ENSG00000128731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261609 ENSG00000128731 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2 protein_coding protein_coding 19.14768 25.3986 12.70524 1.582508 0.7797853 -0.9987589 4.6370200 3.6664291 4.604824 0.6598419 0.3726393 0.3279706 0.26481250 0.1455667 0.36163333 0.21606667 2.196347e-04 4.977689e-06 FALSE TRUE
ENST00000562136 ENSG00000128731 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2 protein_coding retained_intron 19.14768 25.3986 12.70524 1.582508 0.7797853 -0.9987589 5.0710589 8.9162972 1.969420 0.3977219 0.3733603 -2.1729841 0.24508333 0.3518000 0.15306667 -0.19873333 4.977689e-06 4.977689e-06 FALSE TRUE
ENST00000563945 ENSG00000128731 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2 protein_coding processed_transcript 19.14768 25.3986 12.70524 1.582508 0.7797853 -0.9987589 2.2933311 3.4467821 2.034813 0.1274076 0.1452482 -0.7574606 0.12888333 0.1368000 0.16136667 0.02456667 6.543880e-01 4.977689e-06 FALSE FALSE
ENST00000564383 ENSG00000128731 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2 protein_coding retained_intron 19.14768 25.3986 12.70524 1.582508 0.7797853 -0.9987589 0.9256639 0.6997912 1.200870 0.3623413 0.2438471 0.7705776 0.05460417 0.0279000 0.09533333 0.06743333 1.036245e-01 4.977689e-06 FALSE TRUE
ENST00000650509 ENSG00000128731 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC2 protein_coding nonsense_mediated_decay 19.14768 25.3986 12.70524 1.582508 0.7797853 -0.9987589 5.2535028 7.7131637 2.290134 0.8627476 0.2574559 -1.7474739 0.25302500 0.3019000 0.17926667 -0.12263333 4.954761e-04 4.977689e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128731 E001 3.6053196 0.0053333660 5.701513e-02 1.214863e-01 15 28111040 28111078 39 - 0.410 0.726 1.457
ENSG00000128731 E002 45.4916638 0.0067679326 2.797291e-13 7.470234e-12 15 28111079 28111278 200 - 1.213 1.782 1.959
ENSG00000128731 E003 247.5520452 0.0224907192 1.866082e-06 1.461687e-05 15 28111279 28111761 483 - 2.094 2.482 1.294
ENSG00000128731 E004 233.8152854 0.0067445675 1.600110e-08 1.898992e-07 15 28111762 28112035 274 - 2.150 2.434 0.949
ENSG00000128731 E005 190.1375074 0.0036088464 5.571398e-09 7.210580e-08 15 28113071 28113283 213 - 2.087 2.334 0.828
ENSG00000128731 E006 113.8851105 0.0020075512 1.689838e-08 1.996973e-07 15 28113573 28113678 106 - 1.863 2.111 0.833
ENSG00000128731 E007 1.0255820 0.4177170519 9.899774e-01 9.978382e-01 15 28113679 28113717 39 - 0.252 0.320 0.469
ENSG00000128731 E008 156.1056836 0.0002785891 5.963679e-13 1.517326e-11 15 28114612 28114802 191 - 2.007 2.243 0.790
ENSG00000128731 E009 0.0000000       15 28115281 28115428 148 -      
ENSG00000128731 E010 116.3408758 0.0003120507 1.276273e-12 3.076551e-11 15 28115429 28115541 113 - 1.856 2.125 0.904
ENSG00000128731 E011 131.6192072 0.0004755472 3.167373e-09 4.278426e-08 15 28116665 28116859 195 - 1.953 2.167 0.716
ENSG00000128731 E012 2.1818282 0.1362517140 5.738208e-01 6.997343e-01 15 28116860 28117012 153 - 0.575 0.454 -0.577
ENSG00000128731 E013 108.2949695 0.0015642803 5.856431e-06 4.105548e-05 15 28117013 28117154 142 - 1.881 2.078 0.661
ENSG00000128731 E014 8.4016225 0.0474919871 5.982330e-01 7.198792e-01 15 28117155 28118421 1267 - 0.984 0.925 -0.221
ENSG00000128731 E015 93.4258847 0.0097729343 8.068734e-03 2.395470e-02 15 28121346 28121429 84 - 1.834 2.013 0.604
ENSG00000128731 E016 136.0241342 0.0058562974 1.937637e-03 7.033388e-03 15 28124037 28124234 198 - 2.005 2.171 0.555
ENSG00000128731 E017 136.3256439 0.0029369739 5.209490e-03 1.650123e-02 15 28125006 28125193 188 - 2.035 2.160 0.421
ENSG00000128731 E018 116.3781976 0.0005231006 1.343411e-04 6.782827e-04 15 28130163 28130299 137 - 1.950 2.096 0.491
ENSG00000128731 E019 54.0138189 0.0010905936 2.052836e-03 7.390093e-03 15 28130300 28130302 3 - 1.605 1.776 0.580
ENSG00000128731 E020 95.4071149 0.0019401190 7.426973e-06 5.081688e-05 15 28130503 28130594 92 - 1.821 2.029 0.697
ENSG00000128731 E021 119.9752592 0.0018206214 4.988048e-04 2.155597e-03 15 28132100 28132261 162 - 1.961 2.109 0.497
ENSG00000128731 E022 0.6695470 0.0205086757 5.315563e-01 6.639836e-01 15 28132262 28132397 136 - 0.144 0.257 1.039
ENSG00000128731 E023 123.1953517 0.0007305406 2.839426e-04 1.314599e-03 15 28132653 28132830 178 - 1.977 2.117 0.467
ENSG00000128731 E024 131.5528188 0.0026171782 1.637439e-02 4.355262e-02 15 28135478 28135692 215 - 2.028 2.136 0.362
ENSG00000128731 E025 123.1507484 0.0005871016 2.085431e-02 5.328099e-02 15 28141432 28141630 199 - 2.010 2.100 0.302
ENSG00000128731 E026 52.0812826 0.0036837223 7.117100e-01 8.086321e-01 15 28141731 28141738 8 - 1.676 1.710 0.115
ENSG00000128731 E027 89.6226607 0.0003604969 3.634840e-02 8.424491e-02 15 28141739 28141846 108 - 1.870 1.962 0.310
ENSG00000128731 E028 78.9818519 0.0003305633 3.805333e-03 1.259567e-02 15 28142238 28142393 156 - 1.792 1.923 0.442
ENSG00000128731 E029 0.1515154 0.0421091120 3.340747e-01   15 28142394 28142452 59 - 0.144 0.000 -10.546
ENSG00000128731 E030 55.2987542 0.0076482145 9.344764e-02 1.805067e-01 15 28142827 28142952 126 - 1.646 1.770 0.422
ENSG00000128731 E031 60.7215249 0.0004468799 9.263581e-01 9.576286e-01 15 28143873 28143991 119 - 1.757 1.771 0.045
ENSG00000128731 E032 72.6419848 0.0026336275 9.658634e-01 9.825323e-01 15 28144077 28144235 159 - 1.834 1.846 0.042
ENSG00000128731 E033 71.8067013 0.0014799758 3.039109e-01 4.458859e-01 15 28144673 28144804 132 - 1.803 1.859 0.190
ENSG00000128731 E034 75.1812726 0.0051224540 5.444222e-01 6.748943e-01 15 28146237 28146344 108 - 1.875 1.852 -0.076
ENSG00000128731 E035 64.1532089 0.0013821130 8.237188e-01 8.889287e-01 15 28152677 28152758 82 - 1.778 1.798 0.068
ENSG00000128731 E036 50.6110487 0.0066311506 6.612106e-01 7.697161e-01 15 28152759 28152830 72 - 1.704 1.686 -0.059
ENSG00000128731 E037 80.2905175 0.0010596465 1.757214e-01 2.956238e-01 15 28163094 28163285 192 - 1.844 1.912 0.230
ENSG00000128731 E038 66.0876151 0.0007678044 8.451413e-01 9.036646e-01 15 28167687 28167827 141 - 1.789 1.807 0.061
ENSG00000128731 E039 75.7607772 0.0020049025 9.863218e-01 9.954807e-01 15 28168407 28168590 184 - 1.851 1.862 0.038
ENSG00000128731 E040 69.9797067 0.0074716683 8.147907e-01 8.826453e-01 15 28169484 28169655 172 - 1.824 1.827 0.011
ENSG00000128731 E041 78.9313892 0.0025367408 9.847319e-01 9.945118e-01 15 28174395 28174620 226 - 1.870 1.880 0.036
ENSG00000128731 E042 70.3547044 0.0017229144 9.198974e-01 9.534042e-01 15 28175512 28175656 145 - 1.819 1.833 0.050
ENSG00000128731 E043 80.9608426 0.0003413583 3.592801e-01 5.036184e-01 15 28176428 28176599 172 - 1.907 1.879 -0.095
ENSG00000128731 E044 61.8766478 0.0004136327 2.170385e-01 3.468152e-01 15 28176687 28176768 82 - 1.808 1.760 -0.161
ENSG00000128731 E045 86.0608184 0.0007764045 1.108964e-01 2.068669e-01 15 28176950 28177127 178 - 1.950 1.895 -0.184
ENSG00000128731 E046 67.8178507 0.0006133111 1.822996e-01 3.040953e-01 15 28177419 28177509 91 - 1.846 1.796 -0.170
ENSG00000128731 E047 74.0344029 0.0004509020 1.685508e-01 2.862774e-01 15 28178887 28179030 144 - 1.881 1.832 -0.166
ENSG00000128731 E048 49.7672905 0.0004805478 1.452189e-02 3.941501e-02 15 28179142 28179223 82 - 1.751 1.637 -0.389
ENSG00000128731 E049 57.8314268 0.0004262494 1.252386e-02 3.479448e-02 15 28182401 28182512 112 - 1.811 1.702 -0.368
ENSG00000128731 E050 72.4816808 0.0004455090 7.456971e-01 8.336682e-01 15 28186577 28186752 176 - 1.844 1.839 -0.017
ENSG00000128731 E051 0.1515154 0.0421091120 3.340747e-01   15 28190201 28190964 764 - 0.144 0.000 -10.546
ENSG00000128731 E052 45.4956780 0.0074632457 8.478585e-01 9.055287e-01 15 28190965 28191056 92 - 1.646 1.643 -0.008
ENSG00000128731 E053 38.3112090 0.0036352306 3.288910e-01 4.723802e-01 15 28191139 28191244 106 - 1.601 1.549 -0.177
ENSG00000128731 E054 51.7992848 0.0063718743 9.209230e-01 9.541154e-01 15 28191961 28192151 191 - 1.693 1.700 0.022
ENSG00000128731 E055 50.1747144 0.0036535589 6.505618e-01 7.615877e-01 15 28196215 28196354 140 - 1.657 1.696 0.130
ENSG00000128731 E056 47.1234942 0.0095385849 9.008645e-01 9.407755e-01 15 28196461 28196569 109 - 1.654 1.661 0.026
ENSG00000128731 E057 54.0344019 0.0040154852 2.358436e-02 5.895685e-02 15 28198378 28198503 126 - 1.789 1.672 -0.395
ENSG00000128731 E058 68.6290880 0.0258593562 1.323093e-01 2.373210e-01 15 28198601 28198769 169 - 1.888 1.783 -0.355
ENSG00000128731 E059 48.0682885 0.0106032422 6.607704e-04 2.755227e-03 15 28201456 28201554 99 - 1.800 1.576 -0.760
ENSG00000128731 E060 36.5621370 0.0072692840 1.728410e-03 6.372413e-03 15 28202113 28202249 137 - 1.676 1.468 -0.707
ENSG00000128731 E061 22.0609743 0.0012711248 1.607401e-02 4.290065e-02 15 28202347 28202614 268 - 1.443 1.274 -0.587
ENSG00000128731 E062 0.4741261 0.0222705611 3.618332e-01 5.062496e-01 15 28202615 28203936 1322 - 0.252 0.104 -1.544
ENSG00000128731 E063 10.7986906 0.0016503178 9.352607e-01 9.632347e-01 15 28206240 28206382 143 - 1.034 1.051 0.061
ENSG00000128731 E064 22.6963202 0.0014490663 4.349979e-01 5.772305e-01 15 28211002 28211145 144 - 1.377 1.327 -0.171
ENSG00000128731 E065 24.5120818 0.0035984342 4.254175e-01 5.683684e-01 15 28212445 28212583 139 - 1.411 1.360 -0.176
ENSG00000128731 E066 41.4117381 0.0064858726 4.317286e-02 9.686245e-02 15 28213742 28213972 231 - 1.679 1.556 -0.419
ENSG00000128731 E067 32.0607634 0.0203926574 7.434966e-02 1.504987e-01 15 28214076 28214272 197 - 1.579 1.439 -0.481
ENSG00000128731 E068 24.9677130 0.0062990034 2.688171e-01 4.072890e-01 15 28214655 28214802 148 - 1.437 1.361 -0.263
ENSG00000128731 E069 28.4685432 0.0006834009 8.316488e-03 2.458353e-02 15 28215621 28215802 182 - 1.546 1.383 -0.561
ENSG00000128731 E070 31.1853817 0.0038384364 1.442177e-03 5.446920e-03 15 28218489 28218671 183 - 1.605 1.399 -0.708
ENSG00000128731 E071 36.7304159 0.0217539221 4.977018e-04 2.151420e-03 15 28220452 28220644 193 - 1.720 1.421 -1.020
ENSG00000128731 E072 25.0658531 0.0436081529 9.512128e-03 2.756726e-02 15 28222028 28222147 120 - 1.556 1.263 -1.013
ENSG00000128731 E073 17.5591312 0.0562365044 4.070228e-02 9.232802e-02 15 28222148 28222215 68 - 1.404 1.121 -0.994
ENSG00000128731 E074 34.3509917 0.0372366539 1.090661e-01 2.041683e-01 15 28228218 28228409 192 - 1.618 1.464 -0.526
ENSG00000128731 E075 28.2299804 0.0025171083 1.589895e-02 4.250947e-02 15 28229195 28229346 152 - 1.532 1.375 -0.540
ENSG00000128731 E076 0.0000000       15 28229347 28229459 113 -      
ENSG00000128731 E077 34.3122327 0.0084379824 6.732729e-05 3.672286e-04 15 28229460 28229596 137 - 1.690 1.403 -0.980
ENSG00000128731 E078 29.7412390 0.0181417311 7.380477e-04 3.035955e-03 15 28229674 28229847 174 - 1.638 1.338 -1.030
ENSG00000128731 E079 19.2192739 0.0805822680 6.140087e-03 1.897866e-02 15 28230367 28230500 134 - 1.510 1.089 -1.475
ENSG00000128731 E080 23.9265960 0.0948843492 9.736715e-03 2.811491e-02 15 28233146 28233341 196 - 1.591 1.195 -1.376
ENSG00000128731 E081 15.4541869 0.0196941877 9.253432e-03 2.691759e-02 15 28233434 28233561 128 - 1.347 1.083 -0.937
ENSG00000128731 E082 13.8511484 0.0180421773 2.207160e-02 5.582865e-02 15 28233664 28233796 133 - 1.290 1.052 -0.850
ENSG00000128731 E083 15.5294683 0.0011442399 2.173460e-06 1.676870e-05 15 28234070 28234284 215 - 1.404 1.007 -1.411
ENSG00000128731 E084 25.2212000 0.0008221370 1.333377e-07 1.322535e-06 15 28236963 28237113 151 - 1.584 1.228 -1.231
ENSG00000128731 E085 22.7728966 0.0062478208 1.033443e-04 5.375546e-04 15 28238114 28238217 104 - 1.516 1.216 -1.043
ENSG00000128731 E086 28.6320087 0.0214495439 4.103424e-04 1.813811e-03 15 28238602 28238757 156 - 1.625 1.305 -1.104
ENSG00000128731 E087 12.5233620 0.0058864893 2.160313e-10 3.595720e-09 15 28238758 28238772 15 - 1.404 0.768 -2.326
ENSG00000128731 E088 30.2367129 0.0493575824 1.559120e-03 5.826656e-03 15 28245881 28246066 186 - 1.665 1.311 -1.216
ENSG00000128731 E089 25.8689709 0.0274272458 3.883134e-02 8.886893e-02 15 28246742 28246897 156 - 1.521 1.331 -0.657
ENSG00000128731 E090 32.8453652 0.0008149416 1.368628e-09 1.977595e-08 15 28248552 28248736 185 - 1.707 1.348 -1.230
ENSG00000128731 E091 33.2602088 0.0006372856 6.537012e-13 1.654974e-11 15 28254340 28254487 148 - 1.736 1.310 -1.462
ENSG00000128731 E092 17.2409218 0.0025807521 3.764340e-08 4.158510e-07 15 28254488 28254518 31 - 1.473 1.019 -1.604
ENSG00000128731 E093 24.0561088 0.0067626002 7.566474e-07 6.452893e-06 15 28255872 28255996 125 - 1.579 1.194 -1.336
ENSG00000128731 E094 25.2872607 0.0007355814 7.530002e-10 1.143058e-08 15 28256089 28256317 229 - 1.614 1.199 -1.435
ENSG00000128731 E095 22.3604940 0.0145869549 1.538181e-06 1.226447e-05 15 28257061 28257261 201 - 1.570 1.139 -1.503
ENSG00000128731 E096 33.5171703 0.0067178947 1.494939e-10 2.560452e-09 15 28260777 28260970 194 - 1.748 1.299 -1.540
ENSG00000128731 E097 45.7688488 0.0142952763 6.459296e-09 8.254262e-08 15 28262918 28263169 252 - 1.877 1.440 -1.486
ENSG00000128731 E098 30.0544171 0.0006379085 5.260361e-19 2.993571e-17 15 28265618 28265731 114 - 1.742 1.177 -1.952
ENSG00000128731 E099 28.5279635 0.0127857565 5.090709e-11 9.447684e-10 15 28265817 28265974 158 - 1.713 1.165 -1.896
ENSG00000128731 E100 27.4955108 0.0121573409 5.172029e-11 9.587332e-10 15 28268465 28268616 152 - 1.697 1.148 -1.899
ENSG00000128731 E101 26.2165160 0.0021235638 1.089466e-12 2.654611e-11 15 28269248 28269436 189 - 1.661 1.169 -1.704
ENSG00000128731 E102 23.3280179 0.0232249500 2.105975e-06 1.630248e-05 15 28270695 28270868 174 - 1.606 1.137 -1.629
ENSG00000128731 E103 0.0000000       15 28272044 28272214 171 -      
ENSG00000128731 E104 16.1429435 0.0056912727 6.694201e-06 4.631327e-05 15 28272215 28272386 172 - 1.424 1.030 -1.397
ENSG00000128731 E105 12.9872632 0.0013404174 1.086774e-05 7.161005e-05 15 28272894 28273004 111 - 1.331 0.932 -1.437
ENSG00000128731 E106 0.0000000       15 28273005 28273168 164 -      
ENSG00000128731 E107 13.9544538 0.0012519625 1.957431e-04 9.456557e-04 15 28274291 28274447 157 - 1.331 1.007 -1.157
ENSG00000128731 E108 10.5096192 0.0018618219 3.863862e-06 2.821015e-05 15 28274905 28275005 101 - 1.281 0.823 -1.676
ENSG00000128731 E109 6.1425338 0.1107829936 6.366024e-01 7.505812e-01 15 28280034 28280067 34 - 0.886 0.827 -0.229
ENSG00000128731 E110 33.2322684 0.0009670399 1.266802e-08 1.532124e-07 15 28280068 28280287 220 - 1.700 1.364 -1.153
ENSG00000128731 E111 30.0622037 0.0006333495 2.089431e-07 1.995747e-06 15 28292888 28293022 135 - 1.646 1.327 -1.097
ENSG00000128731 E112 0.1451727 0.0435420330 3.338327e-01   15 28298517 28298629 113 - 0.144 0.000 -10.541
ENSG00000128731 E113 21.7366955 0.0008275948 1.683122e-05 1.061742e-04 15 28299402 28299516 115 - 1.506 1.199 -1.067
ENSG00000128731 E114 37.6041181 0.0332538719 8.652187e-03 2.541327e-02 15 28320122 28320464 343 - 1.354 1.660 1.050
ENSG00000128731 E115 22.7027805 0.0172145419 3.538209e-01 4.980889e-01 15 28321362 28321464 103 - 1.411 1.330 -0.280
ENSG00000128731 E116 7.5687823 0.0025693366 7.441937e-01 8.326016e-01 15 28322075 28322179 105 - 0.885 0.932 0.176