ENSG00000129173

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250024 ENSG00000129173 HEK293_OSMI2_2hA HEK293_TMG_2hB E2F8 protein_coding protein_coding 5.195864 3.026278 6.591232 0.1959763 0.1282315 1.120431 1.8658161 0.9071771 1.8527460 0.20465189 0.57361831 1.0221588 0.31164583 0.2941667 0.27900000 -0.01516667 0.954525974 0.006478029 FALSE TRUE
ENST00000527884 ENSG00000129173 HEK293_OSMI2_2hA HEK293_TMG_2hB E2F8 protein_coding protein_coding 5.195864 3.026278 6.591232 0.1959763 0.1282315 1.120431 1.9796565 1.7106983 2.8379799 0.08714896 0.12270824 0.7269448 0.45017083 0.5727667 0.43116667 -0.14160000 0.257554466 0.006478029 FALSE TRUE
ENST00000529188 ENSG00000129173 HEK293_OSMI2_2hA HEK293_TMG_2hB E2F8 protein_coding processed_transcript 5.195864 3.026278 6.591232 0.1959763 0.1282315 1.120431 0.5584296 0.1749457 0.3074168 0.04094850 0.05800918 0.7792768 0.09939583 0.0575000 0.04673333 -0.01076667 0.820248199 0.006478029   FALSE
ENST00000620009 ENSG00000129173 HEK293_OSMI2_2hA HEK293_TMG_2hB E2F8 protein_coding protein_coding 5.195864 3.026278 6.591232 0.1959763 0.1282315 1.120431 0.2872360 0.1228198 0.1909059 0.06196798 0.12069588 0.5970491 0.05381250 0.0406000 0.02970000 -0.01090000 0.880047440 0.006478029 FALSE TRUE
MSTRG.5270.4 ENSG00000129173 HEK293_OSMI2_2hA HEK293_TMG_2hB E2F8 protein_coding   5.195864 3.026278 6.591232 0.1959763 0.1282315 1.120431 0.5047253 0.1106371 1.4021831 0.04389321 0.34360544 3.5491814 0.08498750 0.0350000 0.21343333 0.17843333 0.006478029 0.006478029 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129173 E001 0.4031496 0.0245860841 0.0780408273 0.1563282926 11 19224063 19224065 3 - 0.000 0.281 10.947
ENSG00000129173 E002 49.9693886 0.0347116998 0.0001647378 0.0008124402 11 19224066 19224595 530 - 1.510 1.892 1.296
ENSG00000129173 E003 53.3859672 0.0005129664 0.3583828522 0.5027773917 11 19224596 19224840 245 - 1.699 1.758 0.203
ENSG00000129173 E004 84.0875769 0.0004919014 0.0812745043 0.1615436615 11 19225221 19225519 299 - 1.881 1.963 0.276
ENSG00000129173 E005 32.5064186 0.0009532573 0.4463301234 0.5878346731 11 19225520 19225544 25 - 1.482 1.545 0.216
ENSG00000129173 E006 36.4482251 0.0060115809 0.3585912352 0.5029915129 11 19225545 19225615 71 - 1.527 1.604 0.265
ENSG00000129173 E007 38.5259421 0.0007478723 0.2588628152 0.3961878071 11 19225732 19225864 133 - 1.547 1.627 0.272
ENSG00000129173 E008 1.5886424 0.0099002452 0.7523916335 0.8385965963 11 19225865 19226078 214 - 0.420 0.374 -0.259
ENSG00000129173 E009 79.3267180 0.0004209443 0.7698628210 0.8514179612 11 19229454 19229988 535 - 1.878 1.906 0.093
ENSG00000129173 E010 25.5472351 0.0007435279 0.0956242336 0.1838282666 11 19230241 19230328 88 - 1.356 1.485 0.446
ENSG00000129173 E011 40.6885830 0.0005384278 0.7816131020 0.8596922761 11 19230631 19230834 204 - 1.591 1.622 0.106
ENSG00000129173 E012 37.3485965 0.0007162737 0.9250494564 0.9568071695 11 19232234 19232371 138 - 1.561 1.583 0.073
ENSG00000129173 E013 41.9072485 0.0006149866 0.8997203289 0.9400255674 11 19234360 19234521 162 - 1.609 1.632 0.077
ENSG00000129173 E014 57.9146455 0.0004573259 0.0002061885 0.0009905610 11 19234744 19235058 315 - 1.812 1.650 -0.550
ENSG00000129173 E015 19.4799832 0.0182298645 0.0372680966 0.0859830855 11 19237314 19237346 33 - 1.365 1.165 -0.702
ENSG00000129173 E016 36.0878840 0.0084392134 0.0037300124 0.0123828491 11 19237347 19237470 124 - 1.621 1.423 -0.681
ENSG00000129173 E017 45.8287349 0.0005528556 0.0003303720 0.0015022801 11 19237854 19238132 279 - 1.714 1.534 -0.615
ENSG00000129173 E018 18.7685626 0.0045855891 0.0125094951 0.0347577302 11 19240107 19240230 124 - 1.347 1.138 -0.734
ENSG00000129173 E019 18.0789968 0.0011216461 0.0024787832 0.0087004491 11 19240548 19240945 398 - 1.342 1.092 -0.885
ENSG00000129173 E020 0.8094091 0.0161356371 0.8104149555 0.8796857689 11 19241407 19241496 90 - 0.230 0.281 0.378
ENSG00000129173 E021 3.7623306 0.0045997276 0.0508659353 0.1107173911 11 19241497 19241620 124 - 0.753 0.450 -1.358