ENSG00000128915

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261520 ENSG00000128915 HEK293_OSMI2_2hA HEK293_TMG_2hB ICE2 protein_coding protein_coding 14.19255 3.590881 22.75223 0.09207981 1.147031 2.66022 0.4421956 0.2757259 0.59169835 0.08441231 0.32637040 1.074408 0.04245417 0.07793333 0.02696667 -0.05096667 4.981486e-01 4.73961e-06 FALSE TRUE
ENST00000558121 ENSG00000128915 HEK293_OSMI2_2hA HEK293_TMG_2hB ICE2 protein_coding retained_intron 14.19255 3.590881 22.75223 0.09207981 1.147031 2.66022 2.1578016 1.1261987 2.95570779 0.09458470 0.16673717 1.384161 0.20176667 0.31526667 0.12983333 -0.18543333 4.739610e-06 4.73961e-06   FALSE
ENST00000560072 ENSG00000128915 HEK293_OSMI2_2hA HEK293_TMG_2hB ICE2 protein_coding protein_coding 14.19255 3.590881 22.75223 0.09207981 1.147031 2.66022 0.3804579 0.2979388 0.80044069 0.22426352 0.45378213 1.396063 0.04188750 0.08623333 0.03400000 -0.05223333 8.970364e-01 4.73961e-06 FALSE FALSE
ENST00000560895 ENSG00000128915 HEK293_OSMI2_2hA HEK293_TMG_2hB ICE2 protein_coding nonsense_mediated_decay 14.19255 3.590881 22.75223 0.09207981 1.147031 2.66022 0.5231943 0.3213006 0.09848659 0.32130061 0.09848659 -1.610624 0.04988333 0.08763333 0.00400000 -0.08363333 7.790828e-01 4.73961e-06   FALSE
MSTRG.10951.4 ENSG00000128915 HEK293_OSMI2_2hA HEK293_TMG_2hB ICE2 protein_coding   14.19255 3.590881 22.75223 0.09207981 1.147031 2.66022 5.8237209 0.9344223 8.74260662 0.22032522 0.77184742 3.212209 0.35224167 0.25736667 0.38430000 0.12693333 3.104869e-01 4.73961e-06 FALSE TRUE
MSTRG.10951.5 ENSG00000128915 HEK293_OSMI2_2hA HEK293_TMG_2hB ICE2 protein_coding   14.19255 3.590881 22.75223 0.09207981 1.147031 2.66022 2.8122637 0.1967708 6.02727001 0.15091929 0.46391983 4.867792 0.15861667 0.05326667 0.26556667 0.21230000 6.373167e-02 4.73961e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128915 E001 0.0000000       15 60419609 60419612 4 -      
ENSG00000128915 E002 16.7290843 0.0415952687 1.115136e-02 3.152934e-02 15 60419613 60421475 1863 - 1.035 1.405 1.310
ENSG00000128915 E003 148.5714277 0.0121443968 2.233533e-12 5.179145e-11 15 60421476 60423382 1907 - 1.930 2.371 1.473
ENSG00000128915 E004 26.0774892 0.0081470037 6.694907e-07 5.772484e-06 15 60423383 60423397 15 - 1.190 1.644 1.571
ENSG00000128915 E005 116.4921980 0.0025266909 2.895014e-04 1.337165e-03 15 60423398 60423651 254 - 1.890 2.087 0.664
ENSG00000128915 E006 84.4840550 0.0003468077 4.339717e-03 1.409474e-02 15 60423652 60423762 111 - 1.757 1.925 0.567
ENSG00000128915 E007 116.9757283 0.0002588922 2.539456e-02 6.268957e-02 15 60428429 60428687 259 - 1.906 2.029 0.413
ENSG00000128915 E008 51.1449865 0.0004381697 6.488421e-01 7.602683e-01 15 60431934 60431984 51 - 1.577 1.573 -0.011
ENSG00000128915 E009 57.6297390 0.0004206474 8.475905e-01 9.053483e-01 15 60436143 60436227 85 - 1.622 1.637 0.053
ENSG00000128915 E010 4.0811831 0.0186646159 3.290909e-01 4.725920e-01 15 60437820 60440630 2811 - 0.615 0.431 -0.882
ENSG00000128915 E011 1.7906241 0.0475655018 1.374951e-01 2.446031e-01 15 60440631 60440710 80 - 0.398 0.000 -11.180
ENSG00000128915 E012 2.8046429 0.0063325206 3.620509e-02 8.397544e-02 15 60440711 60442415 1705 - 0.528 0.000 -11.724
ENSG00000128915 E013 70.5171619 0.0003624330 3.790358e-03 1.255480e-02 15 60442416 60442545 130 - 1.730 1.574 -0.532
ENSG00000128915 E014 0.5181333 0.0202896723 3.516077e-01 4.958502e-01 15 60442546 60443071 526 - 0.097 0.267 1.764
ENSG00000128915 E015 4.4662469 0.0036261447 1.318577e-01 2.366992e-01 15 60447491 60447969 479 - 0.574 0.841 1.110
ENSG00000128915 E016 85.6124181 0.0004172080 4.692063e-04 2.042268e-03 15 60447970 60448145 176 - 1.815 1.637 -0.602
ENSG00000128915 E017 272.7236726 0.0022129996 1.823250e-06 1.430977e-05 15 60448848 60449841 994 - 2.311 2.161 -0.503
ENSG00000128915 E018 29.9474130 0.0007051420 8.440730e-02 1.664555e-01 15 60451095 60453602 2508 - 1.319 1.487 0.579
ENSG00000128915 E019 56.3954962 0.0004327203 1.347739e-03 5.135465e-03 15 60453603 60453711 109 - 1.642 1.436 -0.706
ENSG00000128915 E020 42.2182819 0.0005218329 1.402508e-03 5.315082e-03 15 60453712 60453784 73 - 1.522 1.274 -0.856
ENSG00000128915 E021 0.4439371 0.0215642094 1.000000e+00 1.000000e+00 15 60454688 60455002 315 - 0.138 0.000 -9.256
ENSG00000128915 E022 54.5028529 0.0005032770 1.179813e-04 6.045767e-04 15 60455003 60455162 160 - 1.632 1.363 -0.925
ENSG00000128915 E023 32.8952152 0.0013065963 1.801397e-03 6.603508e-03 15 60455326 60455355 30 - 1.421 1.137 -0.995
ENSG00000128915 E024 50.3441598 0.0018721749 4.538380e-03 1.464931e-02 15 60455356 60455442 87 - 1.591 1.394 -0.676
ENSG00000128915 E025 29.3865439 0.0007606564 6.961054e-02 1.427096e-01 15 60456657 60456665 9 - 1.359 1.211 -0.519
ENSG00000128915 E026 56.4743121 0.0006424697 3.099265e-03 1.055772e-02 15 60456666 60456760 95 - 1.637 1.449 -0.642
ENSG00000128915 E027 32.4222976 0.0006623412 1.991251e-02 5.130450e-02 15 60456761 60456764 4 - 1.404 1.211 -0.675
ENSG00000128915 E028 34.9975647 0.0067418258 6.131796e-02 1.288504e-01 15 60456765 60456794 30 - 1.431 1.276 -0.540
ENSG00000128915 E029 51.1069529 0.0097633854 2.809608e-02 6.819975e-02 15 60466594 60466672 79 - 1.594 1.424 -0.583
ENSG00000128915 E030 28.8324837 0.0093169409 8.205812e-02 1.627716e-01 15 60466673 60466686 14 - 1.352 1.190 -0.572
ENSG00000128915 E031 30.0930721 0.0008299012 1.370294e-03 5.209361e-03 15 60466687 60466713 27 - 1.387 1.080 -1.084
ENSG00000128915 E032 51.3165460 0.0028802552 2.670691e-02 6.538146e-02 15 60468061 60468162 102 - 1.595 1.449 -0.500
ENSG00000128915 E033 19.8741414 0.0009654394 1.918878e-01 3.161345e-01 15 60468163 60468170 8 - 1.157 1.312 0.544
ENSG00000128915 E034 21.3907776 0.0008690390 1.592223e-01 2.740800e-01 15 60468171 60468186 16 - 1.187 1.346 0.560
ENSG00000128915 E035 45.5075030 0.0005314331 1.805552e-02 4.725187e-02 15 60468187 60468322 136 - 1.495 1.678 0.625
ENSG00000128915 E036 67.9608291 0.0041452690 7.843411e-01 8.616799e-01 15 60476063 60476167 105 - 1.690 1.735 0.151
ENSG00000128915 E037 71.6389676 0.0020867799 3.893498e-01 5.334536e-01 15 60477937 60478069 133 - 1.708 1.786 0.266
ENSG00000128915 E038 8.4729306 0.0036136608 5.212227e-01 6.551013e-01 15 60478568 60478637 70 - 0.860 0.784 -0.296
ENSG00000128915 E039 5.0146473 0.0035060753 8.019024e-01 8.737799e-01 15 60478638 60478650 13 - 0.665 0.643 -0.095
ENSG00000128915 E040 3.2483500 0.0194429425 9.310250e-01 9.605687e-01 15 60478651 60478660 10 - 0.512 0.550 0.180
ENSG00000128915 E041 4.9802050 0.0033255014 4.283118e-01 5.711115e-01 15 60478661 60479002 342 - 0.677 0.549 -0.559
ENSG00000128915 E042 40.0233481 0.0033428462 2.895664e-01 4.302615e-01 15 60479003 60479071 69 - 1.455 1.563 0.373
ENSG00000128915 E043 18.7887952 0.0010420095 6.458790e-01 7.579417e-01 15 60479072 60479160 89 - 1.161 1.137 -0.085