ENSG00000128881

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267890 ENSG00000128881 HEK293_OSMI2_2hA HEK293_TMG_2hB TTBK2 protein_coding protein_coding 2.605015 1.528685 3.431167 0.2764673 0.1783428 1.1612 1.7544021 0.7502858 2.3776667 0.0584123 0.09211551 1.6509878 0.67142500 0.5103667 0.69610000 0.1857333 1.331992e-01 3.641901e-06 FALSE TRUE
ENST00000567485 ENSG00000128881 HEK293_OSMI2_2hA HEK293_TMG_2hB TTBK2 protein_coding processed_transcript 2.605015 1.528685 3.431167 0.2764673 0.1783428 1.1612 0.3959623 0.5861199 0.2024273 0.1984356 0.20242729 -1.4886335 0.17679583 0.3700667 0.05366667 -0.3164000 6.704316e-02 3.641901e-06 FALSE TRUE
ENST00000567840 ENSG00000128881 HEK293_OSMI2_2hA HEK293_TMG_2hB TTBK2 protein_coding protein_coding 2.605015 1.528685 3.431167 0.2764673 0.1783428 1.1612 0.1188016 0.1537060 0.1175348 0.0600252 0.07476535 -0.3602161 0.05072083 0.1009000 0.03560000 -0.0653000 5.140874e-01 3.641901e-06 FALSE TRUE
MSTRG.10631.2 ENSG00000128881 HEK293_OSMI2_2hA HEK293_TMG_2hB TTBK2 protein_coding   2.605015 1.528685 3.431167 0.2764673 0.1783428 1.1612 0.2511915 0.0000000 0.5763193 0.0000000 0.07688155 5.8736148 0.07262083 0.0000000 0.16846667 0.1684667 3.641901e-06 3.641901e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128881 E001 277.7763279 0.0023995712 1.174134e-13 3.304162e-12 15 42738730 42744895 6166 - 2.340 2.523 0.611
ENSG00000128881 E002 54.4692136 0.0004759170 9.644549e-06 6.436053e-05 15 42744896 42746257 1362 - 1.746 1.527 -0.743
ENSG00000128881 E003 59.4589799 0.0005717538 2.642731e-14 8.168664e-13 15 42751974 42753247 1274 - 1.812 1.386 -1.454
ENSG00000128881 E004 24.5564036 0.0106627610 3.896419e-05 2.252082e-04 15 42775135 42775723 589 - 1.439 1.038 -1.419
ENSG00000128881 E005 0.1515154 0.0436454007 1.000000e+00   15 42776918 42776949 32 - 0.072 0.000 -7.747
ENSG00000128881 E006 1.9186520 0.0075569822 1.628414e-02 4.335213e-02 15 42776950 42777030 81 - 0.281 0.706 2.167
ENSG00000128881 E007 19.0722586 0.0010210533 2.151824e-01 3.446451e-01 15 42777031 42777242 212 - 1.221 1.353 0.466
ENSG00000128881 E008 19.2589160 0.0009767344 6.166162e-01 7.346323e-01 15 42783419 42783635 217 - 1.266 1.253 -0.044
ENSG00000128881 E009 17.0159143 0.0012248637 1.874703e-01 3.105442e-01 15 42794644 42794801 158 - 1.235 1.141 -0.333
ENSG00000128881 E010 14.0720402 0.0403912185 2.651974e-01 4.032364e-01 15 42810614 42810739 126 - 1.164 1.038 -0.458
ENSG00000128881 E011 14.5588281 0.0234698295 6.529510e-02 1.355300e-01 15 42811688 42811780 93 - 1.196 0.988 -0.752
ENSG00000128881 E012 14.0868921 0.0099275851 2.966745e-02 7.130910e-02 15 42817032 42817097 66 - 1.186 0.962 -0.814
ENSG00000128881 E013 12.6635172 0.0013803503 3.194717e-01 4.625546e-01 15 42827928 42827976 49 - 1.113 1.038 -0.274
ENSG00000128881 E014 12.7785380 0.0014952925 7.763100e-01 8.559665e-01 15 42827977 42828032 56 - 1.101 1.102 0.004
ENSG00000128881 E015 8.5723443 0.0021011101 7.810684e-01 8.593376e-01 15 42829938 42829940 3 - 0.927 0.989 0.232
ENSG00000128881 E016 9.1699750 0.0019912381 5.321749e-01 6.645504e-01 15 42829941 42829969 29 - 0.979 0.933 -0.172
ENSG00000128881 E017 12.1423877 0.0015217733 6.297233e-01 7.450367e-01 15 42829970 42830078 109 - 1.082 1.061 -0.078
ENSG00000128881 E018 7.8819302 0.0021485581 9.534443e-01 9.748656e-01 15 42840360 42840433 74 - 0.898 0.933 0.135
ENSG00000128881 E019 0.2934659 0.0286556323 4.227639e-01   15 42855119 42855200 82 - 0.072 0.199 1.681
ENSG00000128881 E020 0.2998086 0.0285535569 4.227626e-01   15 42857395 42857516 122 - 0.072 0.199 1.681
ENSG00000128881 E021 5.9212681 0.0033350981 2.191848e-01 3.493895e-01 15 42872611 42872677 67 - 0.744 0.933 0.739
ENSG00000128881 E022 4.4380576 0.0038630484 2.708489e-01 4.095063e-01 15 42872678 42872696 19 - 0.648 0.834 0.755
ENSG00000128881 E023 5.8689556 0.0028561241 2.183490e-01 3.484208e-01 15 42872697 42872758 62 - 0.743 0.933 0.739
ENSG00000128881 E024 10.1225928 0.0052008574 9.369121e-01 9.643333e-01 15 42878549 42878684 136 - 0.996 1.014 0.069
ENSG00000128881 E025 0.1451727 0.0439170202 1.000000e+00   15 42908216 42908275 60 - 0.072 0.000 -7.745
ENSG00000128881 E026 10.5242784 0.0705009817 1.698580e-01 2.880282e-01 15 42919759 42919912 154 - 0.936 1.197 0.952
ENSG00000128881 E027 7.9961089 0.0116020963 8.266553e-01 8.909211e-01 15 42920438 42920809 372 - 0.908 0.904 -0.016