ENSG00000129187

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357067 ENSG00000129187 HEK293_OSMI2_2hA HEK293_TMG_2hB DCTD protein_coding protein_coding 30.61716 35.58777 29.90871 2.899414 0.409835 -0.2507387 15.462949 17.097574 14.964845 1.4696152 0.4479020 -0.1920941 0.50399167 0.48010000 0.50096667 0.02086667 0.795769988 1.219074e-10 FALSE TRUE
ENST00000438320 ENSG00000129187 HEK293_OSMI2_2hA HEK293_TMG_2hB DCTD protein_coding protein_coding 30.61716 35.58777 29.90871 2.899414 0.409835 -0.2507387 6.418299 10.746234 5.454711 1.5289294 0.3823871 -0.9769561 0.20747917 0.29893333 0.18220000 -0.11673333 0.002534855 1.219074e-10 FALSE TRUE
ENST00000510307 ENSG00000129187 HEK293_OSMI2_2hA HEK293_TMG_2hB DCTD protein_coding protein_coding 30.61716 35.58777 29.90871 2.899414 0.409835 -0.2507387 2.198472 2.218540 2.491775 0.3269120 0.2678271 0.1668530 0.07255417 0.06283333 0.08340000 0.02056667 0.500254775 1.219074e-10 FALSE FALSE
ENST00000510370 ENSG00000129187 HEK293_OSMI2_2hA HEK293_TMG_2hB DCTD protein_coding protein_coding 30.61716 35.58777 29.90871 2.899414 0.409835 -0.2507387 2.062898 1.762514 2.611112 0.2041483 0.2919158 0.5643823 0.06723750 0.04953333 0.08706667 0.03753333 0.022736906 1.219074e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129187 E001 0.6621601 0.0165629108 7.493508e-01 8.363236e-01 4 182838348 182838394 47 - 0.244 0.193 -0.427
ENSG00000129187 E002 1.3995737 0.0094276198 3.200866e-01 4.631970e-01 4 182874656 182874701 46 - 0.244 0.429 1.158
ENSG00000129187 E003 0.8136755 0.0145903455 4.236605e-01 5.667204e-01 4 182877511 182877574 64 - 0.329 0.193 -1.013
ENSG00000129187 E004 1.4695947 0.1242815134 7.045009e-02 1.440869e-01 4 182877575 182877760 186 - 0.561 0.196 -2.208
ENSG00000129187 E005 0.4782907 0.0217681645 1.474162e-01 2.581774e-01 4 182890060 182890090 31 - 0.000 0.265 10.183
ENSG00000129187 E006 3.8715281 0.0166626247 4.402424e-03 1.427125e-02 4 182890091 182890103 13 - 0.329 0.819 2.303
ENSG00000129187 E007 69.9920180 0.0004035508 2.774901e-14 8.545134e-13 4 182890104 182890254 151 - 1.588 1.956 1.244
ENSG00000129187 E008 654.9918906 0.0017801771 3.052802e-11 5.872111e-10 4 182890255 182890980 726 - 2.704 2.861 0.524
ENSG00000129187 E009 150.8528388 0.0002963626 9.005809e-01 9.405726e-01 4 182890981 182890998 18 - 2.164 2.180 0.052
ENSG00000129187 E010 132.2662047 0.0002867031 9.883827e-01 9.967952e-01 4 182890999 182891013 15 - 2.109 2.120 0.038
ENSG00000129187 E011 393.7186627 0.0009019948 2.955531e-01 4.366796e-01 4 182891014 182891371 358 - 2.568 2.599 0.106
ENSG00000129187 E012 113.7351488 0.0002852735 1.013358e-01 1.925051e-01 4 182891372 182891402 31 - 2.009 2.077 0.226
ENSG00000129187 E013 144.5551955 0.0002553081 2.071910e-01 3.351554e-01 4 182891403 182891428 26 - 2.123 2.173 0.166
ENSG00000129187 E014 151.4695772 0.0037922840 1.385076e-01 2.460233e-01 4 182891429 182891477 49 - 2.130 2.196 0.221
ENSG00000129187 E015 196.6455652 0.0002528086 7.039923e-02 1.440132e-01 4 182893031 182893127 97 - 2.251 2.310 0.196
ENSG00000129187 E016 99.5783089 0.0008509611 1.617221e-01 2.773703e-01 4 182894489 182894492 4 - 2.022 1.982 -0.135
ENSG00000129187 E017 174.8233934 0.0001988596 8.666007e-01 9.181271e-01 4 182894493 182894553 61 - 2.233 2.240 0.024
ENSG00000129187 E018 207.1189423 0.0005163482 7.127564e-02 1.454423e-01 4 182894554 182894605 52 - 2.333 2.297 -0.120
ENSG00000129187 E019 0.3289534 0.0302487334 8.167989e-01   4 182911223 182911503 281 - 0.139 0.107 -0.427
ENSG00000129187 E020 175.1140890 0.0034320616 8.167661e-02 1.621813e-01 4 182914923 182914945 23 - 2.271 2.216 -0.186
ENSG00000129187 E021 177.1225451 0.0027435761 4.429844e-02 9.892853e-02 4 182914946 182914982 37 - 2.280 2.220 -0.201
ENSG00000129187 E022 115.2550834 0.0030725247 3.655485e-02 8.463126e-02 4 182914983 182914987 5 - 2.104 2.029 -0.253
ENSG00000129187 E023 111.6232018 0.0034935553 5.972740e-02 1.261587e-01 4 182914988 182914989 2 - 2.087 2.016 -0.237
ENSG00000129187 E024 216.0640934 0.0001771712 2.534189e-05 1.534485e-04 4 182914990 182915058 69 - 2.382 2.293 -0.297
ENSG00000129187 E025 185.1730247 0.0002483677 5.632671e-05 3.132887e-04 4 182915461 182915497 37 - 2.316 2.222 -0.314
ENSG00000129187 E026 187.7451453 0.0013885585 3.430876e-03 1.152608e-02 4 182915498 182915575 78 - 2.314 2.232 -0.274
ENSG00000129187 E027 5.7968055 0.0027561212 1.065413e-01 2.004556e-01 4 182915881 182915888 8 - 0.932 0.739 -0.750
ENSG00000129187 E028 9.6285859 0.0184529778 9.843872e-02 1.881336e-01 4 182916286 182916418 133 - 1.129 0.944 -0.676
ENSG00000129187 E029 40.4014432 0.0005569666 1.720148e-03 6.346068e-03 4 182916419 182916539 121 - 1.700 1.540 -0.544
ENSG00000129187 E030 7.7102607 0.0022136838 9.421008e-02 1.817157e-01 4 182916540 182916627 88 - 1.034 0.856 -0.669
ENSG00000129187 E031 21.5015658 0.0039544487 1.540730e-01 2.672123e-01 4 182916673 182916722 50 - 1.407 1.308 -0.345
ENSG00000129187 E032 10.9974828 0.0026082943 1.349965e-02 3.707657e-02 4 182916723 182916725 3 - 1.196 0.961 -0.855
ENSG00000129187 E033 27.2495640 0.0012670615 2.104029e-01 3.390164e-01 4 182916726 182916857 132 - 1.483 1.410 -0.254
ENSG00000129187 E034 28.9339966 0.0014783675 3.306795e-01 4.742802e-01 4 182916858 182917253 396 - 1.499 1.446 -0.183
ENSG00000129187 E035 53.8968717 0.0029647551 3.138709e-02 7.465880e-02 4 182917288 182917310 23 - 1.791 1.683 -0.366
ENSG00000129187 E036 67.4279821 0.0083661646 6.082130e-02 1.280197e-01 4 182917311 182917477 167 - 1.888 1.775 -0.381
ENSG00000129187 E037 0.0000000       4 182917873 182917936 64 -