ENSG00000129071

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000429544 ENSG00000129071 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD4 protein_coding protein_coding 16.8549 8.350488 25.64513 0.4195035 0.8491447 1.617588 6.8319330 4.9131000 9.8753995 0.08998118 0.7104285 1.005732 0.43070417 0.59146667 0.38416667 -0.20730000 2.177329e-04 4.685045e-19 FALSE TRUE
ENST00000507208 ENSG00000129071 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD4 protein_coding protein_coding 16.8549 8.350488 25.64513 0.4195035 0.8491447 1.617588 4.7624447 1.7340043 6.9756861 0.15826142 0.1919080 2.001998 0.27172917 0.20823333 0.27233333 0.06410000 1.627335e-01 4.685045e-19 FALSE TRUE
ENST00000511009 ENSG00000129071 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD4 protein_coding retained_intron 16.8549 8.350488 25.64513 0.4195035 0.8491447 1.617588 0.9074652 0.3170686 0.9703013 0.12604056 0.2087558 1.583632 0.05690417 0.03760000 0.03780000 0.00020000 1.000000e+00 4.685045e-19   FALSE
ENST00000515266 ENSG00000129071 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD4 protein_coding retained_intron 16.8549 8.350488 25.64513 0.4195035 0.8491447 1.617588 2.3164989 0.8263546 3.5599166 0.34178796 0.3728122 2.093704 0.12160833 0.09533333 0.13866667 0.04333333 5.966266e-01 4.685045e-19 FALSE FALSE
MSTRG.23694.7 ENSG00000129071 HEK293_OSMI2_2hA HEK293_TMG_2hB MBD4 protein_coding   16.8549 8.350488 25.64513 0.4195035 0.8491447 1.617588 0.6869787 0.0000000 2.5315584 0.00000000 0.1474297 7.989570 0.02661667 0.00000000 0.09856667 0.09856667 4.685045e-19 4.685045e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000129071 E001 0.1515154 0.0433691032 1.000000e+00   3 129430947 129430949 3 - 0.086 0.000 -8.216
ENSG00000129071 E002 0.1515154 0.0433691032 1.000000e+00   3 129430950 129430951 2 - 0.086 0.000 -8.213
ENSG00000129071 E003 12.3541354 0.0336297966 1.694426e-01 2.874653e-01 3 129430952 129431265 314 - 1.043 1.224 0.646
ENSG00000129071 E004 74.6515497 0.0097059997 4.355934e-04 1.911290e-03 3 129431266 129431454 189 - 1.774 1.990 0.727
ENSG00000129071 E005 104.1290879 0.0012427775 2.358162e-08 2.710677e-07 3 129431455 129431578 124 - 1.922 2.128 0.690
ENSG00000129071 E006 46.5487825 0.0083848319 4.113384e-01 5.549097e-01 3 129432176 129432502 327 - 1.677 1.616 -0.207
ENSG00000129071 E007 75.6756941 0.0003977792 4.455576e-05 2.541155e-04 3 129432503 129432532 30 - 1.804 1.967 0.549
ENSG00000129071 E008 81.3045485 0.0032766296 7.971256e-03 2.370543e-02 3 129432533 129432555 23 - 1.853 1.976 0.414
ENSG00000129071 E009 84.1350060 0.0052715798 6.590162e-03 2.016029e-02 3 129432556 129432576 21 - 1.861 1.999 0.463
ENSG00000129071 E010 90.1609765 0.0003780615 5.325897e-03 1.681945e-02 3 129432577 129432606 30 - 1.904 2.006 0.341
ENSG00000129071 E011 175.0552530 0.0006364089 1.818686e-01 3.035690e-01 3 129433098 129433247 150 - 2.215 2.249 0.114
ENSG00000129071 E012 5.5224856 0.0307046147 9.254086e-01 9.570395e-01 3 129433248 129433553 306 - 0.810 0.799 -0.046
ENSG00000129071 E013 96.6171051 0.0002699519 2.198045e-01 3.501653e-01 3 129433850 129433858 9 - 1.988 1.936 -0.173
ENSG00000129071 E014 171.9200529 0.0007073651 5.574665e-01 6.858662e-01 3 129433859 129433984 126 - 2.213 2.224 0.039
ENSG00000129071 E015 7.7426844 0.0188825619 6.678393e-02 1.380390e-01 3 129433985 129434061 77 - 0.998 0.731 -1.031
ENSG00000129071 E016 127.8953106 0.0057691348 7.151160e-01 8.111447e-01 3 129434062 129434133 72 - 2.099 2.072 -0.090
ENSG00000129071 E017 73.8854394 0.0031829532 6.057190e-01 7.260570e-01 3 129434134 129434136 3 - 1.866 1.833 -0.112
ENSG00000129071 E018 24.2751551 0.0007612698 1.145215e-01 2.121440e-01 3 129436443 129436460 18 - 1.424 1.299 -0.433
ENSG00000129071 E019 303.7039722 0.0019392645 5.668893e-04 2.409753e-03 3 129436461 129437046 586 - 2.496 2.394 -0.341
ENSG00000129071 E020 112.9134371 0.0003003705 2.289718e-03 8.118640e-03 3 129437047 129437197 151 - 2.073 1.958 -0.385
ENSG00000129071 E021 83.4832087 0.0084241057 5.145661e-02 1.117425e-01 3 129437198 129437308 111 - 1.945 1.820 -0.419
ENSG00000129071 E022 82.4366308 0.0003286262 5.699169e-04 2.421265e-03 3 129437720 129437807 88 - 1.948 1.797 -0.510
ENSG00000129071 E023 117.8221516 0.0062214614 6.744127e-02 1.390962e-01 3 129437808 129437950 143 - 2.085 1.986 -0.331
ENSG00000129071 E024 95.2166937 0.0103658403 3.841077e-02 8.812146e-02 3 129439730 129440179 450 - 2.004 1.870 -0.452