ENSG00000129292

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220847 ENSG00000129292 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF20L1 protein_coding protein_coding 12.69179 2.810269 22.12301 0.1546422 0.5006829 2.972295 2.3394278 0.0000000 5.7904444 0.00000000 0.45647359 9.180020 0.16967917 0.00000000 0.26136667 0.26136667 6.627672e-17 6.627672e-17 FALSE TRUE
ENST00000337920 ENSG00000129292 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF20L1 protein_coding protein_coding 12.69179 2.810269 22.12301 0.1546422 0.5006829 2.972295 1.6872144 0.5434604 3.0772112 0.08017525 0.08251362 2.479752 0.13013750 0.19310000 0.13936667 -0.05373333 3.213176e-01 6.627672e-17 FALSE TRUE
ENST00000395386 ENSG00000129292 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF20L1 protein_coding protein_coding 12.69179 2.810269 22.12301 0.1546422 0.5006829 2.972295 0.2243751 0.1726022 0.0000000 0.17260220 0.00000000 -4.190632 0.02153750 0.06543333 0.00000000 -0.06543333 4.447856e-01 6.627672e-17 FALSE TRUE
ENST00000395390 ENSG00000129292 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF20L1 protein_coding protein_coding 12.69179 2.810269 22.12301 0.1546422 0.5006829 2.972295 3.0335500 1.0399611 5.0095311 0.39322277 1.04696017 2.257217 0.28810417 0.36093333 0.22536667 -0.13556667 6.975458e-01 6.627672e-17 FALSE TRUE
ENST00000522253 ENSG00000129292 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF20L1 protein_coding retained_intron 12.69179 2.810269 22.12301 0.1546422 0.5006829 2.972295 1.1084551 0.0000000 1.5763996 0.00000000 0.80380326 7.309612 0.04938750 0.00000000 0.07040000 0.07040000 4.582470e-01 6.627672e-17 FALSE FALSE
MSTRG.32112.10 ENSG00000129292 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF20L1 protein_coding   12.69179 2.810269 22.12301 0.1546422 0.5006829 2.972295 1.1771379 0.7301833 0.2934142 0.28581835 0.29341425 -1.286594 0.10758333 0.26413333 0.01370000 -0.25043333 2.924196e-02 6.627672e-17 FALSE TRUE
MSTRG.32112.4 ENSG00000129292 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF20L1 protein_coding   12.69179 2.810269 22.12301 0.1546422 0.5006829 2.972295 0.3568451 0.0000000 1.1126064 0.00000000 0.61999041 6.810708 0.01689167 0.00000000 0.05126667 0.05126667 5.007515e-01 6.627672e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129292 E001 1.6389949 0.0657701561 1.785885e-01 2.993858e-01 8 132775358 132775371 14 + 0.379 0.000 -12.511
ENSG00000129292 E002 1.9293403 0.0072505456 1.117707e-01 2.081596e-01 8 132775372 132775374 3 + 0.422 0.000 -15.106
ENSG00000129292 E003 4.7317931 0.0033162629 5.119247e-03 1.625398e-02 8 132775375 132775387 13 + 0.703 0.000 -16.188
ENSG00000129292 E004 6.2003582 0.0026907686 1.115870e-03 4.356597e-03 8 132775388 132775397 10 + 0.800 0.000 -16.476
ENSG00000129292 E005 6.4948562 0.0026140766 8.246872e-04 3.347500e-03 8 132775398 132775399 2 + 0.817 0.000 -16.524
ENSG00000129292 E006 7.5469314 0.0021392812 2.869559e-04 1.326993e-03 8 132775400 132775407 8 + 0.872 0.000 -16.674
ENSG00000129292 E007 26.4913138 0.0020645283 1.318483e-04 6.669765e-04 8 132775408 132775579 172 + 1.352 0.887 -1.680
ENSG00000129292 E008 28.9198809 0.0007037404 1.985666e-02 5.118700e-02 8 132775580 132775645 66 + 1.369 1.133 -0.831
ENSG00000129292 E009 0.4438354 0.1585711382 4.574985e-02 1.015795e-01 8 132777789 132777791 3 + 0.052 0.423 3.706
ENSG00000129292 E010 8.6841480 0.0020839064 1.284958e-01 2.320627e-01 8 132777792 132777795 4 + 0.893 0.639 -1.025
ENSG00000129292 E011 26.7474381 0.0007033569 4.936047e-02 1.080226e-01 8 132777796 132777822 27 + 1.334 1.133 -0.712
ENSG00000129292 E012 57.6937589 0.0008629037 6.757974e-01 7.809525e-01 8 132777823 132777911 89 + 1.633 1.606 -0.090
ENSG00000129292 E013 0.4482035 0.0261690621 1.000000e+00 1.000000e+00 8 132788804 132788999 196 + 0.140 0.000 -12.921
ENSG00000129292 E014 113.1750189 0.0002745844 1.772633e-02 4.654333e-02 8 132794410 132794581 172 + 1.932 1.817 -0.389
ENSG00000129292 E015 79.1088591 0.0024979548 9.268215e-02 1.793188e-01 8 132794733 132794817 85 + 1.777 1.674 -0.351
ENSG00000129292 E016 79.2643693 0.0009154106 4.254935e-01 5.684418e-01 8 132798772 132798860 89 + 1.769 1.724 -0.151
ENSG00000129292 E017 2.5624799 0.1265074360 9.735799e-02 1.864385e-01 8 132798861 132799082 222 + 0.379 0.717 1.595
ENSG00000129292 E018 3.0185994 0.0065114349 6.704713e-01 7.768875e-01 8 132799083 132799094 12 + 0.515 0.428 -0.440
ENSG00000129292 E019 8.1104879 0.0021084891 2.447330e-01 3.797365e-01 8 132799095 132799158 64 + 0.808 0.972 0.626
ENSG00000129292 E020 4.9362203 0.0031922755 7.368584e-02 1.494296e-01 8 132799159 132799172 14 + 0.606 0.887 1.145
ENSG00000129292 E021 4.0063123 0.0947241313 1.882949e-03 6.862093e-03 8 132799173 132799960 788 + 0.442 1.034 2.475
ENSG00000129292 E022 0.3729606 0.0293733163 1.723796e-01 2.913039e-01 8 132803541 132803818 278 + 0.052 0.265 2.733
ENSG00000129292 E023 137.1970688 0.0019729823 3.023704e-01 4.442380e-01 8 132803819 132804032 214 + 2.006 1.958 -0.160
ENSG00000129292 E024 0.8921407 0.0130268876 4.458247e-01 5.873691e-01 8 132804581 132804611 31 + 0.245 0.000 -14.034
ENSG00000129292 E025 17.7009015 0.0009941998 3.771845e-03 1.250201e-02 8 132804612 132804614 3 + 1.180 0.780 -1.492
ENSG00000129292 E026 113.6933508 0.0002838195 1.151698e-01 2.130969e-01 8 132804615 132804740 126 + 1.928 1.854 -0.250
ENSG00000129292 E027 9.1146921 0.0267143338 6.517144e-02 1.353223e-01 8 132806381 132807722 1342 + 0.834 1.101 0.998
ENSG00000129292 E028 2.3563376 0.0091428145 9.401176e-01 9.663853e-01 8 132807723 132807783 61 + 0.442 0.427 -0.079
ENSG00000129292 E029 2.9538665 0.0049319896 6.680539e-01 7.751361e-01 8 132807784 132811045 3262 + 0.515 0.427 -0.441
ENSG00000129292 E030 79.3413379 0.0010166467 7.797048e-02 1.562189e-01 8 132811046 132811128 83 + 1.747 1.844 0.327
ENSG00000129292 E031 116.0642494 0.0181597190 8.074169e-01 8.776585e-01 8 132811129 132813188 2060 + 1.925 1.951 0.086
ENSG00000129292 E032 104.3549373 0.0006781349 2.054243e-01 3.329424e-01 8 132814637 132814889 253 + 1.872 1.933 0.207
ENSG00000129292 E033 19.6138061 0.0009736643 2.344226e-02 5.866432e-02 8 132814890 132816783 1894 + 1.212 0.932 -1.019
ENSG00000129292 E034 4.3359127 0.0647182950 7.489327e-01 8.360274e-01 8 132816784 132816887 104 + 0.619 0.549 -0.317
ENSG00000129292 E035 88.4131464 0.0003080060 4.023724e-01 5.460984e-01 8 132816888 132817076 189 + 1.819 1.776 -0.146
ENSG00000129292 E036 0.4482035 0.0261690621 1.000000e+00 1.000000e+00 8 132817077 132817338 262 + 0.140 0.000 -12.921
ENSG00000129292 E037 53.9026207 0.0005595636 6.792765e-01 7.835057e-01 8 132817339 132817407 69 + 1.605 1.578 -0.091
ENSG00000129292 E038 73.8491625 0.0126213746 6.309601e-01 7.460725e-01 8 132817408 132817545 138 + 1.739 1.699 -0.137
ENSG00000129292 E039 2.3924194 0.1051135487 9.947673e-02 1.896782e-01 8 132817546 132818970 1425 + 0.481 0.000 -14.739
ENSG00000129292 E040 49.5790946 0.0139763843 3.967693e-01 5.405307e-01 8 132824004 132824060 57 + 1.578 1.494 -0.285
ENSG00000129292 E041 4.3462687 0.0178669513 4.859368e-01 6.237627e-01 8 132824061 132825034 974 + 0.592 0.716 0.532
ENSG00000129292 E042 2.7335526 0.0055009134 2.933643e-01 4.344062e-01 8 132825035 132825157 123 + 0.498 0.264 -1.357
ENSG00000129292 E043 0.5891098 0.0182846191 7.869341e-01 8.635702e-01 8 132825158 132825263 106 + 0.178 0.000 -13.414
ENSG00000129292 E044 54.1348907 0.0205599560 9.686044e-01 9.843532e-01 8 132825264 132825371 108 + 1.606 1.596 -0.033
ENSG00000129292 E045 78.7780523 0.0006999849 5.801323e-01 7.049588e-01 8 132832235 132832399 165 + 1.768 1.738 -0.103
ENSG00000129292 E046 1.0414660 0.0126942288 3.549480e-01 4.992936e-01 8 132836345 132836539 195 + 0.275 0.000 -14.241
ENSG00000129292 E047 91.5791496 0.0016043357 1.193151e-03 4.617749e-03 8 132836540 132836721 182 + 1.851 1.658 -0.653
ENSG00000129292 E048 65.2319295 0.0004220378 4.831620e-03 1.546280e-02 8 132837712 132837811 100 + 1.706 1.517 -0.644
ENSG00000129292 E049 0.1817044 0.0402777702 5.290371e-02   8 132837812 132837816 5 + 0.000 0.265 13.600
ENSG00000129292 E050 81.0416056 0.0003906351 4.132048e-02 9.347026e-02 8 132839387 132839582 196 + 1.791 1.673 -0.399
ENSG00000129292 E051 2.2732830 0.1590612119 5.431102e-01 6.737558e-01 8 132841553 132842514 962 + 0.443 0.265 -1.081
ENSG00000129292 E052 123.3843825 0.0018999246 4.926020e-01 6.297457e-01 8 132842515 132842875 361 + 1.958 1.925 -0.110
ENSG00000129292 E053 76.4835557 0.0022771547 4.550755e-01 5.956383e-01 8 132844156 132844318 163 + 1.755 1.711 -0.150
ENSG00000129292 E054 418.6868404 0.0006602922 3.018883e-26 3.670850e-24 8 132845781 132848807 3027 + 2.436 2.669 0.777