ENSG00000128908

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000558270 ENSG00000128908 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80 protein_coding retained_intron 7.920027 7.130396 8.128468 0.1777066 0.1755997 0.188753 0.7506890 1.003649 0.04648072 0.3836647 0.04648072 -4.16565637 0.09693750 0.1391 0.005966667 -0.13313333 0.01521247 0.01521247 FALSE TRUE
ENST00000560799 ENSG00000128908 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80 protein_coding retained_intron 7.920027 7.130396 8.128468 0.1777066 0.1755997 0.188753 0.3438093 0.000000 0.78910579 0.0000000 0.39879610 6.32031460 0.03745000 0.0000 0.095066667 0.09506667 0.19686513 0.01521247 FALSE FALSE
ENST00000648947 ENSG00000128908 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80 protein_coding protein_coding 7.920027 7.130396 8.128468 0.1777066 0.1755997 0.188753 6.0766148 5.991526 6.12351169 0.2735556 0.21826112 0.03138391 0.77222917 0.8415 0.753200000 -0.08830000 0.42143443 0.01521247 FALSE TRUE
MSTRG.10586.5 ENSG00000128908 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80 protein_coding   7.920027 7.130396 8.128468 0.1777066 0.1755997 0.188753 0.3953326 0.000000 0.70217190 0.0000000 0.37445036 6.15415361 0.04914583 0.0000 0.087900000 0.08790000 0.20698812 0.01521247 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128908 E001 0.1515154 0.0432411946 4.723491e-01   15 40976861 40976892 32 - 0.124 0.000 -11.795
ENSG00000128908 E002 0.9244034 0.0143534721 1.854965e-01 3.081275e-01 15 40978880 40978892 13 - 0.124 0.359 1.964
ENSG00000128908 E003 11.8311558 0.0079253304 1.906952e-02 4.948853e-02 15 40978893 40978927 35 - 0.950 1.206 0.929
ENSG00000128908 E004 84.3217656 0.0038517362 1.282436e-07 1.275950e-06 15 40978928 40979257 330 - 1.764 2.033 0.907
ENSG00000128908 E005 110.4777159 0.0074558352 2.172715e-05 1.335586e-04 15 40979258 40979491 234 - 1.900 2.140 0.804
ENSG00000128908 E006 163.9905843 0.0067446667 2.890055e-06 2.170256e-05 15 40979492 40979910 419 - 2.073 2.307 0.783
ENSG00000128908 E007 121.3912298 0.0011320682 4.699070e-08 5.097484e-07 15 40979911 40980226 316 - 1.964 2.167 0.681
ENSG00000128908 E008 61.9250316 0.0032404834 2.618736e-02 6.432984e-02 15 40980227 40980301 75 - 1.722 1.846 0.417
ENSG00000128908 E009 68.5009992 0.0003988460 1.122841e-04 5.783233e-04 15 40980302 40980440 139 - 1.736 1.912 0.594
ENSG00000128908 E010 77.3459946 0.0003879059 1.162390e-02 3.263648e-02 15 40982862 40983077 216 - 1.832 1.943 0.373
ENSG00000128908 E011 1.7360026 0.0143444668 5.793505e-01 7.042698e-01 15 40983078 40983219 142 - 0.365 0.467 0.550
ENSG00000128908 E012 42.7469270 0.0005189919 4.364591e-02 9.773281e-02 15 40983762 40983797 36 - 1.571 1.689 0.400
ENSG00000128908 E013 74.3564983 0.0013118980 1.839908e-02 4.800840e-02 15 40983798 40983921 124 - 1.815 1.928 0.379
ENSG00000128908 E014 0.1515154 0.0432411946 4.723491e-01   15 40983922 40983986 65 - 0.124 0.000 -11.800
ENSG00000128908 E015 75.5002563 0.0025559088 9.791097e-03 2.824955e-02 15 40984197 40984343 147 - 1.808 1.939 0.439
ENSG00000128908 E016 31.1670297 0.0009096898 2.464439e-01 3.817846e-01 15 40984344 40984349 6 - 1.463 1.544 0.280
ENSG00000128908 E017 26.7565382 0.0076098729 4.477606e-01 5.891255e-01 15 40984350 40984352 3 - 1.405 1.475 0.240
ENSG00000128908 E018 33.0211536 0.0008175825 6.310934e-01 7.461929e-01 15 40985338 40985348 11 - 1.514 1.552 0.131
ENSG00000128908 E019 58.4956628 0.0003929763 6.550171e-01 7.650124e-01 15 40985349 40985426 78 - 1.756 1.786 0.100
ENSG00000128908 E020 73.0829133 0.0003880309 6.618197e-01 7.702121e-01 15 40987091 40987193 103 - 1.870 1.861 -0.031
ENSG00000128908 E021 87.3323527 0.0003385361 7.125750e-01 8.092607e-01 15 40987816 40987974 159 - 1.946 1.942 -0.016
ENSG00000128908 E022 49.1384707 0.0069305819 3.170945e-01 4.599387e-01 15 40997529 40997576 48 - 1.728 1.674 -0.182
ENSG00000128908 E023 35.0086649 0.0127390096 7.837182e-01 8.612277e-01 15 40997577 40997601 25 - 1.560 1.547 -0.044
ENSG00000128908 E024 0.0000000       15 40997602 40997710 109 -      
ENSG00000128908 E025 0.4741261 0.0210466427 5.424999e-01 6.732505e-01 15 41005278 41005592 315 - 0.220 0.121 -1.037
ENSG00000128908 E026 60.7296014 0.0061310192 9.924556e-01 9.993661e-01 15 41005593 41005687 95 - 1.783 1.789 0.021
ENSG00000128908 E027 64.0790474 0.0004221939 6.589603e-01 7.679175e-01 15 41016088 41016215 128 - 1.795 1.823 0.096
ENSG00000128908 E028 86.8655463 0.0062325207 8.632178e-01 9.157980e-01 15 41020900 41021125 226 - 1.940 1.937 -0.011
ENSG00000128908 E029 0.2924217 0.0271239070 1.900519e-01   15 41023226 41023346 121 - 0.220 0.000 -12.799
ENSG00000128908 E030 56.5066175 0.0166999579 6.216928e-01 7.386459e-01 15 41027596 41027736 141 - 1.771 1.739 -0.110
ENSG00000128908 E031 61.0942832 0.0018453579 9.869781e-01 9.959150e-01 15 41044904 41045075 172 - 1.788 1.797 0.031
ENSG00000128908 E032 44.5036001 0.0009164677 6.088191e-01 7.284377e-01 15 41047408 41047501 94 - 1.635 1.672 0.123
ENSG00000128908 E033 41.8481384 0.0005441225 1.386007e-01 2.461609e-01 15 41048212 41048276 65 - 1.670 1.600 -0.238
ENSG00000128908 E034 61.1945333 0.0004549926 3.965013e-03 1.304573e-02 15 41049287 41049420 134 - 1.855 1.735 -0.404
ENSG00000128908 E035 61.6039871 0.0003998667 2.934287e-02 7.066842e-02 15 41049935 41050102 168 - 1.842 1.755 -0.295
ENSG00000128908 E036 43.5552807 0.0044165328 1.416399e-02 3.859629e-02 15 41053929 41054014 86 - 1.722 1.582 -0.477
ENSG00000128908 E037 47.9335073 0.0099527902 1.483268e-03 5.582721e-03 15 41055247 41055364 118 - 1.795 1.581 -0.724
ENSG00000128908 E038 37.6080357 0.0051638453 2.881781e-03 9.916172e-03 15 41056622 41056706 85 - 1.680 1.493 -0.636
ENSG00000128908 E039 46.4768423 0.0005263462 8.156295e-05 4.353862e-04 15 41058639 41058781 143 - 1.769 1.575 -0.656
ENSG00000128908 E040 33.2491265 0.0006487309 4.000287e-02 9.104307e-02 15 41059867 41059926 60 - 1.590 1.476 -0.391
ENSG00000128908 E041 0.1451727 0.0431883399 4.730034e-01   15 41069512 41069569 58 - 0.124 0.000 -11.799
ENSG00000128908 E042 43.0508801 0.0106540591 2.169826e-01 3.467721e-01 15 41069570 41069665 96 - 1.685 1.599 -0.293
ENSG00000128908 E043 40.0000982 0.0069732735 3.775073e-02 8.687124e-02 15 41070467 41070547 81 - 1.676 1.542 -0.456
ENSG00000128908 E044 55.8543783 0.0054820904 1.959578e-02 5.061781e-02 15 41071849 41072058 210 - 1.819 1.692 -0.430
ENSG00000128908 E045 33.1317088 0.0094290737 2.676226e-03 9.301784e-03 15 41073428 41073495 68 - 1.642 1.425 -0.743
ENSG00000128908 E046 52.0620565 0.0048754951 5.135153e-05 2.885393e-04 15 41074370 41074565 196 - 1.834 1.605 -0.777
ENSG00000128908 E047 40.5181101 0.0007613986 6.671896e-09 8.499568e-08 15 41079701 41079904 204 - 1.761 1.447 -1.072
ENSG00000128908 E048 17.9382606 0.0143615469 8.355210e-04 3.385962e-03 15 41081020 41081073 54 - 1.427 1.108 -1.121
ENSG00000128908 E049 44.1730528 0.0012151542 1.273362e-05 8.257216e-05 15 41085369 41085583 215 - 1.764 1.537 -0.772
ENSG00000128908 E050 36.4607920 0.0010094546 4.201253e-03 1.370684e-02 15 41087562 41087682 121 - 1.649 1.490 -0.542
ENSG00000128908 E051 34.7785248 0.0007585687 4.062023e-03 1.331588e-02 15 41092027 41092182 156 - 1.635 1.476 -0.546
ENSG00000128908 E052 18.6760082 0.0069864436 1.278541e-01 2.311881e-01 15 41095601 41095668 68 - 1.363 1.245 -0.412
ENSG00000128908 E053 30.3553193 0.0006611747 1.965548e-02 5.075198e-02 15 41095759 41095928 170 - 1.567 1.432 -0.466
ENSG00000128908 E054 19.6883177 0.0009297410 1.292045e-04 6.553347e-04 15 41096168 41096353 186 - 1.448 1.161 -1.003
ENSG00000128908 E055 0.2966881 0.0270823641 1.899597e-01   15 41115844 41115972 129 - 0.220 0.000 -12.800
ENSG00000128908 E056 6.1857793 0.1017401292 2.073241e-02 5.302246e-02 15 41115973 41116280 308 - 1.038 0.596 -1.754