ENSG00000128789

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317615 ENSG00000128789 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMG2 protein_coding protein_coding 31.59563 34.71109 34.39711 2.290764 1.635503 -0.01310543 21.648536 22.668212 24.2657457 1.79738782 1.8644485 0.0982087 0.67394583 0.65200000 0.7034333 0.051433333 3.675613e-01 1.905858e-09 FALSE  
ENST00000586587 ENSG00000128789 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMG2 protein_coding nonsense_mediated_decay 31.59563 34.71109 34.39711 2.290764 1.635503 -0.01310543 1.665255 1.674729 1.3254816 0.19881198 0.9367159 -0.3351568 0.05519167 0.04823333 0.0409000 -0.007333333 7.331158e-01 1.905858e-09 TRUE  
ENST00000590217 ENSG00000128789 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMG2 protein_coding protein_coding 31.59563 34.71109 34.39711 2.290764 1.635503 -0.01310543 4.256575 2.965259 5.7354241 0.40131692 0.2285366 0.9493982 0.13027917 0.08466667 0.1669667 0.082300000 1.740090e-06 1.905858e-09 FALSE  
MSTRG.15523.2 ENSG00000128789 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMG2 protein_coding   31.59563 34.71109 34.39711 2.290764 1.635503 -0.01310543 1.502568 3.278704 0.8620617 0.09851439 0.1131891 -1.9150169 0.05214583 0.09553333 0.0250000 -0.070533333 1.905858e-09 1.905858e-09    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128789 E001 0.5159433 0.2739865112 5.921637e-01 7.147686e-01 18 12658043 12658129 87 + 0.228 0.118 -1.142
ENSG00000128789 E002 5.8424416 0.0944445046 2.705535e-02 6.610634e-02 18 12658130 12658192 63 + 0.574 0.954 1.537
ENSG00000128789 E003 7.7160527 0.0071937112 8.484007e-04 3.432137e-03 18 12658193 12658205 13 + 0.648 1.070 1.638
ENSG00000128789 E004 16.6428539 0.0098602414 1.120817e-04 5.774222e-04 18 12658206 12658245 40 + 0.984 1.364 1.358
ENSG00000128789 E005 24.6268025 0.0009260996 1.676934e-07 1.631523e-06 18 12658246 12658343 98 + 1.139 1.529 1.363
ENSG00000128789 E006 0.2903454 0.2755737603 2.419334e-01   18 12658551 12658573 23 + 0.227 0.000 -9.563
ENSG00000128789 E007 47.7920495 0.0005611526 3.234458e-16 1.305964e-14 18 12658574 12658737 164 + 1.370 1.824 1.549
ENSG00000128789 E008 26.5841067 0.0010736972 6.787062e-10 1.039021e-08 18 12658738 12658773 36 + 1.117 1.574 1.596
ENSG00000128789 E009 2.8407755 0.0057714916 2.024246e-03 7.302017e-03 18 12658774 12658893 120 + 0.228 0.748 2.735
ENSG00000128789 E010 20.1718050 0.0010363280 5.944215e-14 1.744831e-12 18 12663458 12663738 281 + 0.814 1.497 2.460
ENSG00000128789 E011 6.0042159 0.0931612741 6.007109e-01 7.219116e-01 18 12665065 12665139 75 + 0.790 0.883 0.364
ENSG00000128789 E012 4.4898950 0.0036678151 3.277799e-03 1.108537e-02 18 12686275 12686491 217 + 0.435 0.872 1.901
ENSG00000128789 E013 1.5791897 0.0867526180 8.498952e-01 9.068488e-01 18 12686653 12686752 100 + 0.377 0.408 0.173
ENSG00000128789 E014 16.0670590 0.0011948396 4.128967e-05 2.372306e-04 18 12703023 12703025 3 + 1.395 1.046 -1.233
ENSG00000128789 E015 43.8069225 0.0045934286 2.268072e-03 8.054274e-03 18 12703026 12703041 16 + 1.744 1.556 -0.640
ENSG00000128789 E016 160.2475094 0.0021311511 1.151054e-05 7.542326e-05 18 12703042 12703164 123 + 2.285 2.136 -0.500
ENSG00000128789 E017 257.2783907 0.0004252661 5.530502e-06 3.898266e-05 18 12706550 12706721 172 + 2.466 2.363 -0.342
ENSG00000128789 E018 146.1079087 0.0002338966 1.274813e-01 2.306505e-01 18 12712702 12712760 59 + 2.190 2.144 -0.154
ENSG00000128789 E019 206.9468664 0.0002466771 8.260835e-01 8.905552e-01 18 12718517 12718635 119 + 2.319 2.311 -0.026
ENSG00000128789 E020 265.6441369 0.0002215985 9.307162e-02 1.799235e-01 18 12720510 12720683 174 + 2.405 2.437 0.108
ENSG00000128789 E021 5.6947096 0.0029982678 2.461139e-01 3.813900e-01 18 12724128 12724498 371 + 0.898 0.748 -0.584
ENSG00000128789 E022 222.7207379 0.0003065981 7.849709e-01 8.621292e-01 18 12724499 12724619 121 + 2.354 2.346 -0.028
ENSG00000128789 E023 3.8804463 1.0639410814 4.943172e-01 6.312735e-01 18 12724620 12724868 249 + 0.744 0.647 -0.402
ENSG00000128789 E024 215.4886045 0.0009912500 9.640522e-01 9.813326e-01 18 12725439 12725740 302 + 2.337 2.334 -0.009