ENSG00000129197

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381209 ENSG00000129197 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAIN protein_coding protein_coding 57.76597 59.9989 62.56016 6.324795 1.755687 0.06029819 21.933058 22.638505 24.344669 4.8738786 1.9702970 0.1047826 0.37325000 0.36913333 0.39036667 0.02123333 9.096569e-01 1.954722e-06 FALSE  
ENST00000536255 ENSG00000129197 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAIN protein_coding protein_coding 57.76597 59.9989 62.56016 6.324795 1.755687 0.06029819 10.383997 13.839898 9.054531 1.7347117 0.4741933 -0.6115710 0.18085417 0.23010000 0.14453333 -0.08556667 1.954722e-06 1.954722e-06 FALSE  
ENST00000572174 ENSG00000129197 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAIN protein_coding retained_intron 57.76597 59.9989 62.56016 6.324795 1.755687 0.06029819 12.027820 9.909862 15.627241 1.6458521 1.8687366 0.6565940 0.20849167 0.17380000 0.24906667 0.07526667 4.906708e-01 1.954722e-06 FALSE  
ENST00000573577 ENSG00000129197 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAIN protein_coding nonsense_mediated_decay 57.76597 59.9989 62.56016 6.324795 1.755687 0.06029819 3.747052 4.687737 3.631983 0.6315197 0.3605365 -0.3672415 0.06530000 0.07830000 0.05783333 -0.02046667 2.693322e-01 1.954722e-06 TRUE  
ENST00000575112 ENSG00000129197 HEK293_OSMI2_2hA HEK293_TMG_2hB RPAIN protein_coding nonsense_mediated_decay 57.76597 59.9989 62.56016 6.324795 1.755687 0.06029819 2.952424 1.966501 2.414536 0.2788637 0.2334711 0.2947602 0.05445417 0.03286667 0.03886667 0.00600000 7.484948e-01 1.954722e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129197 E001 6.293657 0.0027143254 9.312259e-01 9.606833e-01 17 5419641 5419887 247 + 0.872 0.858 -0.052
ENSG00000129197 E002 28.134882 0.0007837843 6.320028e-01 7.469418e-01 17 5419888 5420166 279 + 1.445 1.473 0.097
ENSG00000129197 E003 41.844499 0.0011497559 7.239314e-01 8.176290e-01 17 5420167 5420181 15 + 1.621 1.636 0.052
ENSG00000129197 E004 51.758669 0.0047674579 6.523000e-01 7.630096e-01 17 5420182 5420184 3 + 1.708 1.724 0.053
ENSG00000129197 E005 59.473829 0.0008549317 1.614907e-01 2.770477e-01 17 5420185 5420188 4 + 1.741 1.802 0.208
ENSG00000129197 E006 131.262823 0.0036823406 6.151559e-03 1.901040e-02 17 5420189 5420199 11 + 2.186 2.058 -0.427
ENSG00000129197 E007 149.130875 0.0036959519 4.759708e-02 1.049039e-01 17 5420200 5420201 2 + 2.223 2.129 -0.312
ENSG00000129197 E008 462.596002 0.0021221771 9.087241e-01 9.460212e-01 17 5420202 5420291 90 + 2.666 2.656 -0.035
ENSG00000129197 E009 860.207714 0.0001164839 1.780487e-04 8.697020e-04 17 5421296 5421466 171 + 2.910 2.949 0.128
ENSG00000129197 E010 1.661806 0.0086654894 7.793051e-01 8.580554e-01 17 5421467 5421924 458 + 0.445 0.395 -0.273
ENSG00000129197 E011 536.861148 0.0008776008 2.764356e-05 1.658010e-04 17 5422769 5422829 61 + 2.682 2.758 0.252
ENSG00000129197 E012 20.991856 0.0053561214 1.184371e-08 1.440520e-07 17 5422830 5423069 240 + 1.557 1.077 -1.679
ENSG00000129197 E013 203.005692 0.0060537879 5.364450e-01 6.682046e-01 17 5425971 5426082 112 + 2.323 2.296 -0.088
ENSG00000129197 E014 42.257939 0.0076673582 5.992929e-04 2.530631e-03 17 5426083 5426235 153 + 1.757 1.511 -0.838
ENSG00000129197 E015 256.252774 0.0018952214 2.541626e-01 3.908022e-01 17 5426236 5426299 64 + 2.430 2.395 -0.118
ENSG00000129197 E016 105.507176 0.0020680174 1.714898e-06 1.353563e-05 17 5426300 5428070 1771 + 2.129 1.928 -0.673
ENSG00000129197 E017 218.399202 0.0037239685 3.348319e-02 7.873800e-02 17 5428071 5428211 141 + 2.385 2.305 -0.268
ENSG00000129197 E018 193.237275 0.0114157213 1.153023e-02 3.241865e-02 17 5428212 5431484 3273 + 2.369 2.210 -0.530
ENSG00000129197 E019 499.578260 0.0011500400 2.593513e-04 1.214103e-03 17 5432542 5432877 336 + 2.653 2.726 0.243