ENSG00000129250

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320785 ENSG00000129250 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF1C protein_coding protein_coding 65.50937 110.5839 40.96247 6.104555 1.27976 -1.432546 7.331736 8.458911 6.840746 0.3207419 0.2262660 -0.3059153 0.12890417 0.07666667 0.1674000 0.09073333 1.484990e-12 1.48499e-12 FALSE  
ENST00000573815 ENSG00000129250 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF1C protein_coding processed_transcript 65.50937 110.5839 40.96247 6.104555 1.27976 -1.432546 6.163926 15.961976 1.265764 1.6336617 0.6348838 -3.6461093 0.07641667 0.14360000 0.0300000 -0.11360000 2.851334e-01 1.48499e-12 FALSE  
MSTRG.13487.1 ENSG00000129250 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF1C protein_coding   65.50937 110.5839 40.96247 6.104555 1.27976 -1.432546 4.028924 6.533774 4.197038 0.6284035 0.3804446 -0.6373182 0.06625000 0.05953333 0.1030667 0.04353333 5.994961e-02 1.48499e-12 FALSE  
MSTRG.13487.2 ENSG00000129250 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF1C protein_coding   65.50937 110.5839 40.96247 6.104555 1.27976 -1.432546 47.580838 79.038453 28.277628 4.2144947 1.2201694 -1.4825660 0.72131667 0.71493333 0.6901333 -0.02480000 6.360669e-01 1.48499e-12 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129250 E001 3.1939742 4.166057e-02 9.811723e-07 8.153353e-06 17 4997935 4997949 15 + 1.015 0.207 -3.937
ENSG00000129250 E002 3.8354998 4.246978e-03 1.736717e-15 6.367636e-14 17 4997950 4997953 4 + 1.162 0.000 -16.814
ENSG00000129250 E003 254.2784691 1.167802e-02 5.852085e-03 1.822356e-02 17 4997954 4998156 203 + 2.448 2.298 -0.500
ENSG00000129250 E004 18.0108732 2.996532e-03 1.287431e-02 3.562195e-02 17 4999013 4999046 34 + 1.359 1.147 -0.747
ENSG00000129250 E005 378.3275159 5.003915e-03 5.329605e-03 1.682824e-02 17 4999850 4999970 121 + 2.587 2.485 -0.342
ENSG00000129250 E006 554.6881528 3.158272e-03 1.565105e-03 5.846370e-03 17 5000220 5000352 133 + 2.745 2.654 -0.305
ENSG00000129250 E007 510.8939366 8.464255e-04 3.334212e-10 5.383667e-09 17 5000772 5000848 77 + 2.736 2.605 -0.435
ENSG00000129250 E008 706.4891982 1.737839e-03 7.002467e-10 1.070008e-08 17 5001222 5001401 180 + 2.885 2.743 -0.474
ENSG00000129250 E009 352.4591521 2.278439e-03 6.941995e-07 5.965166e-06 17 5002059 5002124 66 + 2.585 2.440 -0.483
ENSG00000129250 E010 670.7387710 1.371430e-03 1.372999e-06 1.106806e-05 17 5002464 5002642 179 + 2.835 2.731 -0.344
ENSG00000129250 E011 613.0978157 1.478106e-03 1.333639e-02 3.670429e-02 17 5002731 5002842 112 + 2.759 2.707 -0.175
ENSG00000129250 E012 524.5660555 1.055579e-03 3.068487e-03 1.046831e-02 17 5003612 5003689 78 + 2.698 2.636 -0.205
ENSG00000129250 E013 515.7016601 4.759393e-04 7.385567e-04 3.037653e-03 17 5003851 5003916 66 + 2.691 2.629 -0.207
ENSG00000129250 E014 524.9382096 1.779940e-04 8.551593e-03 2.516893e-02 17 5003998 5004073 76 + 2.685 2.642 -0.143
ENSG00000129250 E015 529.6085267 1.708251e-04 6.663684e-02 1.377927e-01 17 5004567 5004645 79 + 2.677 2.649 -0.095
ENSG00000129250 E016 711.0136549 1.154800e-04 9.599732e-01 9.788531e-01 17 5004855 5005000 146 + 2.780 2.786 0.018
ENSG00000129250 E017 971.0919372 1.199076e-04 3.044554e-01 4.464599e-01 17 5006915 5007084 170 + 2.904 2.923 0.063
ENSG00000129250 E018 780.5324347 7.120347e-04 5.485580e-02 1.177479e-01 17 5007263 5007342 80 + 2.792 2.835 0.143
ENSG00000129250 E019 2.5506336 6.716269e-03 9.180760e-01 9.522301e-01 17 5007465 5007466 2 + 0.489 0.510 0.103
ENSG00000129250 E020 725.2837994 2.057213e-04 2.653458e-05 1.598733e-04 17 5007467 5007542 76 + 2.735 2.809 0.248
ENSG00000129250 E021 6.7118423 1.954876e-02 1.130214e-01 2.099524e-01 17 5011563 5012074 512 + 0.970 0.757 -0.823
ENSG00000129250 E022 714.8803018 1.150738e-04 2.297196e-01 3.621209e-01 17 5013653 5013732 80 + 2.769 2.793 0.078
ENSG00000129250 E023 0.1817044 3.964886e-02 1.000000e+00   17 5014194 5014306 113 + 0.000 0.080 8.365
ENSG00000129250 E024 816.7574523 9.060966e-05 5.637023e-01 6.911449e-01 17 5014743 5014837 95 + 2.847 2.844 -0.012
ENSG00000129250 E025 786.5025288 4.707233e-04 5.028701e-01 6.388715e-01 17 5019996 5020079 84 + 2.834 2.828 -0.020
ENSG00000129250 E026 1120.8899411 7.247513e-04 1.052687e-02 3.003956e-02 17 5020492 5020678 187 + 2.944 2.995 0.168
ENSG00000129250 E027 644.0230678 1.379142e-04 4.065275e-09 5.383435e-08 17 5020806 5020878 73 + 2.658 2.763 0.352
ENSG00000129250 E028 1879.4124155 9.184622e-05 1.068753e-33 2.379225e-31 17 5022092 5022709 618 + 3.104 3.234 0.430
ENSG00000129250 E029 2830.9396163 2.829713e-03 3.978018e-12 8.839123e-11 17 5023468 5025151 1684 + 3.246 3.423 0.589
ENSG00000129250 E030 679.9265546 1.041313e-03 3.902085e-36 1.025296e-33 17 5025152 5028401 3250 + 2.943 2.690 -0.842
ENSG00000129250 E031 0.8115846 5.453884e-01 1.000000e+00 1.000000e+00 17 5030708 5030745 38 + 0.182 0.220 0.345