ENSG00000129295

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250173 ENSG00000129295 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF11 protein_coding protein_coding 0.3245443 0.3579757 0.3635886 0.09065321 0.05598374 0.02183998 0.033978263 0.05845012 0.04408823 0.03554977 0.02299471 -0.3397383 0.11460833 0.21640000 0.1133667 -0.10303333 0.848985803 0.004415255 TRUE TRUE
ENST00000519085 ENSG00000129295 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF11 protein_coding protein_coding 0.3245443 0.3579757 0.3635886 0.09065321 0.05598374 0.02183998 0.014257977 0.05130565 0.00000000 0.05130565 0.00000000 -2.6160200 0.03372083 0.09516667 0.0000000 -0.09516667 0.720881772 0.004415255 FALSE TRUE
ENST00000519595 ENSG00000129295 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF11 protein_coding protein_coding 0.3245443 0.3579757 0.3635886 0.09065321 0.05598374 0.02183998 0.075010683 0.01733546 0.18190921 0.01733546 0.09096870 2.8115784 0.23645833 0.03216667 0.5923667 0.56020000 0.389499185 0.004415255 FALSE TRUE
ENST00000521430 ENSG00000129295 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF11 protein_coding processed_transcript 0.3245443 0.3579757 0.3635886 0.09065321 0.05598374 0.02183998 0.029541170 0.07430845 0.00000000 0.07430845 0.00000000 -3.0756772 0.07748333 0.13783333 0.0000000 -0.13783333 0.716365575 0.004415255   FALSE
ENST00000522584 ENSG00000129295 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF11 protein_coding nonsense_mediated_decay 0.3245443 0.3579757 0.3635886 0.09065321 0.05598374 0.02183998 0.006231802 0.00000000 0.04985442 0.00000000 0.04985442 2.5814578 0.01332917 0.00000000 0.1066333 0.10663333 0.750782659 0.004415255   FALSE
ENST00000522597 ENSG00000129295 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF11 protein_coding retained_intron 0.3245443 0.3579757 0.3635886 0.09065321 0.05598374 0.02183998 0.027987383 0.00000000 0.08773670 0.00000000 0.08773670 3.2889004 0.06167917 0.00000000 0.1876333 0.18763333 0.782112217 0.004415255 FALSE FALSE
ENST00000523503 ENSG00000129295 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF11 protein_coding processed_transcript 0.3245443 0.3579757 0.3635886 0.09065321 0.05598374 0.02183998 0.048919491 0.11508729 0.00000000 0.01734522 0.00000000 -3.6448633 0.12549583 0.36330000 0.0000000 -0.36330000 0.004415255 0.004415255   FALSE
ENST00000620350 ENSG00000129295 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAAF11 protein_coding protein_coding 0.3245443 0.3579757 0.3635886 0.09065321 0.05598374 0.02183998 0.041237568 0.04148868 0.00000000 0.02077074 0.00000000 -2.3642554 0.24317083 0.15513333 0.0000000 -0.15513333 0.231325081 0.004415255 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129295 E001 0.6599951 0.021995016 0.02897561 0.06995822 8 132570416 132572069 1654 - 0.000 0.391 12.031
ENSG00000129295 E002 0.0000000       8 132572070 132572198 129 -      
ENSG00000129295 E003 0.0000000       8 132572199 132572200 2 -      
ENSG00000129295 E004 1.1310007 0.080385655 0.59476788 0.71694806 8 132572201 132572424 224 - 0.272 0.391 0.749
ENSG00000129295 E005 0.9911135 0.013824498 0.88230373 0.92864575 8 132572425 132572480 56 - 0.272 0.322 0.335
ENSG00000129295 E006 0.4751703 0.021768165 0.50624699 0.64190409 8 132578408 132578516 109 - 0.111 0.238 1.333
ENSG00000129295 E007 1.6177992 0.009084931 0.85136921 0.90783357 8 132583694 132583775 82 - 0.389 0.451 0.334
ENSG00000129295 E008 0.0000000       8 132583776 132583779 4 -      
ENSG00000129295 E009 0.3686942 0.029842482 0.94301393 0.96826224 8 132608405 132608553 149 - 0.111 0.136 0.338
ENSG00000129295 E010 0.8470867 0.016333796 0.75063999 0.83724754 8 132610162 132610165 4 - 0.272 0.239 -0.249
ENSG00000129295 E011 1.8382002 0.009279895 0.91616680 0.95100256 8 132610166 132610252 87 - 0.438 0.452 0.073
ENSG00000129295 E012 0.7696683 0.017129924 0.75228780 0.83855228 8 132610253 132610261 9 - 0.272 0.238 -0.251
ENSG00000129295 E013 1.6585867 0.009386925 0.17051975 0.28882719 8 132611294 132611363 70 - 0.521 0.321 -1.082
ENSG00000129295 E014 1.4027854 0.010641793 0.11808413 0.21718689 8 132615038 132615097 60 - 0.481 0.238 -1.473
ENSG00000129295 E015 1.6167419 0.010347528 0.65366788 0.76408717 8 132622611 132622688 78 - 0.438 0.391 -0.250
ENSG00000129295 E016 0.0000000       8 132622689 132622793 105 -      
ENSG00000129295 E017 0.5890081 0.020297355 0.91233940 0.94844028 8 132625272 132625311 40 - 0.199 0.238 0.331
ENSG00000129295 E018 1.2542887 0.015149526 0.38577457 0.52996167 8 132625312 132625387 76 - 0.272 0.451 1.068
ENSG00000129295 E019 1.4036260 0.161969773 0.16091564 0.27631482 8 132625388 132625454 67 - 0.198 0.541 2.096
ENSG00000129295 E020 2.4658178 0.007590856 0.77998429 0.85855374 8 132632740 132632963 224 - 0.557 0.551 -0.030
ENSG00000129295 E021 1.0340911 0.013732758 0.06381102 0.13303993 8 132637935 132637984 50 - 0.438 0.135 -2.252
ENSG00000129295 E022 1.0716670 0.016860866 0.81196699 0.88070935 8 132637985 132638051 67 - 0.334 0.321 -0.083
ENSG00000129295 E023 0.9190056 0.015836761 0.33613945 0.47995636 8 132638052 132638107 56 - 0.199 0.391 1.331
ENSG00000129295 E024 0.0000000       8 132643374 132643379 6 -      
ENSG00000129295 E025 0.0000000       8 132643380 132643414 35 -      
ENSG00000129295 E026 0.0000000       8 132643415 132643623 209 -      
ENSG00000129295 E027 0.0000000       8 132643624 132643686 63 -      
ENSG00000129295 E028 0.6224193 0.018669113 0.90675506 0.94477611 8 132656830 132656907 78 - 0.199 0.238 0.333
ENSG00000129295 E029 1.3954236 0.156933102 0.48775552 0.62540233 8 132661460 132661627 168 - 0.437 0.320 -0.671
ENSG00000129295 E030 0.4428904 0.530759256 0.30159672 0.44341430 8 132675274 132675317 44 - 0.000 0.249 11.125
ENSG00000129295 E031 0.8460400 0.303221681 0.06427289 0.13382469 8 132675318 132675483 166 - 0.000 0.405 12.114
ENSG00000129295 E032 1.2481600 0.085064710 0.60012795 0.72142162 8 132675484 132675525 42 - 0.272 0.395 0.769
ENSG00000129295 E033 1.3588773 0.012756722 0.58922212 0.71228440 8 132675526 132675545 20 - 0.389 0.322 -0.399
ENSG00000129295 E034 0.6590396 0.019387492 0.37211611 0.51658494 8 132675546 132675558 13 - 0.272 0.135 -1.248
ENSG00000129295 E035 0.5138669 0.021768165 0.63901584 0.75251211 8 132675559 132675559 1 - 0.199 0.135 -0.663
ENSG00000129295 E036 0.5138669 0.021768165 0.63901584 0.75251211 8 132675560 132675580 21 - 0.199 0.135 -0.663
ENSG00000129295 E037 0.5138669 0.021768165 0.63901584 0.75251211 8 132675581 132675592 12 - 0.199 0.135 -0.663