ENSG00000128699

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392350 ENSG00000128699 HEK293_OSMI2_2hA HEK293_TMG_2hB ORMDL1 protein_coding protein_coding 49.77822 32.41971 65.51452 2.219103 0.7253793 1.014719 8.547167 5.208150 11.93924 0.34334285 0.5339579 1.1953081 0.1630042 0.16126667 0.1823000 0.02103333 0.5955976500 0.0001827915 FALSE  
ENST00000442547 ENSG00000128699 HEK293_OSMI2_2hA HEK293_TMG_2hB ORMDL1 protein_coding protein_coding 49.77822 32.41971 65.51452 2.219103 0.7253793 1.014719 3.404999 1.293230 5.33178 0.02429275 0.3954037 2.0352285 0.0668250 0.04023333 0.0813000 0.04106667 0.0001827915 0.0001827915 FALSE  
ENST00000496543 ENSG00000128699 HEK293_OSMI2_2hA HEK293_TMG_2hB ORMDL1 protein_coding processed_transcript 49.77822 32.41971 65.51452 2.219103 0.7253793 1.014719 10.849931 9.032747 12.58115 0.52256103 1.1325222 0.4775775 0.2317667 0.27923333 0.1917333 -0.08750000 0.0123086540 0.0001827915    
MSTRG.19660.10 ENSG00000128699 HEK293_OSMI2_2hA HEK293_TMG_2hB ORMDL1 protein_coding   49.77822 32.41971 65.51452 2.219103 0.7253793 1.014719 17.971527 12.689857 22.94120 1.17214866 0.6404666 0.8537573 0.3629417 0.39040000 0.3504667 -0.03993333 0.4152762505 0.0001827915 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128699 E001 0.5848434 0.0227723626 1.296497e-01 2.336610e-01 2 189770261 189770266 6 - 0.293 0.001 -9.633
ENSG00000128699 E002 1.3317097 0.0095304045 3.894093e-01 5.335060e-01 2 189770267 189770322 56 - 0.430 0.273 -0.947
ENSG00000128699 E003 0.8920389 0.0134532687 9.059130e-01 9.441740e-01 2 189770323 189770323 1 - 0.294 0.273 -0.141
ENSG00000128699 E004 113.1941179 0.0003056422 8.025100e-03 2.384459e-02 2 189770324 189770773 450 - 2.087 1.996 -0.304
ENSG00000128699 E005 128.8411871 0.0032842746 4.736311e-02 1.044747e-01 2 189770774 189771310 537 - 2.137 2.049 -0.293
ENSG00000128699 E006 96.0336885 0.0003003610 7.055375e-03 2.136916e-02 2 189771311 189771372 62 - 1.939 2.037 0.328
ENSG00000128699 E007 134.1781380 0.0017945873 1.513485e-01 2.635027e-01 2 189771373 189771430 58 - 2.104 2.154 0.170
ENSG00000128699 E008 760.9630684 0.0001061490 5.969383e-11 1.092006e-09 2 189771431 189771902 472 - 2.845 2.918 0.243
ENSG00000128699 E009 3.3237186 0.0182420157 8.745474e-02 1.712796e-01 2 189773887 189774017 131 - 0.728 0.440 -1.311
ENSG00000128699 E010 10.5975980 0.0016067827 3.542885e-02 8.247691e-02 2 189774725 189775564 840 - 1.132 0.904 -0.839
ENSG00000128699 E011 411.8202404 0.0001932567 1.041421e-01 1.968040e-01 2 189775565 189775716 152 - 2.600 2.627 0.093
ENSG00000128699 E012 346.8286638 0.0002601721 2.282107e-01 3.602850e-01 2 189782422 189782602 181 - 2.545 2.522 -0.077
ENSG00000128699 E013 33.8496957 0.0043295273 4.271258e-02 9.601741e-02 2 189782603 189783013 411 - 1.585 1.443 -0.485
ENSG00000128699 E014 96.6873993 0.0003381144 8.668249e-07 7.296280e-06 2 189783014 189783123 110 - 2.047 1.858 -0.635
ENSG00000128699 E015 46.6969447 0.0005730926 9.022111e-06 6.060820e-05 2 189783124 189783402 279 - 1.750 1.501 -0.848
ENSG00000128699 E016 27.8606551 0.0007884189 1.723657e-04 8.454152e-04 2 189783403 189783573 171 - 1.539 1.268 -0.935
ENSG00000128699 E017 30.0752318 0.0008288091 1.083341e-02 3.076627e-02 2 189783879 189784031 153 - 1.542 1.369 -0.595
ENSG00000128699 E018 9.5409057 0.0114025433 6.672844e-02 1.379580e-01 2 189784082 189784222 141 - 1.083 0.855 -0.849
ENSG00000128699 E019 6.9545030 0.0024734057 2.511573e-01 3.873214e-01 2 189784223 189784268 46 - 0.941 0.797 -0.553
ENSG00000128699 E020 99.6381358 0.0004012425 3.776774e-01 5.219875e-01 2 189784269 189784364 96 - 2.009 1.977 -0.108