ENSG00000128872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000249700 ENSG00000128872 HEK293_OSMI2_2hA HEK293_TMG_2hB TMOD2 protein_coding protein_coding 1.827901 0.7360681 2.69054 0.1177793 0.02402232 1.855869 1.28382799 0.18214009 2.3074078 0.08096234 0.09986504 3.592281 0.62602917 0.26833333 0.85790000 0.58956667 1.076334e-03 2.024962e-15 FALSE TRUE
ENST00000435126 ENSG00000128872 HEK293_OSMI2_2hA HEK293_TMG_2hB TMOD2 protein_coding protein_coding 1.827901 0.7360681 2.69054 0.1177793 0.02402232 1.855869 0.06833821 0.09381726 0.0000000 0.09381726 0.00000000 -3.375974 0.03024583 0.09816667 0.00000000 -0.09816667 4.833268e-01 2.024962e-15 FALSE TRUE
ENST00000561407 ENSG00000128872 HEK293_OSMI2_2hA HEK293_TMG_2hB TMOD2 protein_coding nonsense_mediated_decay 1.827901 0.7360681 2.69054 0.1177793 0.02402232 1.855869 0.11253278 0.37763737 0.0000000 0.08856677 0.00000000 -5.276636 0.13531667 0.50346667 0.00000000 -0.50346667 2.024962e-15 2.024962e-15 TRUE FALSE
MSTRG.10814.4 ENSG00000128872 HEK293_OSMI2_2hA HEK293_TMG_2hB TMOD2 protein_coding   1.827901 0.7360681 2.69054 0.1177793 0.02402232 1.855869 0.23264331 0.04871140 0.2151793 0.04871140 0.10760635 1.939362 0.14053750 0.08813333 0.08003333 -0.00810000 9.067958e-01 2.024962e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128872 E001 0.6569633 0.4499885670 6.172128e-01 7.350796e-01 15 51751590 51751596 7 + 0.160 0.238 0.716
ENSG00000128872 E002 1.3912458 0.0173441530 6.113565e-01 7.304607e-01 15 51751597 51751611 15 + 0.341 0.233 -0.747
ENSG00000128872 E003 1.9866984 0.0389511836 3.361807e-01 4.799972e-01 15 51751612 51751614 3 + 0.445 0.233 -1.329
ENSG00000128872 E004 6.1627031 0.0032283556 3.578829e-01 5.023088e-01 15 51751615 51751666 52 + 0.804 0.658 -0.598
ENSG00000128872 E005 7.4234494 0.0022275465 8.366649e-01 8.978597e-01 15 51751667 51751712 46 + 0.852 0.825 -0.107
ENSG00000128872 E006 14.1774389 0.0012816242 2.294635e-01 3.617914e-01 15 51766373 51766567 195 + 1.117 0.979 -0.504
ENSG00000128872 E007 0.1472490 0.0424939776 1.000000e+00   15 51766568 51767070 503 + 0.060 0.001 -6.880
ENSG00000128872 E008 0.1515154 0.0424832167 1.000000e+00   15 51767071 51767152 82 + 0.060 0.001 -6.880
ENSG00000128872 E009 12.9331640 0.0104355313 2.926860e-01 4.336656e-01 15 51768262 51768418 157 + 1.080 0.945 -0.497
ENSG00000128872 E010 10.5582802 0.0082168975 4.032865e-02 9.163370e-02 15 51773712 51773834 123 + 1.023 0.721 -1.164
ENSG00000128872 E011 10.6983187 0.0017139794 7.069853e-02 1.445023e-01 15 51776932 51777018 87 + 1.023 0.776 -0.942
ENSG00000128872 E012 6.1418647 0.0029956170 5.938676e-02 1.255905e-01 15 51781044 51781048 5 + 0.824 0.495 -1.413
ENSG00000128872 E013 12.2217356 0.0015618094 2.059531e-01 3.336172e-01 15 51781049 51781174 126 + 1.064 0.908 -0.577
ENSG00000128872 E014 10.7940599 0.0047506092 2.828351e-02 6.856863e-02 15 51782721 51782821 101 + 1.035 0.721 -1.209
ENSG00000128872 E015 5.5359168 0.0029065193 1.023870e-01 1.941594e-01 15 51782822 51782828 7 + 0.783 0.495 -1.252
ENSG00000128872 E016 0.4470576 0.0230351038 4.822499e-01 6.204107e-01 15 51782829 51783136 308 + 0.113 0.233 1.248
ENSG00000128872 E017 1.6480899 0.0099581059 9.653061e-02 1.851585e-01 15 51783429 51784980 1552 + 0.278 0.585 1.667
ENSG00000128872 E018 11.5125459 0.0014789593 3.074108e-01 4.496424e-01 15 51798197 51798340 144 + 1.035 0.908 -0.472
ENSG00000128872 E019 12.4119477 0.0015482210 1.016678e-01 1.930333e-01 15 51806377 51806521 145 + 1.075 0.869 -0.769
ENSG00000128872 E020 6.0851589 0.0031883727 5.973592e-02 1.261738e-01 15 51808420 51808450 31 + 0.824 0.495 -1.413
ENSG00000128872 E021 8.6756508 0.0020557078 7.397911e-01 8.294051e-01 15 51808451 51808544 94 + 0.912 0.869 -0.165
ENSG00000128872 E022 35.1657553 0.0204512909 9.662420e-02 1.852993e-01 15 51808545 51809445 901 + 1.491 1.325 -0.573
ENSG00000128872 E023 19.9626650 0.0009931455 2.106752e-03 7.554899e-03 15 51809446 51810178 733 + 1.283 0.945 -1.221
ENSG00000128872 E024 235.5310155 0.0006054086 5.047782e-14 1.498178e-12 15 51810179 51816363 6185 + 2.247 2.387 0.469