ENSG00000129347

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312962 ENSG00000129347 HEK293_OSMI2_2hA HEK293_TMG_2hB KRI1 protein_coding protein_coding 58.36641 69.94511 49.23472 2.007586 1.359482 -0.5064604 34.809351 56.302670 20.720239 0.8995656 1.962282 -1.441723 0.5692500 0.8057000 0.4228333 -0.3828667 3.159997e-09 8.540077e-27 FALSE TRUE
ENST00000478863 ENSG00000129347 HEK293_OSMI2_2hA HEK293_TMG_2hB KRI1 protein_coding retained_intron 58.36641 69.94511 49.23472 2.007586 1.359482 -0.5064604 11.501747 8.942834 12.545273 0.6980725 1.242681 0.487877 0.2077125 0.1275333 0.2541000 0.1265667 1.317579e-05 8.540077e-27 TRUE TRUE
MSTRG.16417.9 ENSG00000129347 HEK293_OSMI2_2hA HEK293_TMG_2hB KRI1 protein_coding   58.36641 69.94511 49.23472 2.007586 1.359482 -0.5064604 3.187176 0.000000 5.884544 0.0000000 1.157276 9.203236 0.0600750 0.0000000 0.1186000 0.1186000 8.540077e-27 8.540077e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129347 E001 2.4239094 0.0305810434 2.329710e-01 3.659581e-01 19 10553085 10553090 6 - 0.364 0.588 1.129
ENSG00000129347 E002 111.3864604 0.0004829386 4.564030e-10 7.198272e-09 19 10553091 10553212 122 - 1.833 2.084 0.845
ENSG00000129347 E003 420.0487447 0.0031319248 6.058449e-06 4.232915e-05 19 10553213 10553575 363 - 2.478 2.636 0.527
ENSG00000129347 E004 79.6160113 0.0078792934 8.347168e-05 4.444230e-04 19 10553576 10553590 15 - 1.684 1.940 0.865
ENSG00000129347 E005 98.8747074 0.0060633719 3.674563e-04 1.648231e-03 19 10553591 10553607 17 - 1.819 2.024 0.692
ENSG00000129347 E006 1227.5005560 0.0011657060 2.453922e-10 4.046729e-09 19 10553608 10554281 674 - 2.966 3.093 0.420
ENSG00000129347 E007 341.0246106 0.0001437069 4.696064e-05 2.664037e-04 19 10555087 10555130 44 - 2.434 2.526 0.307
ENSG00000129347 E008 383.3008257 0.0001382383 5.851135e-03 1.822139e-02 19 10555131 10555185 55 - 2.507 2.568 0.202
ENSG00000129347 E009 312.6808264 0.0002280200 1.628454e-01 2.788525e-01 19 10555285 10555308 24 - 2.435 2.472 0.123
ENSG00000129347 E010 327.1660273 0.0001723672 3.899383e-01 5.339779e-01 19 10555309 10555349 41 - 2.465 2.489 0.081
ENSG00000129347 E011 238.4143730 0.0003704979 7.739726e-01 8.542445e-01 19 10557552 10557557 6 - 2.338 2.351 0.045
ENSG00000129347 E012 519.1085791 0.0001504435 3.678283e-01 5.122111e-01 19 10557558 10557682 125 - 2.666 2.687 0.071
ENSG00000129347 E013 87.7666334 0.0039024310 3.538214e-03 1.183488e-02 19 10557683 10557768 86 - 2.001 1.864 -0.459
ENSG00000129347 E014 282.4970460 0.0001707871 3.144598e-02 7.477809e-02 19 10557769 10557790 22 - 2.378 2.434 0.185
ENSG00000129347 E015 423.1687693 0.0001819410 5.833339e-02 1.237718e-01 19 10557791 10557895 105 - 2.563 2.605 0.140
ENSG00000129347 E016 429.3099219 0.0001248131 2.641084e-01 4.020517e-01 19 10557972 10558060 89 - 2.581 2.607 0.088
ENSG00000129347 E017 14.6626556 0.0047299022 1.613620e-04 7.978061e-04 19 10558061 10558163 103 - 1.360 1.019 -1.216
ENSG00000129347 E018 443.2494136 0.0003658892 8.830107e-01 9.291278e-01 19 10558164 10558239 76 - 2.608 2.617 0.031
ENSG00000129347 E019 642.8300936 0.0001186080 7.660060e-01 8.486213e-01 19 10559359 10559529 171 - 2.774 2.776 0.005
ENSG00000129347 E020 14.1499787 0.0773703444 1.288773e-03 4.938891e-03 19 10559530 10559612 83 - 1.430 0.916 -1.840
ENSG00000129347 E021 450.0809593 0.0001328778 6.139230e-01 7.325176e-01 19 10559613 10559708 96 - 2.623 2.620 -0.011
ENSG00000129347 E022 2.2386347 0.5243511930 9.695523e-01 9.849626e-01 19 10559709 10559807 99 - 0.614 0.421 -0.926
ENSG00000129347 E023 1.2951885 0.0102233104 3.979138e-01 5.416576e-01 19 10559808 10559809 2 - 0.440 0.294 -0.860
ENSG00000129347 E024 430.1917117 0.0002784761 1.032986e-01 1.954967e-01 19 10559810 10559936 127 - 2.616 2.591 -0.086
ENSG00000129347 E025 21.3147907 0.0140323723 1.583632e-02 4.237192e-02 19 10560276 10560311 36 - 1.457 1.239 -0.757
ENSG00000129347 E026 346.5510441 0.0010305391 2.940192e-03 1.008803e-02 19 10560312 10560371 60 - 2.552 2.484 -0.226
ENSG00000129347 E027 234.2740483 0.0015550327 1.875824e-03 6.840996e-03 19 10560372 10560380 9 - 2.396 2.308 -0.295
ENSG00000129347 E028 389.5339506 0.0001735664 2.395842e-04 1.131572e-03 19 10560381 10560448 68 - 2.602 2.536 -0.217
ENSG00000129347 E029 415.1664504 0.0010714977 5.860909e-04 2.482242e-03 19 10561003 10561080 78 - 2.637 2.562 -0.250
ENSG00000129347 E030 365.2216726 0.0009777301 1.375572e-01 2.446838e-01 19 10561169 10561232 64 - 2.552 2.521 -0.100
ENSG00000129347 E031 333.2911320 0.0001515150 1.530131e-01 2.657706e-01 19 10561233 10561265 33 - 2.507 2.483 -0.080
ENSG00000129347 E032 361.9064119 0.0001463914 7.082120e-04 2.928615e-03 19 10561667 10561716 50 - 2.568 2.507 -0.204
ENSG00000129347 E033 2.7106593 0.0095789155 1.604953e-02 4.284557e-02 19 10561717 10561790 74 - 0.765 0.389 -1.735
ENSG00000129347 E034 358.6818725 0.0001568867 2.653924e-05 1.598963e-04 19 10561791 10561845 55 - 2.574 2.497 -0.259
ENSG00000129347 E035 432.4639291 0.0005451562 3.566495e-04 1.605902e-03 19 10562729 10562821 93 - 2.647 2.579 -0.226
ENSG00000129347 E036 206.4904071 0.0002041628 2.667044e-03 9.273749e-03 19 10562822 10562825 4 - 2.331 2.258 -0.243
ENSG00000129347 E037 217.7717692 0.0011729995 1.356025e-02 3.721496e-02 19 10562826 10562837 12 - 2.350 2.283 -0.225
ENSG00000129347 E038 361.2187112 0.0025669472 6.882078e-02 1.414180e-01 19 10564929 10565034 106 - 2.559 2.508 -0.169
ENSG00000129347 E039 32.8687366 0.0059909639 1.391967e-19 8.473781e-18 19 10565035 10565716 682 - 1.825 1.184 -2.206
ENSG00000129347 E040 257.0942219 0.0011314034 1.870497e-01 3.100291e-01 19 10565717 10565790 74 - 2.397 2.366 -0.105
ENSG00000129347 E041 0.8157519 0.0158437925 2.664467e-01 4.046296e-01 19 10565791 10565905 115 - 0.365 0.171 -1.445
ENSG00000129347 E042 203.5598510 0.0042611797 7.288520e-01 8.212183e-01 19 10565906 10566031 126 - 2.279 2.273 -0.023