ENSG00000128829

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263791 ENSG00000128829 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2AK4 protein_coding protein_coding 13.5072 9.327064 16.86036 0.7290225 0.2198221 0.8534499 8.9760317 4.14894384 13.6537312 0.46995292 0.28345602 1.716062 0.63313750 0.448933333 0.809766667 0.36083333 6.485549e-07 6.485549e-07 FALSE TRUE
ENST00000558557 ENSG00000128829 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2AK4 protein_coding retained_intron 13.5072 9.327064 16.86036 0.7290225 0.2198221 0.8534499 0.5185142 1.00077283 0.0000000 0.52997150 0.00000000 -6.659315 0.05314583 0.103133333 0.000000000 -0.10313333 9.654669e-02 6.485549e-07 FALSE TRUE
ENST00000558823 ENSG00000128829 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2AK4 protein_coding protein_coding 13.5072 9.327064 16.86036 0.7290225 0.2198221 0.8534499 0.4038216 1.18062629 0.1121456 0.50573720 0.06680111 -3.285046 0.03759583 0.121133333 0.006666667 -0.11446667 5.259748e-03 6.485549e-07   FALSE
ENST00000560855 ENSG00000128829 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2AK4 protein_coding protein_coding 13.5072 9.327064 16.86036 0.7290225 0.2198221 0.8534499 0.9989305 1.43092697 0.1053752 0.37872391 0.05268797 -3.642592 0.08447083 0.159600000 0.006300000 -0.15330000 1.621553e-04 6.485549e-07 FALSE TRUE
ENST00000624709 ENSG00000128829 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2AK4 protein_coding TEC 13.5072 9.327064 16.86036 0.7290225 0.2198221 0.8534499 1.4266636 1.22145122 1.1306526 0.17594162 0.11659378 -0.110500 0.11248333 0.129700000 0.066933333 -0.06276667 7.401070e-03 6.485549e-07   FALSE
MSTRG.10536.2 ENSG00000128829 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF2AK4 protein_coding   13.5072 9.327064 16.86036 0.7290225 0.2198221 0.8534499 0.8671301 0.03891974 1.4208417 0.03891974 0.18344636 4.870303 0.05291250 0.004433333 0.084400000 0.07996667 2.833803e-05 6.485549e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128829 E001 2.2689028 0.0333042529 2.360344e-02 5.899444e-02 15 39934115 39934132 18 + 0.613 0.170 -2.698
ENSG00000128829 E002 4.2200131 0.0038276307 1.607162e-03 5.984473e-03 15 39934133 39934145 13 + 0.830 0.291 -2.590
ENSG00000128829 E003 15.7075853 0.0011349885 1.355617e-02 3.720537e-02 15 39934146 39934175 30 + 1.272 1.043 -0.819
ENSG00000128829 E004 45.7999269 0.0044528340 3.392029e-06 2.509802e-05 15 39934176 39934339 164 + 1.739 1.429 -1.059
ENSG00000128829 E005 55.8421294 0.0069194752 6.357482e-05 3.489413e-04 15 39939505 39939617 113 + 1.813 1.550 -0.894
ENSG00000128829 E006 61.4262892 0.0004441854 1.838211e-07 1.774309e-06 15 39943383 39943485 103 + 1.854 1.594 -0.881
ENSG00000128829 E007 3.0290010 0.0052186878 4.201242e-02 9.474700e-02 15 39946589 39946895 307 + 0.443 0.762 1.432
ENSG00000128829 E008 73.6951863 0.0003247554 6.703814e-05 3.658095e-04 15 39949116 39949268 153 + 1.911 1.737 -0.587
ENSG00000128829 E009 48.4864345 0.0145761304 6.456377e-02 1.343165e-01 15 39953904 39953974 71 + 1.726 1.589 -0.466
ENSG00000128829 E010 33.5394461 0.0032189602 3.573802e-02 8.307722e-02 15 39953975 39953984 10 + 1.569 1.428 -0.485
ENSG00000128829 E011 80.9455286 0.0003327627 4.080149e-04 1.805124e-03 15 39955620 39955768 149 + 1.943 1.797 -0.490
ENSG00000128829 E012 79.1362408 0.0016197367 6.809560e-03 2.072737e-02 15 39961784 39961899 116 + 1.925 1.804 -0.406
ENSG00000128829 E013 94.8087639 0.0003289699 1.492059e-03 5.610681e-03 15 39965686 39965843 158 + 2.003 1.884 -0.400
ENSG00000128829 E014 193.7479703 0.0004225495 2.987206e-04 1.374453e-03 15 39967344 39967879 536 + 2.305 2.210 -0.319
ENSG00000128829 E015 67.6559735 0.0005412457 2.591645e-01 3.965398e-01 15 39972908 39973014 107 + 1.839 1.794 -0.153
ENSG00000128829 E016 86.2975893 0.0003385472 5.169023e-01 6.514042e-01 15 39973592 39973749 158 + 1.930 1.910 -0.067
ENSG00000128829 E017 2.1295898 0.0070584518 2.924317e-01 4.333972e-01 15 39973750 39975429 1680 + 0.407 0.588 0.888
ENSG00000128829 E018 109.2761393 0.0053173201 8.011697e-02 1.597356e-01 15 39976414 39976844 431 + 2.051 1.969 -0.273
ENSG00000128829 E019 37.9574008 0.0091902977 5.657950e-09 7.313602e-08 15 39976979 39978077 1099 + 1.373 1.803 1.468
ENSG00000128829 E020 48.5032659 0.0102694712 3.012563e-03 1.030276e-02 15 39978078 39978147 70 + 1.746 1.534 -0.722
ENSG00000128829 E021 1.3233011 0.0097426223 8.048828e-02 1.603190e-01 15 39978148 39978292 145 + 0.221 0.530 1.847
ENSG00000128829 E022 65.2812309 0.0073605397 1.339471e-03 5.108072e-03 15 39985805 39985888 84 + 1.867 1.669 -0.670
ENSG00000128829 E023 94.4046310 0.0003241758 6.614789e-10 1.014945e-08 15 39987983 39988105 123 + 2.035 1.787 -0.835
ENSG00000128829 E024 89.7501304 0.0035698292 3.122017e-03 1.062491e-02 15 39990273 39990377 105 + 1.984 1.842 -0.478
ENSG00000128829 E025 0.5848434 0.0238645046 1.680495e-01 2.856660e-01 15 39991166 39992174 1009 + 0.275 0.000 -12.072
ENSG00000128829 E026 75.6375876 0.0054714193 2.973593e-02 7.143885e-02 15 39992175 39992229 55 + 1.902 1.783 -0.403
ENSG00000128829 E027 0.8211642 0.1503441166 6.241205e-01 7.405596e-01 15 39992230 39992768 539 + 0.276 0.171 -0.878
ENSG00000128829 E028 81.4222601 0.0009817763 1.098047e-01 2.052751e-01 15 39992769 39992848 80 + 1.918 1.853 -0.217
ENSG00000128829 E029 86.0858004 0.0015529712 2.105720e-02 5.371494e-02 15 39996964 39997065 102 + 1.953 1.856 -0.327
ENSG00000128829 E030 65.4767577 0.0005254988 1.374469e-02 3.764044e-02 15 39998731 39998784 54 + 1.840 1.729 -0.375
ENSG00000128829 E031 117.2181427 0.0004487090 2.033492e-02 5.218555e-02 15 40000988 40001224 237 + 2.082 2.006 -0.256
ENSG00000128829 E032 0.0000000       15 40002391 40002510 120 +      
ENSG00000128829 E033 0.1817044 0.0394303477 2.282753e-01   15 40002511 40002712 202 + 0.000 0.170 12.018
ENSG00000128829 E034 63.1042253 0.0004016375 4.160595e-02 9.401274e-02 15 40002713 40002788 76 + 1.823 1.733 -0.306
ENSG00000128829 E035 65.5697105 0.0008543970 3.798834e-01 5.241454e-01 15 40003193 40003314 122 + 1.822 1.787 -0.118
ENSG00000128829 E036 43.2873695 0.0005328313 8.734315e-01 9.226603e-01 15 40007016 40007065 50 + 1.632 1.629 -0.010
ENSG00000128829 E037 99.1624156 0.0007328587 3.423196e-01 4.863139e-01 15 40008027 40008195 169 + 1.992 1.961 -0.105
ENSG00000128829 E038 95.6146643 0.0002973630 8.406477e-01 9.005468e-01 15 40009614 40009730 117 + 1.967 1.965 -0.006
ENSG00000128829 E039 72.6765618 0.0003538807 1.110711e-01 2.071153e-01 15 40011281 40011346 66 + 1.823 1.897 0.249
ENSG00000128829 E040 99.0654181 0.0024786712 2.327755e-01 3.657342e-01 15 40016502 40016672 171 + 1.963 2.020 0.191
ENSG00000128829 E041 85.2959100 0.0007278910 1.726318e-02 4.553179e-02 15 40017108 40017242 135 + 1.883 1.985 0.343
ENSG00000128829 E042 88.3141926 0.0004889719 2.016310e-02 5.182604e-02 15 40019093 40019200 108 + 1.899 1.995 0.325
ENSG00000128829 E043 0.5911862 0.0172671820 1.661563e-01 2.832037e-01 15 40020526 40020898 373 + 0.276 0.000 -12.072
ENSG00000128829 E044 115.1273922 0.0023711038 2.911253e-03 1.000323e-02 15 40020899 40021027 129 + 2.000 2.126 0.421
ENSG00000128829 E045 1.0780097 0.0535687322 5.745506e-01 7.003402e-01 15 40021543 40022518 976 + 0.276 0.385 0.686
ENSG00000128829 E046 113.8571819 0.0003292429 1.087586e-02 3.087110e-02 15 40022519 40022605 87 + 2.010 2.103 0.312
ENSG00000128829 E047 115.2632920 0.0002529393 1.206218e-03 4.661371e-03 15 40025977 40026089 113 + 2.004 2.119 0.386
ENSG00000128829 E048 80.3430174 0.0028662662 2.501362e-03 8.767030e-03 15 40029406 40029464 59 + 1.836 1.982 0.493
ENSG00000128829 E049 63.6144219 0.0004749918 3.164171e-05 1.872381e-04 15 40030359 40030392 34 + 1.712 1.905 0.652
ENSG00000128829 E050 94.9110420 0.0002844184 1.133410e-09 1.663860e-08 15 40030393 40030456 64 + 1.867 2.096 0.769
ENSG00000128829 E051 87.8518905 0.0003375188 1.095705e-10 1.920595e-09 15 40032169 40032237 69 + 1.826 2.077 0.844
ENSG00000128829 E052 67.6973338 0.0046670440 1.673351e-05 1.056247e-04 15 40032757 40032801 45 + 1.721 1.957 0.795
ENSG00000128829 E053 83.9179580 0.0015519198 1.488419e-10 2.549977e-09 15 40034326 40034444 119 + 1.792 2.068 0.930
ENSG00000128829 E054 130.8927443 0.0074736840 3.275932e-13 8.653311e-12 15 40035027 40035591 565 + 1.928 2.308 1.273