ENSG00000128951

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331200 ENSG00000128951 HEK293_OSMI2_2hA HEK293_TMG_2hB DUT protein_coding protein_coding 52.7835 58.35521 68.64386 4.388212 1.430367 0.2342321 7.256921 6.07680932 10.093523 0.63416407 0.7262401 0.731100361 0.14039167 0.1037 0.1467667 0.04306667 8.811496e-03 1.847924e-05 FALSE TRUE
ENST00000455976 ENSG00000128951 HEK293_OSMI2_2hA HEK293_TMG_2hB DUT protein_coding protein_coding 52.7835 58.35521 68.64386 4.388212 1.430367 0.2342321 39.448530 49.92904979 49.808826 3.56981618 1.5388941 -0.003477337 0.74417083 0.8561 0.7258667 -0.13023333 1.847924e-05 1.847924e-05 FALSE TRUE
ENST00000559935 ENSG00000128951 HEK293_OSMI2_2hA HEK293_TMG_2hB DUT protein_coding protein_coding 52.7835 58.35521 68.64386 4.388212 1.430367 0.2342321 2.327701 0.07390228 4.296165 0.07390228 1.4664049 5.681549980 0.03865417 0.0014 0.0626000 0.06120000 2.138736e-03 1.847924e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128951 E001 0.1515154 0.0426345359 5.203753e-01   15 48330870 48331010 141 + 0.116 0.000 -8.832
ENSG00000128951 E002 0.6653823 0.0170429169 3.392016e-01 4.831250e-01 15 48331011 48331094 84 + 0.282 0.130 -1.396
ENSG00000128951 E003 2.7854097 0.0359664602 1.053646e-01 1.986509e-01 15 48331095 48331191 97 + 0.695 0.437 -1.190
ENSG00000128951 E004 1.9647235 0.0381364579 6.533534e-01 7.638615e-01 15 48331405 48331428 24 + 0.496 0.438 -0.297
ENSG00000128951 E005 27.3758473 0.0052943317 1.960159e-04 9.468770e-04 15 48331429 48331455 27 + 1.568 1.330 -0.821
ENSG00000128951 E006 49.9754968 0.0006075801 4.011268e-05 2.311271e-04 15 48331456 48331472 17 + 1.790 1.619 -0.580
ENSG00000128951 E007 53.2078704 0.0004905920 4.848712e-04 2.102385e-03 15 48331473 48331479 7 + 1.801 1.667 -0.452
ENSG00000128951 E008 92.7259527 0.0006182535 3.314634e-05 1.950390e-04 15 48331480 48331726 247 + 2.032 1.909 -0.413
ENSG00000128951 E009 41.2577056 0.0005482216 5.275566e-04 2.262712e-03 15 48331727 48331795 69 + 1.700 1.544 -0.529
ENSG00000128951 E010 149.2519660 0.0092947466 8.147678e-01 8.826267e-01 15 48332103 48332209 107 + 2.166 2.183 0.056
ENSG00000128951 E011 381.9809347 0.0066803643 6.739515e-01 7.795136e-01 15 48332210 48332267 58 + 2.558 2.604 0.154
ENSG00000128951 E012 761.1332568 0.0032683917 2.650942e-01 4.031185e-01 15 48332268 48332405 138 + 2.884 2.880 -0.013
ENSG00000128951 E013 424.0508535 0.0044456856 1.145947e-01 2.122492e-01 15 48332406 48332406 1 + 2.642 2.615 -0.092
ENSG00000128951 E014 1.4317517 0.0501764835 1.805163e-02 4.724366e-02 15 48332407 48332737 331 + 0.116 0.574 3.171
ENSG00000128951 E015 604.5155812 0.0023903058 3.413973e-02 8.003180e-02 15 48334417 48334444 28 + 2.795 2.769 -0.088
ENSG00000128951 E016 854.4893650 0.0001105298 5.926994e-05 3.278206e-04 15 48334445 48334508 64 + 2.943 2.928 -0.048
ENSG00000128951 E017 877.4088379 0.0002048655 1.408846e-03 5.336220e-03 15 48336046 48336090 45 + 2.951 2.944 -0.021
ENSG00000128951 E018 8.5344482 0.0635065306 4.167484e-02 9.414258e-02 15 48340145 48340214 70 + 1.109 0.796 -1.174
ENSG00000128951 E019 2.4378200 0.0060392210 5.453864e-02 1.171848e-01 15 48340215 48340236 22 + 0.668 0.378 -1.399
ENSG00000128951 E020 9.6472524 0.0388360242 2.488151e-02 6.162864e-02 15 48341136 48341288 153 + 1.140 0.864 -1.020
ENSG00000128951 E021 1128.4160949 0.0009742754 4.135152e-01 5.569877e-01 15 48341289 48341363 75 + 3.044 3.064 0.066
ENSG00000128951 E022 2.5538334 0.0061565247 1.617240e-01 2.773710e-01 15 48341364 48341458 95 + 0.639 0.437 -0.950
ENSG00000128951 E023 2.7010824 0.0074158637 1.116102e-01 2.079158e-01 15 48341459 48341462 4 + 0.668 0.437 -1.075
ENSG00000128951 E024 6.8102843 0.0362558482 2.898222e-01 4.305605e-01 15 48341463 48341514 52 + 0.951 0.818 -0.509
ENSG00000128951 E025 1050.6937419 0.0015777367 1.252011e-01 2.274279e-01 15 48341515 48341585 71 + 2.990 3.052 0.204
ENSG00000128951 E026 8.4842085 0.0019812046 6.158356e-01 7.340053e-01 15 48341586 48342021 436 + 0.993 0.970 -0.086
ENSG00000128951 E027 1582.4559019 0.0042612697 2.517516e-06 1.916405e-05 15 48342022 48343373 1352 + 3.110 3.271 0.536