ENSG00000129317

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344862 ENSG00000129317 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7L protein_coding protein_coding 4.601562 0.4177384 7.817944 0.02729665 0.2674014 4.193833 1.8608563 0.3747593 3.5163135 0.01664444 0.1618475 3.196133 0.63740000 0.90886667 0.4518000 -0.4570667 0.000376742 0.000376742 FALSE TRUE
ENST00000416848 ENSG00000129317 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7L protein_coding protein_coding 4.601562 0.4177384 7.817944 0.02729665 0.2674014 4.193833 0.7839095 0.0000000 1.1502207 0.00000000 0.2950116 6.858255 0.11723333 0.00000000 0.1497667 0.1497667 0.045512137 0.000376742 FALSE TRUE
ENST00000431332 ENSG00000129317 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7L protein_coding protein_coding 4.601562 0.4177384 7.817944 0.02729665 0.2674014 4.193833 0.5729724 0.0000000 0.8087486 0.00000000 0.2887505 6.355349 0.06894583 0.00000000 0.1015333 0.1015333 0.210008328 0.000376742 FALSE TRUE
ENST00000551923 ENSG00000129317 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7L protein_coding protein_coding 4.601562 0.4177384 7.817944 0.02729665 0.2674014 4.193833 0.7794040 0.0429791 1.7559391 0.04297910 0.2429366 5.058868 0.10769167 0.09113333 0.2239000 0.1327667 0.337105889 0.000376742 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129317 E001 435.734416 0.0002271260 4.617145e-23 4.116255e-21 12 43718992 43728606 9615 - 2.390 2.569 0.597
ENSG00000129317 E002 53.058436 0.0017585476 1.137073e-01 2.109306e-01 12 43728607 43729257 651 - 1.497 1.608 0.379
ENSG00000129317 E003 57.283891 0.0004577022 6.904078e-01 7.921058e-01 12 43729258 43729762 505 - 1.539 1.559 0.066
ENSG00000129317 E004 90.158693 0.0004172945 3.911655e-03 1.289570e-02 12 43729763 43730702 940 - 1.749 1.531 -0.739
ENSG00000129317 E005 24.138301 0.0008213180 2.853520e-03 9.833753e-03 12 43731705 43731758 54 - 1.212 0.732 -1.800
ENSG00000129317 E006 50.291913 0.0004314618 2.051890e-02 5.258363e-02 12 43736381 43736661 281 - 1.504 1.269 -0.813
ENSG00000129317 E007 18.295449 0.0011219987 3.621055e-01 5.065033e-01 12 43738310 43738332 23 - 1.082 0.939 -0.525
ENSG00000129317 E008 19.268017 0.0009648563 6.354900e-02 1.326060e-01 12 43738333 43738352 20 - 1.112 0.813 -1.119
ENSG00000129317 E009 19.444182 0.0009081272 2.665842e-01 4.048026e-01 12 43738353 43738391 39 - 1.109 0.939 -0.622
ENSG00000129317 E010 24.553203 0.0007391593 1.270123e-01 2.299776e-01 12 43742457 43742555 99 - 1.205 0.991 -0.772
ENSG00000129317 E011 24.151816 0.0010633203 1.449225e-01 2.547386e-01 12 43746046 43746213 168 - 1.197 0.991 -0.744
ENSG00000129317 E012 10.231659 0.0019688895 1.430787e-03 5.409481e-03 12 43746214 43746238 25 - 0.883 0.000 -14.087
ENSG00000129317 E013 25.423943 0.0036556991 7.253658e-05 3.923661e-04 12 43748450 43748609 160 - 1.238 0.505 -2.888
ENSG00000129317 E014 25.004287 0.0021517972 5.550141e-02 1.188423e-01 12 43754336 43754442 107 - 1.215 0.940 -1.001
ENSG00000129317 E015 48.781940 0.0018168725 6.282292e-02 1.314114e-01 12 43754443 43754866 424 - 1.487 1.295 -0.665
ENSG00000129317 E016 40.203498 0.0005438748 4.842201e-05 2.738084e-04 12 43754867 43755216 350 - 1.422 0.881 -1.946
ENSG00000129317 E017 17.073199 0.0010469894 3.496161e-03 1.171408e-02 12 43755217 43755261 45 - 1.075 0.505 -2.307
ENSG00000129317 E018 4.994691 0.0555516132 4.921344e-02 1.077618e-01 12 43758286 43758607 322 - 0.630 0.000 -13.024
ENSG00000129317 E019 1.624347 0.0443333939 4.267461e-01 5.695554e-01 12 43758608 43758692 85 - 0.314 0.000 -11.576
ENSG00000129317 E020 1.067502 0.0114775037 5.508852e-01 6.804390e-01 12 43758693 43758700 8 - 0.198 0.322 0.929
ENSG00000129317 E021 4.804970 0.0034494329 7.281627e-01 8.206955e-01 12 43758701 43758729 29 - 0.590 0.505 -0.393
ENSG00000129317 E022 11.677043 0.0014684678 5.865687e-04 2.484099e-03 12 43758730 43758793 64 - 0.935 0.000 -14.250