ENSG00000129116

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000507735 ENSG00000129116 HEK293_OSMI2_2hA HEK293_TMG_2hB PALLD protein_coding protein_coding 8.457299 7.153244 11.25877 0.4584375 0.2296029 0.653645 1.6312929 1.0278971 3.2692528 0.1980105 0.3800861 1.6597037 0.18907917 0.14130000 0.29020000 0.148900000 0.02069619 0.02069619 FALSE TRUE
ENST00000512127 ENSG00000129116 HEK293_OSMI2_2hA HEK293_TMG_2hB PALLD protein_coding protein_coding 8.457299 7.153244 11.25877 0.4584375 0.2296029 0.653645 0.5552325 0.2993128 1.0017860 0.2993128 0.4142560 1.7097658 0.06249583 0.03790000 0.08806667 0.050166667 0.36191185 0.02069619 FALSE TRUE
MSTRG.25706.14 ENSG00000129116 HEK293_OSMI2_2hA HEK293_TMG_2hB PALLD protein_coding   8.457299 7.153244 11.25877 0.4584375 0.2296029 0.653645 5.6900555 5.4131768 6.3360317 0.1411588 0.4117601 0.2267165 0.68220417 0.76130000 0.56326667 -0.198033333 0.02893185 0.02069619 FALSE TRUE
MSTRG.25706.5 ENSG00000129116 HEK293_OSMI2_2hA HEK293_TMG_2hB PALLD protein_coding   8.457299 7.153244 11.25877 0.4584375 0.2296029 0.653645 0.5014967 0.3983704 0.5524372 0.2490775 0.3006125 0.4618140 0.05692917 0.05723333 0.04986667 -0.007366667 1.00000000 0.02069619 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129116 E001 0.0000000       4 168497052 168497065 14 +      
ENSG00000129116 E002 0.0000000       4 168497066 168497123 58 +      
ENSG00000129116 E003 0.0000000       4 168497124 168497194 71 +      
ENSG00000129116 E004 0.0000000       4 168507360 168507698 339 +      
ENSG00000129116 E005 0.0000000       4 168511423 168511567 145 +      
ENSG00000129116 E006 0.1472490 0.0425822363 7.492603e-01   4 168511568 168512412 845 + 0.094 0.000 -8.673
ENSG00000129116 E007 1.5845028 0.0423387731 5.991306e-01 7.205885e-01 4 168631609 168631614 6 + 0.430 0.365 -0.364
ENSG00000129116 E008 1.4393301 0.1297016170 7.575975e-01 8.423594e-01 4 168631615 168631616 2 + 0.390 0.365 -0.139
ENSG00000129116 E009 3.0894858 0.1020635582 1.430300e-01 2.521506e-01 4 168631617 168631726 110 + 0.687 0.441 -1.136
ENSG00000129116 E010 7.6989268 0.1073819473 2.398234e-01 3.739256e-01 4 168631727 168631900 174 + 0.976 0.836 -0.530
ENSG00000129116 E011 0.0000000       4 168648777 168648888 112 +      
ENSG00000129116 E012 0.0000000       4 168654732 168654812 81 +      
ENSG00000129116 E013 11.8029163 0.0059909362 7.181509e-01 8.133454e-01 4 168668190 168668368 179 + 1.084 1.094 0.039
ENSG00000129116 E014 0.0000000       4 168677900 168678048 149 +      
ENSG00000129116 E015 7.7072536 0.0021826535 5.584531e-01 6.866876e-01 4 168681332 168681398 67 + 0.877 0.990 0.424
ENSG00000129116 E016 10.0717747 0.0385674474 3.386244e-01 4.825067e-01 4 168682998 168683103 106 + 1.067 0.972 -0.347
ENSG00000129116 E017 8.9131258 0.0289557285 1.879384e-01 3.111299e-01 4 168685485 168685559 75 + 1.038 0.903 -0.504
ENSG00000129116 E018 11.4681301 0.0365663219 2.984127e-01 4.398493e-01 4 168690603 168690744 142 + 1.125 1.026 -0.361
ENSG00000129116 E019 5.7198061 0.0028844527 1.896098e-01 3.132663e-01 4 168691269 168691292 24 + 0.863 0.731 -0.521
ENSG00000129116 E020 0.0000000       4 168700019 168700900 882 +      
ENSG00000129116 E021 9.2865334 0.0018920187 9.654362e-01 9.822664e-01 4 168709028 168709147 120 + 0.976 1.027 0.188
ENSG00000129116 E022 15.0913934 0.0016345121 9.384951e-01 9.653909e-01 4 168711581 168711923 343 + 1.170 1.225 0.195
ENSG00000129116 E023 0.1451727 0.0428021937 7.496025e-01   4 168712159 168712274 116 + 0.094 0.000 -10.593
ENSG00000129116 E024 0.0000000       4 168832005 168832016 12 +      
ENSG00000129116 E025 0.5953508 0.0199493137 6.420546e-01 7.549362e-01 4 168832017 168832027 11 + 0.171 0.273 0.853
ENSG00000129116 E026 16.0506826 0.0012703290 8.478925e-05 4.507034e-04 4 168832028 168832171 144 + 1.324 1.008 -1.126
ENSG00000129116 E027 48.1078047 0.0010678155 3.660414e-05 2.129382e-04 4 168877723 168878394 672 + 1.742 1.567 -0.592
ENSG00000129116 E028 65.3628559 0.0051990324 3.975314e-06 2.894022e-05 4 168890922 168891057 136 + 1.882 1.670 -0.716
ENSG00000129116 E029 0.1515154 0.0422101022 7.491916e-01   4 168894169 168894440 272 + 0.094 0.000 -10.599
ENSG00000129116 E030 0.1451727 0.0428021937 7.496025e-01   4 168894441 168894578 138 + 0.094 0.000 -10.593
ENSG00000129116 E031 54.3617712 0.0015453314 7.144252e-02 1.457305e-01 4 168894579 168894640 62 + 1.746 1.704 -0.141
ENSG00000129116 E032 48.0220484 0.0032143824 1.364187e-01 2.430671e-01 4 168894641 168894677 37 + 1.691 1.657 -0.118
ENSG00000129116 E033 0.2955422 0.0280108170 7.297952e-01   4 168896549 168896599 51 + 0.094 0.158 0.854
ENSG00000129116 E034 0.0000000       4 168897977 168898492 516 +      
ENSG00000129116 E035 51.0537483 0.0037776881 3.422490e-02 8.019052e-02 4 168898493 168898558 66 + 1.728 1.658 -0.239
ENSG00000129116 E036 69.5390905 0.0098900535 2.114987e-01 3.402612e-01 4 168898559 168898714 156 + 1.843 1.820 -0.078
ENSG00000129116 E037 76.1752282 0.0090139567 1.712483e-01 2.898124e-01 4 168903757 168903906 150 + 1.888 1.856 -0.106
ENSG00000129116 E038 0.1515154 0.0422101022 7.491916e-01   4 168903907 168904261 355 + 0.094 0.000 -10.599
ENSG00000129116 E039 62.8252077 0.0004257836 7.099233e-02 1.449854e-01 4 168913927 168914021 95 + 1.807 1.776 -0.105
ENSG00000129116 E040 0.1515154 0.0422101022 7.491916e-01   4 168914022 168914075 54 + 0.094 0.000 -10.599
ENSG00000129116 E041 79.0188222 0.0007663259 2.928050e-02 7.054512e-02 4 168915895 168916027 133 + 1.907 1.868 -0.133
ENSG00000129116 E042 53.2763899 0.0004147396 3.745354e-02 8.631574e-02 4 168921534 168921574 41 + 1.744 1.692 -0.175
ENSG00000129116 E043 87.7229270 0.0003637896 1.475564e-01 2.583679e-01 4 168921575 168921741 167 + 1.939 1.934 -0.015
ENSG00000129116 E044 83.7710869 0.0003490654 4.684101e-02 1.035472e-01 4 168924255 168924420 166 + 1.929 1.902 -0.090
ENSG00000129116 E045 94.6068063 0.0003651132 1.342961e-01 2.401231e-01 4 168924945 168925078 134 + 1.972 1.968 -0.014
ENSG00000129116 E046 0.0000000       4 168925233 168925278 46 +      
ENSG00000129116 E047 0.1472490 0.0425822363 7.492603e-01   4 168925279 168925393 115 + 0.094 0.000 -10.595
ENSG00000129116 E048 573.7178450 0.0035933598 1.710995e-15 6.276972e-14 4 168926213 168928457 2245 + 2.643 2.873 0.767