ENSG00000128683

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344257 ENSG00000128683 HEK293_OSMI2_2hA HEK293_TMG_2hB GAD1 protein_coding protein_coding 7.580549 14.1473 3.892524 0.8811202 0.2107414 -1.859066 4.7507966 10.6642139 1.8730840 0.46502229 0.36798635 -2.502961 0.55545000 0.75616667 0.4745333 -0.28163333 0.0043088399 0.0001902119 FALSE TRUE
ENST00000462739 ENSG00000128683 HEK293_OSMI2_2hA HEK293_TMG_2hB GAD1 protein_coding retained_intron 7.580549 14.1473 3.892524 0.8811202 0.2107414 -1.859066 0.3097465 0.1667033 0.3942479 0.05558762 0.12436439 1.193911 0.05924583 0.01143333 0.1026667 0.09123333 0.0030523033 0.0001902119   FALSE
ENST00000488724 ENSG00000128683 HEK293_OSMI2_2hA HEK293_TMG_2hB GAD1 protein_coding retained_intron 7.580549 14.1473 3.892524 0.8811202 0.2107414 -1.859066 0.3034826 0.1637426 0.1035545 0.09479219 0.05925192 -0.613566 0.05050417 0.01243333 0.0252000 0.01276667 0.7935191559 0.0001902119 FALSE TRUE
MSTRG.19471.6 ENSG00000128683 HEK293_OSMI2_2hA HEK293_TMG_2hB GAD1 protein_coding   7.580549 14.1473 3.892524 0.8811202 0.2107414 -1.859066 0.6405976 0.7097728 0.8264304 0.06370879 0.14121148 0.216704 0.11819167 0.05036667 0.2170667 0.16670000 0.0001902119 0.0001902119 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000128683 E001 0.0000000       2 170813213 170813422 210 +      
ENSG00000128683 E002 0.0000000       2 170816114 170816256 143 +      
ENSG00000128683 E003 0.0000000       2 170816562 170816689 128 +      
ENSG00000128683 E004 0.1515154 0.0421640690 1.533142e-01   2 170816690 170816727 38 + 0.196 0.000 -10.488
ENSG00000128683 E005 3.5105115 0.0050307027 9.854658e-01 9.949241e-01 2 170816728 170816886 159 + 0.586 0.578 -0.038
ENSG00000128683 E006 5.2262644 0.0031419163 5.341306e-01 6.662460e-01 2 170816887 170816900 14 + 0.646 0.736 0.377
ENSG00000128683 E007 9.4259158 0.0018401729 4.411534e-01 5.828045e-01 2 170816901 170816911 11 + 0.862 0.953 0.344
ENSG00000128683 E008 48.0805371 0.0045174957 1.476826e-03 5.562122e-03 2 170816912 170817037 126 + 1.417 1.637 0.752
ENSG00000128683 E009 34.7539379 0.0092086895 2.831585e-02 6.863561e-02 2 170817038 170817048 11 + 1.310 1.494 0.636
ENSG00000128683 E010 0.9578146 0.0506279515 8.059326e-01 8.766487e-01 2 170817049 170817052 4 + 0.196 0.242 0.388
ENSG00000128683 E011 2.7345030 0.0056369855 2.671076e-01 4.053846e-01 2 170817255 170817416 162 + 0.646 0.456 -0.886
ENSG00000128683 E012 1.2524159 0.0117029613 2.186828e-04 1.043809e-03 2 170817769 170817769 1 + 0.699 0.074 -4.429
ENSG00000128683 E013 2.2070082 0.0077465919 2.782487e-02 6.767061e-02 2 170817770 170817898 129 + 0.699 0.325 -1.844
ENSG00000128683 E014 2.6903966 0.0062928810 5.000441e-02 1.091846e-01 2 170817899 170818528 630 + 0.746 0.426 -1.455
ENSG00000128683 E015 59.8461489 0.0132296024 3.912365e-02 8.941584e-02 2 170818529 170818610 82 + 1.568 1.721 0.522
ENSG00000128683 E016 50.3037928 0.0059106442 9.005667e-03 2.629416e-02 2 170818611 170818673 63 + 1.471 1.649 0.610
ENSG00000128683 E017 0.0000000       2 170821718 170822086 369 +      
ENSG00000128683 E018 52.5681061 0.0016389398 1.001006e-03 3.961595e-03 2 170822087 170822149 63 + 1.471 1.671 0.685
ENSG00000128683 E019 0.2214452 0.0384196890 1.000000e+00   2 170828968 170829474 507 + 0.000 0.074 9.558
ENSG00000128683 E020 66.8936136 0.0015918079 3.398422e-05 1.994303e-04 2 170829475 170829633 159 + 1.554 1.782 0.774
ENSG00000128683 E021 2.4992500 0.0067664467 8.582334e-02 1.687071e-01 2 170829634 170829872 239 + 0.196 0.533 2.078
ENSG00000128683 E022 95.5006797 0.0005053256 5.633022e-07 4.934840e-06 2 170830950 170831192 243 + 1.719 1.937 0.733
ENSG00000128683 E023 59.1640336 0.0051891115 8.229561e-02 1.631351e-01 2 170836793 170836883 91 + 1.613 1.717 0.353
ENSG00000128683 E024 51.0514124 0.0047915359 6.319248e-02 1.320235e-01 2 170842569 170842648 80 + 1.540 1.658 0.400
ENSG00000128683 E025 23.5991512 0.0089446666 2.364624e-02 5.908347e-02 2 170842649 170842654 6 + 1.132 1.353 0.777
ENSG00000128683 E026 23.8163194 0.0109547017 1.295632e-01 2.335385e-01 2 170842655 170842759 105 + 1.200 1.345 0.510
ENSG00000128683 E027 2.4336554 0.0067400545 1.704868e-07 1.656428e-06 2 170843802 170844044 243 + 0.954 0.137 -4.430
ENSG00000128683 E028 6.9161530 0.0035532524 2.074561e-05 1.282073e-04 2 170844045 170844157 113 + 1.168 0.655 -1.960
ENSG00000128683 E029 2.6068113 0.1310673746 1.875858e-02 4.880328e-02 2 170845333 170845505 173 + 0.826 0.328 -2.339
ENSG00000128683 E030 6.6269299 0.0391373823 1.127790e-05 7.403458e-05 2 170845506 170845621 116 + 1.215 0.577 -2.473
ENSG00000128683 E031 6.9623383 0.0025246652 9.795413e-07 8.140871e-06 2 170845706 170845785 80 + 1.200 0.618 -2.236
ENSG00000128683 E032 6.7568999 0.0026984703 1.287695e-06 1.044441e-05 2 170846009 170846063 55 + 1.184 0.599 -2.266
ENSG00000128683 E033 7.5048129 0.0024105632 4.129747e-09 5.460415e-08 2 170847676 170847792 117 + 1.272 0.598 -2.577
ENSG00000128683 E034 0.9974562 0.0133596194 1.898469e-01 3.135734e-01 2 170848683 170848794 112 + 0.434 0.192 -1.623
ENSG00000128683 E035 2.5099268 0.0061453290 2.645891e-04 1.235412e-03 2 170849067 170849285 219 + 0.862 0.285 -2.761
ENSG00000128683 E036 4.5069421 0.0078076872 1.700386e-04 8.352123e-04 2 170849286 170849350 65 + 1.030 0.508 -2.129
ENSG00000128683 E037 0.2955422 0.0299143405 4.180155e-01   2 170852488 170852713 226 + 0.196 0.074 -1.626
ENSG00000128683 E038 6.0944637 0.0083339750 1.883802e-04 9.140943e-04 2 170852714 170852792 79 + 1.114 0.636 -1.851
ENSG00000128683 E039 1.6597301 0.0093842657 9.147189e-02 1.774338e-01 2 170852793 170853872 1080 + 0.586 0.285 -1.623
ENSG00000128683 E040 9.5256614 0.0018400929 1.014900e-08 1.249398e-07 2 170853873 170854022 150 + 1.334 0.736 -2.209
ENSG00000128683 E041 7.5663225 0.0024866657 5.924539e-07 5.167048e-06 2 170857018 170857125 108 + 1.230 0.655 -2.183
ENSG00000128683 E042 7.1254041 0.0047046205 4.446507e-04 1.946163e-03 2 170858804 170858893 90 + 1.132 0.705 -1.624
ENSG00000128683 E043 40.6154037 0.0084356286 5.643018e-09 7.296293e-08 2 170859709 170861151 1443 + 1.813 1.414 -1.358