677310 106 + 3.304 3.265 -0.128
ENSG00000129351 E024 1437.175401 5.583687e-04 1.003238e-07 1.018162e-06 19 10678613 10678652 40 + 3.172 3.130 -0.139
ENSG00000129351 E025 1349.992580 1.879318e-03 1.590685e-04 7.876594e-04 19 10678653 10678704 52 + 3.150 3.100 -0.166
ENSG00000129351 E026 1863.054787 1.586840e-03 5.635564e-04 2.397642e-03 19 10679097 10679184 88 + 3.281 3.246 -0.116
ENSG00000129351 E027 1005.229688 1.808382e-03 8.344995e-02 1.649573e-01 19 10679185 10679192 8 + 2.994 2.990 -0.013
ENSG00000129351 E028 1668.669894 1.429217e-03 6.906309e-03 2.098208e-02 19 10679816 10679927 112 + 3.222 3.205 -0.058
ENSG00000129351 E029 1443.168276 1.841673e-04 1.630883e-06 1.293123e-05 19 10680346 10680443 98 + 3.160 3.143 -0.056
ENSG00000129351 E030 1611.310366 2.006975e-04 2.898180e-15 1.033995e-13 19 10681019 10681130 112 + 3.228 3.178 -0.166
ENSG00000129351 E031 1770.497921 1.021279e-04 2.175566e-07 2.071024e-06 19 10681219 10681329 111 + 3.246 3.234 -0.041
ENSG00000129351 E032 544.763426 2.264237e-03 5.312772e-38 1.612963e-35 19 10681330 10681992 663 + 2.894 2.568 -1.084
ENSG00000129351 E033 2760.064965 2.458511e-04 6.732753e-01 7.790026e-01 19 10681993 10682192 200 + 3.410 3.443 0.110
ENSG00000129351 E034 3151.220338 7.602656e-05 4.412595e-02 9.861540e-02 19 10682537 10682704 168 + 3.474 3.497 0.075
ENSG00000129351 E035 636.533070 3.581912e-04 1.205188e-07 1.205678e-06 19 10683125 10683136 12 + 2.825 2.774 -0.170
ENSG00000129351 E036 1329.058307 6.557478e-05 3.030256e-04 1.391827e-03 19 10683137 10683139 3 + 3.114 3.114 0.000
ENSG00000129351 E037 2753.199559 3.937333e-05 2.616333e-04 1.223269e-03 19 10683140 10683262 123 + 3.423 3.434 0.037
ENSG00000129351 E038 2465.125068 6.036923e-05 4.337219e-01 5.761275e-01 19 10683366 10683517 152 + 3.355 3.399 0.147
ENSG00000129351 E039 1244.691722 1.022132e-04 7.597001e-02 1.530639e-01 19 10683518 10683542 25 + 3.049 3.107 0.193
ENSG00000129351 E040 1729.969200 2.937453e-04 6.298343e-02 1.316811e-01 19 10683636 10683755 120 + 3.190 3.250 0.199
ENSG00000129351 E041 1132.996513 1.550750e-04 6.104195e-03 1.888374e-02 19 10683756 10683789 34 + 3.000 3.071 0.238
ENSG00000129351 E042 1354.563978 3.924475e-04 1.985090e-06 1.545329e-05 19 10683917 10683970 54 + 3.056 3.160 0.345
ENSG00000129351 E043 62.750130 3.769744e-04 3.120317e-08 3.498045e-07 19 10683971 10684415 445 + 1.908 1.699 -0.707
ENSG00000129351 E044 940.968695 4.273268e-04 2.020884e-03 7.290304e-03 19 10684416 10684476 61 + 2.910 2.996 0.287
ENSG00000129351 E045 2677.382976 7.291067e-04 6.694174e-08 7.033170e-07 19 10684477 10684858 382 + 3.342 3.460 0.392
ENSG00000129351 E046 1174.566984 3.816097e-03 1.172415e-05 7.668033e-05 19 10684859 10684921 63 + 2.941 3.122 0.600
ENSG00000129351 E047 4444.952857 5.968516e-03 4.396521e-08 4.793989e-07 19 10684922 10685765 844 + 3.474 3.717 0.807
ENSG00000129351 E048 119.190283 6.360340e-03 7.844278e-05 4.206269e-04 19 10685928 10687345 1418 + 2.159 1.994 -0.553
ENSG00000129351 E049 1103.286728 7.420329e-04 1.386139e-11 2.821679e-10 19 10687346 10687604 259 + 2.931 3.086 0.515
ENSG00000129351 E050 998.073078 1.934952e-03 2.894438e-03 9.955024e-03 19 10687605 10687708 104 + 2.917 3.028 0.367
ENSG00000129351 E051 38.834369 1.287202e-02 3.505248e-01 4.946950e-01 19 10687709 10688114 406 + 1.612 1.571 -0.140
ENSG00000129351 E052 1122.702115 2.703457e-03 2.134629e-02 5.431752e-02 19 10688550 10688678 129 + 2.975 3.076 0.338
ENSG00000129351 E053 9098.569985 2.687005e-03 1.766679e-17 8.388274e-16 19 10689179 10692417 3239 + 3.790 4.026 0.783