ENSG00000129219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263088 ENSG00000129219 HEK293_OSMI2_2hA HEK293_TMG_2hB PLD2 protein_coding protein_coding 12.89546 15.97018 9.471204 0.8509769 0.8399527 -0.7531417 6.5226197 9.5314599 4.5767917 0.88366779 0.26727916 -1.0567246 0.50438750 0.59993333 0.49116667 -0.10876667 0.5556499295 0.0001036158 FALSE TRUE
ENST00000571273 ENSG00000129219 HEK293_OSMI2_2hA HEK293_TMG_2hB PLD2 protein_coding retained_intron 12.89546 15.97018 9.471204 0.8509769 0.8399527 -0.7531417 0.8336470 0.5424341 0.8592738 0.11079495 0.10729052 0.6540082 0.06729167 0.03443333 0.09096667 0.05653333 0.0081426724 0.0001036158   FALSE
ENST00000572127 ENSG00000129219 HEK293_OSMI2_2hA HEK293_TMG_2hB PLD2 protein_coding retained_intron 12.89546 15.97018 9.471204 0.8509769 0.8399527 -0.7531417 1.0801533 0.5400312 0.9263208 0.09932187 0.26091627 0.7674894 0.08800833 0.03433333 0.09463333 0.06030000 0.0292065180 0.0001036158   FALSE
ENST00000572940 ENSG00000129219 HEK293_OSMI2_2hA HEK293_TMG_2hB PLD2 protein_coding protein_coding 12.89546 15.97018 9.471204 0.8509769 0.8399527 -0.7531417 1.0421225 2.4413369 0.2980570 0.48201624 0.08370509 -2.9922996 0.07384167 0.15120000 0.03276667 -0.11843333 0.0004198507 0.0001036158 FALSE TRUE
ENST00000575945 ENSG00000129219 HEK293_OSMI2_2hA HEK293_TMG_2hB PLD2 protein_coding retained_intron 12.89546 15.97018 9.471204 0.8509769 0.8399527 -0.7531417 0.9569297 0.9382738 0.2253688 0.74548216 0.12013294 -2.0103804 0.06557500 0.06193333 0.02293333 -0.03900000 0.9655192103 0.0001036158   FALSE
ENST00000576329 ENSG00000129219 HEK293_OSMI2_2hA HEK293_TMG_2hB PLD2 protein_coding retained_intron 12.89546 15.97018 9.471204 0.8509769 0.8399527 -0.7531417 0.3456163 0.2142889 0.6682081 0.11119124 0.26773248 1.5963697 0.02795417 0.01313333 0.06700000 0.05386667 0.1742810409 0.0001036158   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129219 E001 1.7316475 0.0082962121 0.5321939249 0.6645609966 17 4807152 4807168 17 + 0.306 0.425 0.701
ENSG00000129219 E002 5.4549868 0.0031028966 0.5667041856 0.6936307316 17 4807169 4807182 14 + 0.821 0.745 -0.300
ENSG00000129219 E003 6.6696469 0.0025228187 0.8575171804 0.9120227777 17 4807183 4807191 9 + 0.853 0.833 -0.077
ENSG00000129219 E004 26.2484283 0.0007835439 0.3155130937 0.4582861099 17 4807192 4807225 34 + 1.424 1.354 -0.242
ENSG00000129219 E005 0.1472490 0.0421528229 0.1941770497   17 4807562 4807587 26 + 0.179 0.000 -10.217
ENSG00000129219 E006 53.3210272 0.0005323693 0.0050232966 0.0159952879 17 4807772 4807881 110 + 1.776 1.637 -0.472
ENSG00000129219 E007 69.1536413 0.0004127333 0.0088826100 0.0259861300 17 4807984 4808114 131 + 1.866 1.751 -0.388
ENSG00000129219 E008 2.5808887 0.0069053490 0.0011378637 0.0044300219 17 4808115 4808273 159 + 0.820 0.309 -2.435
ENSG00000129219 E009 78.0629262 0.0028439070 0.0335093185 0.0787935640 17 4808274 4808416 143 + 1.906 1.808 -0.332
ENSG00000129219 E010 0.3686942 0.0283431513 0.5083046601 0.6437467774 17 4808417 4808451 35 + 0.179 0.082 -1.296
ENSG00000129219 E011 68.2530162 0.0004485417 0.8229463790 0.8883864943 17 4809100 4809205 106 + 1.765 1.779 0.049
ENSG00000129219 E012 59.5052118 0.0016682726 0.3159305504 0.4587105587 17 4809298 4809363 66 + 1.672 1.731 0.201
ENSG00000129219 E013 60.6119476 0.0048299929 0.1422123452 0.2510572079 17 4809493 4809551 59 + 1.652 1.748 0.325
ENSG00000129219 E014 74.6971645 0.0004786026 0.2387136846 0.3726553616 17 4809691 4809783 93 + 1.772 1.831 0.199
ENSG00000129219 E015 74.4504236 0.0005423134 0.3167389247 0.4595426347 17 4809877 4810029 153 + 1.848 1.807 -0.138
ENSG00000129219 E016 24.6982728 0.0082241067 0.3471857286 0.4913661846 17 4810802 4810806 5 + 1.406 1.330 -0.266
ENSG00000129219 E017 67.0693401 0.0004148885 0.6355038580 0.7497932328 17 4810807 4810951 145 + 1.780 1.761 -0.063
ENSG00000129219 E018 0.9598804 0.0138014507 0.0060546328 0.0187536913 17 4814150 4814366 217 + 0.551 0.082 -3.619
ENSG00000129219 E019 3.8093828 0.0042093159 0.0000262606 0.0001583989 17 4814367 4814417 51 + 0.986 0.390 -2.579
ENSG00000129219 E020 44.3073114 0.0049480425 0.0416353384 0.0940668076 17 4814418 4814501 84 + 1.681 1.555 -0.430
ENSG00000129219 E021 41.4104627 0.0005530490 0.0136838097 0.0375019051 17 4814633 4814711 79 + 1.667 1.529 -0.471
ENSG00000129219 E022 53.5190924 0.0005189318 0.4628287662 0.6026842718 17 4815476 4815586 111 + 1.703 1.669 -0.118
ENSG00000129219 E023 48.3184237 0.0004886495 0.0920016908 0.1782352240 17 4815764 4815858 95 + 1.695 1.607 -0.299
ENSG00000129219 E024 39.8081179 0.0024181949 0.5929750652 0.7154379227 17 4815859 4815902 44 + 1.565 1.535 -0.102
ENSG00000129219 E025 36.6415120 0.0042573456 0.2223038228 0.3531599357 17 4815903 4815934 32 + 1.565 1.486 -0.271
ENSG00000129219 E026 57.5330232 0.0060807164 0.2111667812 0.3398888123 17 4816620 4816707 88 + 1.753 1.681 -0.246
ENSG00000129219 E027 43.3971962 0.0119726542 0.2961415164 0.4373318928 17 4816708 4816746 39 + 1.637 1.561 -0.261
ENSG00000129219 E028 4.1027324 0.0045486077 0.0051625751 0.0163706940 17 4816747 4816936 190 + 0.911 0.516 -1.646
ENSG00000129219 E029 64.4902235 0.0003908192 0.4827169718 0.6208386429 17 4816937 4817055 119 + 1.721 1.759 0.131
ENSG00000129219 E030 5.8530162 0.0029475060 0.0360534400 0.0836872189 17 4817056 4817137 82 + 0.962 0.694 -1.050
ENSG00000129219 E031 76.9900177 0.0003842572 0.3144886999 0.4571987502 17 4817146 4817259 114 + 1.791 1.841 0.169
ENSG00000129219 E032 1.6522414 0.0126917668 0.4532713701 0.5940128124 17 4817260 4817375 116 + 0.483 0.351 -0.714
ENSG00000129219 E033 1.3692855 0.0108030038 0.0970339507 0.1859420700 17 4817944 4818001 58 + 0.551 0.262 -1.624
ENSG00000129219 E034 78.9460193 0.0035134651 0.5627311291 0.6902901742 17 4818002 4818106 105 + 1.863 1.838 -0.084
ENSG00000129219 E035 8.8291807 0.1202393295 0.0013930104 0.0052841624 17 4818107 4818197 91 + 1.276 0.694 -2.182
ENSG00000129219 E036 10.1724273 0.1337182595 0.0086322196 0.0253673299 17 4818198 4818296 99 + 1.299 0.793 -1.863
ENSG00000129219 E037 74.7705310 0.0023374632 0.2751443060 0.4144062659 17 4818297 4818385 89 + 1.857 1.808 -0.166
ENSG00000129219 E038 6.6459446 0.0527213256 0.0002766873 0.0012848075 17 4818386 4818493 108 + 1.170 0.595 -2.231
ENSG00000129219 E039 85.9985272 0.0046508722 0.4034318799 0.5472121518 17 4818494 4818592 99 + 1.841 1.889 0.163
ENSG00000129219 E040 48.6600356 0.0005101207 0.1042767650 0.1970015388 17 4818593 4818607 15 + 1.559 1.657 0.334
ENSG00000129219 E041 63.9487778 0.0060056791 0.0702306170 0.1437443788 17 4818774 4818823 50 + 1.662 1.778 0.394
ENSG00000129219 E042 104.5595873 0.0018403280 0.0041179469 0.0134735615 17 4819084 4819218 135 + 1.857 1.990 0.447
ENSG00000129219 E043 92.8706371 0.0008738098 0.0069731501 0.0211532619 17 4819429 4819549 121 + 1.808 1.933 0.419
ENSG00000129219 E044 39.4272989 0.0012677111 0.6701143711 0.7766616274 17 4819550 4819582 33 + 1.514 1.545 0.107
ENSG00000129219 E045 3.3976081 0.0051553463 0.1730768487 0.2921892188 17 4821640 4821792 153 + 0.748 0.542 -0.885
ENSG00000129219 E046 90.2248641 0.0003175294 0.0644287736 0.1340873554 17 4821793 4821907 115 + 1.832 1.915 0.279
ENSG00000129219 E047 93.0051519 0.0003618147 0.0014811181 0.0055760691 17 4822640 4822720 81 + 1.798 1.939 0.476
ENSG00000129219 E048 221.8615430 0.0110736120 0.0117110357 0.0328429606 17 4822721 4823258 538 + 2.169 2.319 0.501
ENSG00000129219 E049 61.1443928 0.0132090808 0.3844409656 0.5285819140 17 4823259 4823434 176 + 1.676 1.750 0.251