ENSG00000128989

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000249822 ENSG00000128989 HEK293_OSMI2_2hA HEK293_TMG_2hB ARPP19 protein_coding protein_coding 32.90445 14.30757 57.01055 4.20683 1.656885 1.993695 17.121917 7.3941207 28.975628 1.9730412 2.0192893 1.968937 0.51557917 0.52510000 0.50703333 -0.01806667 0.89139590 0.005463659 FALSE  
ENST00000564163 ENSG00000128989 HEK293_OSMI2_2hA HEK293_TMG_2hB ARPP19 protein_coding protein_coding 32.90445 14.30757 57.01055 4.20683 1.656885 1.993695 2.345629 0.4962044 7.017957 0.1787595 0.9282226 3.795314 0.05384167 0.03493333 0.12410000 0.08916667 0.01098014 0.005463659 FALSE  
ENST00000566423 ENSG00000128989 HEK293_OSMI2_2hA HEK293_TMG_2hB ARPP19 protein_coding protein_coding 32.90445 14.30757 57.01055 4.20683 1.656885 1.993695 2.382621 1.0791769 2.844909 0.1478644 0.5037416 1.390206 0.07839167 0.08196667 0.05046667 -0.03150000 0.35524321 0.005463659 FALSE  
MSTRG.10834.3 ENSG00000128989 HEK293_OSMI2_2hA HEK293_TMG_2hB ARPP19 protein_coding   32.90445 14.30757 57.01055 4.20683 1.656885 1.993695 7.755517 4.6887625 12.811625 2.1581053 0.8027410 1.448226 0.27205833 0.29610000 0.22426667 -0.07183333 0.66200739 0.005463659    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128989 E001 438.1679939 0.0119113545 1.116010e-17 5.444880e-16 15 52547045 52547721 677 - 2.388 2.901 1.709
ENSG00000128989 E002 489.4078937 0.0106538120 1.577852e-02 4.223516e-02 15 52547722 52548268 547 - 2.573 2.765 0.638
ENSG00000128989 E003 730.2238954 0.0001116067 4.070180e-06 2.954343e-05 15 52548269 52549526 1258 - 2.807 2.801 -0.020
ENSG00000128989 E004 808.2169707 0.0023979282 8.842410e-17 3.835970e-15 15 52549527 52551260 1734 - 2.882 2.714 -0.560
ENSG00000128989 E005 175.8152984 0.0002115279 1.539820e-01 2.670863e-01 15 52551261 52551366 106 - 2.161 2.265 0.346
ENSG00000128989 E006 223.9396231 0.0024306960 2.123431e-03 7.606360e-03 15 52551367 52551593 227 - 2.249 2.403 0.514
ENSG00000128989 E007 66.0493262 0.0006166088 1.704384e-01 2.887286e-01 15 52551594 52551648 55 - 1.737 1.864 0.428
ENSG00000128989 E008 74.7249658 0.0003849525 5.186600e-01 6.528896e-01 15 52551649 52551671 23 - 1.799 1.889 0.305
ENSG00000128989 E009 102.7013047 0.0017806014 6.511783e-01 7.621163e-01 15 52551672 52551734 63 - 1.948 1.985 0.124
ENSG00000128989 E010 108.1373388 0.0126027550 6.906188e-01 7.922664e-01 15 52551735 52551768 34 - 1.975 1.979 0.013
ENSG00000128989 E011 118.4277739 0.0051479099 3.741612e-01 5.185804e-01 15 52551769 52551808 40 - 2.016 2.018 0.005
ENSG00000128989 E012 177.7253456 0.0041813774 2.323536e-01 3.652367e-01 15 52551809 52551919 111 - 2.193 2.194 0.001
ENSG00000128989 E013 171.2560573 0.0009338174 7.187379e-05 3.893033e-04 15 52551920 52552008 89 - 2.196 2.118 -0.261
ENSG00000128989 E014 200.5350429 0.0035317688 1.882671e-04 9.135920e-04 15 52552009 52552104 96 - 2.268 2.160 -0.360
ENSG00000128989 E015 0.4482035 0.0276978488 5.129429e-01 6.478237e-01 15 52556997 52557099 103 - 0.179 0.001 -8.276
ENSG00000128989 E016 201.1646273 0.0027337087 8.066763e-04 3.282480e-03 15 52557100 52557222 123 - 2.263 2.184 -0.265
ENSG00000128989 E017 1.2879008 0.3012505888 1.188510e-01 2.183092e-01 15 52557223 52557744 522 - 0.179 0.559 2.362
ENSG00000128989 E018 16.5762730 0.0070393214 1.230150e-03 4.742825e-03 15 52564190 52564246 57 - 1.247 0.928 -1.159
ENSG00000128989 E019 2.2111623 0.0077226386 3.330056e-01 4.766853e-01 15 52568289 52568847 559 - 0.403 0.614 1.024
ENSG00000128989 E020 113.3650396 0.0016364535 1.150515e-05 7.539836e-05 15 52568848 52568900 53 - 2.028 1.886 -0.478
ENSG00000128989 E021 56.4022604 0.0032676702 5.990160e-04 2.529744e-03 15 52568901 52568902 2 - 1.734 1.569 -0.562
ENSG00000128989 E022 80.7578027 0.0100445541 9.443697e-04 3.769341e-03 15 52568903 52569030 128 - 1.892 1.699 -0.651
ENSG00000128989 E023 1.9499643 0.0079753898 4.522854e-01 5.931502e-01 15 52569112 52569115 4 - 0.458 0.351 -0.588
ENSG00000128989 E024 12.4906447 0.0390964820 4.237024e-01 5.667524e-01 15 52569116 52569221 106 - 1.093 1.013 -0.292
ENSG00000128989 E025 0.0000000       15 52569222 52569239 18 -      
ENSG00000128989 E026 0.0000000       15 52569722 52569883 162 -      
ENSG00000128989 E027 8.5743745 0.0027510380 2.346629e-02 5.871515e-02 15 52634215 52634257 43 - 0.986 0.729 -0.995