ENSG00000128891

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358005 ENSG00000128891 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC32 protein_coding protein_coding 9.897961 11.23571 8.988757 1.708269 0.3833788 -0.3215772 3.7263516 5.6578264 2.7848048 1.49938868 0.55942819 -1.0200480 0.37710417 0.48416667 0.30946667 -0.1747000000 0.305881442 0.002261013 FALSE  
ENST00000416810 ENSG00000128891 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC32 protein_coding protein_coding 9.897961 11.23571 8.988757 1.708269 0.3833788 -0.3215772 2.5165639 2.7601286 2.0335006 0.64106622 0.32691397 -0.4389103 0.24419167 0.25923333 0.22836667 -0.0308666667 0.947625811 0.002261013 FALSE  
ENST00000559291 ENSG00000128891 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC32 protein_coding nonsense_mediated_decay 9.897961 11.23571 8.988757 1.708269 0.3833788 -0.3215772 0.4597740 0.4086665 0.3320816 0.02884660 0.03510361 -0.2914609 0.05029167 0.03756667 0.03720000 -0.0003666667 1.000000000 0.002261013 TRUE  
ENST00000560305 ENSG00000128891 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC32 protein_coding protein_coding 9.897961 11.23571 8.988757 1.708269 0.3833788 -0.3215772 0.3473934 0.1780125 0.8252971 0.09389705 0.07622984 2.1514611 0.03670000 0.01930000 0.09146667 0.0721666667 0.128551544 0.002261013 FALSE  
ENST00000561011 ENSG00000128891 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC32 protein_coding protein_coding 9.897961 11.23571 8.988757 1.708269 0.3833788 -0.3215772 1.5303253 1.3202440 1.8725345 0.14525390 0.11980111 0.5009854 0.15742083 0.11940000 0.20796667 0.0885666667 0.002261013 0.002261013 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128891 E001 3.1175854 0.0128338542 1.239900e-03 4.776042e-03 15 40528683 40528790 108 - 0.860 0.356 -2.296
ENSG00000128891 E002 0.0000000       15 40531331 40531340 10 -      
ENSG00000128891 E003 35.1279827 0.0006051395 3.284026e-05 1.935144e-04 15 40531341 40532107 767 - 1.682 1.446 -0.806
ENSG00000128891 E004 17.2771711 0.0011266339 2.151933e-04 1.029209e-03 15 40532108 40532302 195 - 1.415 1.120 -1.035
ENSG00000128891 E005 14.5679137 0.0509350769 7.160008e-01 8.117693e-01 15 40534343 40534899 557 - 1.131 1.198 0.241
ENSG00000128891 E006 11.3387635 0.1193987349 7.935354e-01 8.679879e-01 15 40534900 40535010 111 - 1.104 1.059 -0.166
ENSG00000128891 E007 13.5378509 0.0034184985 2.704512e-01 4.091137e-01 15 40535011 40535486 476 - 1.073 1.182 0.391
ENSG00000128891 E008 4.7490335 0.0194056649 5.393778e-01 6.706495e-01 15 40535487 40535598 112 - 0.677 0.766 0.366
ENSG00000128891 E009 27.9830477 0.0287748855 4.244331e-01 5.674094e-01 15 40535599 40539228 3630 - 1.503 1.398 -0.361
ENSG00000128891 E010 1.2020764 0.5068150817 9.634741e-01 9.809708e-01 15 40539229 40539234 6 - 0.351 0.312 -0.242
ENSG00000128891 E011 1.0203720 0.3854129237 8.405911e-01 9.005070e-01 15 40539235 40539238 4 - 0.351 0.251 -0.666
ENSG00000128891 E012 5.2135721 0.0492957736 3.031392e-01 4.450354e-01 15 40539239 40539355 117 - 0.884 0.705 -0.710
ENSG00000128891 E013 95.0563102 0.0004116134 8.287670e-06 5.610258e-05 15 40553099 40553436 338 - 1.851 2.021 0.571
ENSG00000128891 E014 89.4531647 0.0070051307 1.594866e-03 5.943944e-03 15 40553437 40553594 158 - 1.822 1.991 0.569
ENSG00000128891 E015 88.8264179 0.0004719933 7.040145e-03 2.132917e-02 15 40553595 40553941 347 - 1.871 1.977 0.355
ENSG00000128891 E016 11.3716437 0.0134017803 3.529563e-01 4.972191e-01 15 40553942 40553979 38 - 1.007 1.123 0.422
ENSG00000128891 E017 20.0049874 0.0117284294 7.942014e-01 8.684858e-01 15 40553980 40554017 38 - 1.322 1.311 -0.039
ENSG00000128891 E018 34.7972185 0.0093334706 9.507441e-01 9.731666e-01 15 40554018 40554127 110 - 1.541 1.541 0.000
ENSG00000128891 E019 7.0027690 0.0024848187 8.948719e-01 9.368143e-01 15 40556621 40557215 595 - 0.908 0.895 -0.048
ENSG00000128891 E020 82.8275540 0.0045916156 6.558307e-02 1.360160e-01 15 40557216 40557372 157 - 1.965 1.873 -0.308
ENSG00000128891 E021 0.0000000       15 40561981 40561998 18 -      
ENSG00000128891 E022 0.0000000       15 40561999 40562007 9 -      
ENSG00000128891 E023 0.0000000       15 40562008 40562206 199 -      
ENSG00000128891 E024 122.4613986 0.0015793267 7.901522e-02 1.579379e-01 15 40562772 40563022 251 - 2.114 2.051 -0.212
ENSG00000128891 E025 44.5992208 0.0004945779 5.663439e-01 6.933302e-01 15 40563023 40563027 5 - 1.663 1.635 -0.094
ENSG00000128891 E026 0.1482932 0.0411597534 7.299776e-01   15 40564766 40564790 25 - 0.001 0.098 7.445
ENSG00000128891 E027 51.4882915 0.0008265045 5.925174e-01 7.150574e-01 15 40564791 40564872 82 - 1.725 1.701 -0.082
ENSG00000128891 E028 47.3368806 0.0005412930 9.846467e-01 9.944718e-01 15 40564873 40564975 103 - 1.671 1.672 0.004
ENSG00000128891 E029 45.9016161 0.0110610790 5.091804e-01 6.445198e-01 15 40564976 40565143 168 - 1.689 1.629 -0.202