ENSG00000128791

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262120 ENSG00000128791 HEK293_OSMI2_2hA HEK293_TMG_2hB TWSG1 protein_coding protein_coding 10.85912 2.798503 18.86522 0.3016655 0.4385039 2.74862 10.34556 2.769299 17.71951 0.27383 0.275015 2.67336 0.9500417 0.9913333 0.9396 -0.05173333 0.02257761 0.02257761 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128791 E001 1.4769841 0.0089826466 1.701803e-01 2.884198e-01 18 9334767 9334772 6 + 0.348 0.000 -10.838
ENSG00000128791 E002 21.0181543 0.0009141413 2.400384e-05 1.462392e-04 18 9334773 9334849 77 + 1.248 0.726 -1.950
ENSG00000128791 E003 45.0836919 0.0005755964 1.077955e-02 3.063765e-02 18 9334850 9334920 71 + 1.536 1.401 -0.465
ENSG00000128791 E004 102.7887322 0.0003951808 8.046800e-04 3.275763e-03 18 9337193 9337352 160 + 1.882 1.776 -0.357
ENSG00000128791 E005 98.0628003 0.0003186643 1.358608e-01 2.422942e-01 18 9359972 9360071 100 + 1.849 1.840 -0.031
ENSG00000128791 E006 1.9845083 0.0116451557 4.816162e-01 6.198167e-01 18 9388040 9388140 101 + 0.393 0.270 -0.768
ENSG00000128791 E007 0.7427016 0.0155766876 5.311734e-01 6.636723e-01 18 9388364 9388420 57 + 0.208 0.000 -9.837
ENSG00000128791 E008 156.6291264 0.0002356767 6.475550e-06 4.493841e-05 18 9396280 9396546 267 + 2.064 1.945 -0.397
ENSG00000128791 E009 2.2259267 0.0065356586 9.229170e-01 9.553839e-01 18 9396547 9397067 521 + 0.414 0.435 0.113
ENSG00000128791 E010 720.7175806 0.0033274386 5.513883e-09 7.141509e-08 18 9399346 9402420 3075 + 2.685 2.829 0.481